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Renalase in the skeletal muscle contributes to cell protective effect

Research Project

Project/Area Number 17K01839
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Applied health science
Research InstitutionUniversity of Tsukuba

Principal Investigator

TAKEKOSHI Kazuhiro  筑波大学, 医学医療系, 教授 (40261804)

Co-Investigator(Kenkyū-buntansha) 中田 由夫  筑波大学, 体育系, 准教授 (00375461)
大森 肇  筑波大学, 体育系, 教授 (20223969)
前田 清司  筑波大学, 体育系, 教授 (30282346)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2019: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Keywordsレナラーゼ / 運動 / 筋肉 / 生活習慣病 / カテコールアミン
Outline of Final Research Achievements

Renalase is a recently discovered flavin adenine dinucleotide (FAD) - dependent soluble monoamine oxidase. Its primary functions include catecholamine metabolism and blood pressure regulation. Renalase is predominantly expressed in the proximal tubule in the kidney. It is also expressed in other tissues, including the skeletal muscle, heart, and intestine.However, it remains unknown whether exercise could affect renalase expression.In this study, renalase expression in the skeletal muscle was increased by acute exercise, which was regulated by HIF-1α and NF-κB. In contrast, mRNA expression of Sp1 was unchanged in both the soleus and plantaris muscle following exercise when examining the contribution of catecholamine metabolic function in the skeletal muscle to renalase expression. In addition, renalase expression in the kidney was decreased by acute exercise.

Academic Significance and Societal Importance of the Research Achievements

運動を行った場合の血清レナラーゼが上昇することを初めて明らかにした。さらにその機序と生理的意義を解明したことで、今後運動療法の分子機序の理解につながる可能性がある。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (3 results)

All 2018 2017

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 1 results)

  • [Journal Article] Influence of acute exercise on renalase and its regulatory mechanism.2018

    • Author(s)
      Tokinoya K, Shiromoto J, Sugasawa T, Yoshida Y, Aoki K, Nakagawa Y, Ohmori H, Takekoshi K.
    • Journal Title

      Life Sci

      Volume: 210 Pages: 235-242

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Epinephrine regulates renalase expression in cultured C2C12 muscle cells.2017

    • Author(s)
      Yasuko Yoshida, Takehito Sugasawa, Katsuyuki Tokinoya, Shunji Namba, Kazuhiro
    • Journal Title

      International Journal of Analytical Bio-Science

      Volume: 5 Pages: 61-65

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Transient changes in serum renalase : The case of an amateur runner under2017

    • Author(s)
      Yasuko Yoshida, Takehito Sugasawa, Masaya Hoshino, Katsuyuki Tokinoya, Keisuke
    • Journal Title

      Journal of Physical Fitness and Sports Medicine

      Volume: 6 Pages: 159-166

    • Related Report
      2017 Research-status Report
    • Peer Reviewed

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Published: 2017-04-28   Modified: 2021-02-19  

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