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Effect of aerobic training and EPA on skeletal muscle in metabolic syndrome

Research Project

Project/Area Number 17K01842
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Applied health science
Research InstitutionNagoya University

Principal Investigator

Koike Teruhiko  名古屋大学, 総合保健体育科学センター, 教授 (90262906)

Co-Investigator(Kenkyū-buntansha) 岩間 信太郎  名古屋大学, 医学部附属病院, 病院講師 (00733536)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2017: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords老化 / インスリン抵抗性 / メタボ / サルコペニア / フレイル / メタボリック症候群 / 脂肪 / EPA / 有酸素運動 / エイコサペンタエン酸 / 骨格筋 / 高果糖食 / メタボリックシンドローム
Outline of Final Research Achievements

Sarcopenic obesity is a condition in which muscle mass loss due to aging and visceral fat accumulation coexist. We investigated whether chronic inflammation due to obesity causes a decrease in skeletal muscle synthesis and a muscle mass loss in a diet-induced obesity model and an aging-promoting model. The effect of aerobic exercise on the changes in muscle mass was also tested. Chronic inflammation and insulin resistance increase in obesity and aging, but the administration of a high-fat diet did not cause a decrease in skeletal muscle synthesis, and the combination with aerobic exercise by spinning wheel increased muscle mass. Therefore, a combination of high-fat diet and aerobic exercise may be effective in preventing sarcopenia, but such intervention should not increase ectopic fat in muscle or metabolic abnormalities.

Academic Significance and Societal Importance of the Research Achievements

人生100年時代では、超高齢期の生活の質向上が医療の目標となっており、筋力低下に代表されるフレイルな状態の予防対策が求められている。若~中年期では、肥満による代謝異常予防のため、動物性脂肪とカロリー摂取制限が有効だが、老年期以降では、フレイルの予防に視点をシフトした食事と運動が必要となる。動物性脂肪摂取は、代謝異常を引き起こすが、サルコペニア予防からは、有効な可能性もある。有酸素運動は、レジスタンス運動とは異なり筋量増加に対する効果は小さいが、高脂肪食による代謝異常を予防し、かつ高脂肪食との併用で骨格筋を増加させる(あるいは維持する)効果が期待できる可能性がある。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (24 results)

All 2020 2019 2018 2017

All Journal Article (13 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 12 results,  Open Access: 9 results) Presentation (11 results) (of which Int'l Joint Research: 3 results)

  • [Journal Article] Muscle deoxygenation and neuromuscular activation in synergistic muscles during intermittent exercise under hypoxic conditions2020

    • Author(s)
      Akito Yoshiko, Keisho Katayama, Koji Ishida, Ryosuke Ando, Teruhiko Koike, Yoshiharu Oshida, Hiroshi Akima
    • Journal Title

      Scientific Reports

      Volume: 10 Issue: 1 Pages: 295-295

    • DOI

      10.1038/s41598-019-57099-y

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Comparing intramuscular adipose tissue on T1-weighted and two-point Dixon images.2020

    • Author(s)
      M. Ogawa, A. Yoshiko, N. Tanaka, T. Koike, Y. Oshida, H. Akima.
    • Journal Title

      PLoS ONE

      Volume: 15(4) Issue: 4 Pages: 0231156-0231156

    • DOI

      10.1371/journal.pone.0231156

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Age-related changes in muscle volume and intramuscular fat content in quadriceps femoris and hamstrings2020

    • Author(s)
      Maya Hioki, Nana Kanehira, Teruhiko Koike, Akira Saito, Kiyoshi Shimaoka, Hisataka Sakakibara, Yoshiharu Oshida, Hiroshi Akima
    • Journal Title

      Experimental Gerontology

      Volume: - Pages: 110834-110834

    • DOI

      10.1016/j.exger.2020.110834

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Higher and Lower Muscle Echo Intensity in Elderly Individuals Is Distinguished by Muscle Size, Physical Performance and Daily Physical Activity2019

    • Author(s)
      Yoshiko Akito、Natsume Yukie、Makino Taeko、Hayashi Takahiro、Umegaki Hiroyuki、Yoshida Yasuko、Cheng Xian Wu、Kuzuya Masafumi、Ishida Koji、Koike Teruhiko、Oshida Yoshiharu、Akima Hiroshi
    • Journal Title

      Ultrasound in Medicine & Biology

      Volume: 45 Issue: 9 Pages: 2372-2380

    • DOI

      10.1016/j.ultrasmedbio.2019.05.029

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Twenty-four months’ resistance and endurance training improves muscle size and physical functions but not muscle quality in older adults requiring long-term care.2019

    • Author(s)
      A. Yoshiko, T. Kaji, H. Sugiyama, T. Koike, Y. Oshida, H. Akima.
    • Journal Title

      J Nutr Health Aging

      Volume: 23(6) Issue: 6 Pages: 564-570

    • DOI

      10.1007/s12603-019-1208-8

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Muscle quality characteristics of muscles in the thigh, upper arm and lower back in elderly men and women2018

    • Author(s)
      Yoshiko Akito、Kaji Takashi、Sugiyama Hiroki、Koike Teruhiko、Oshida Yoshiharu、Akima Hiroshi
    • Journal Title

      European Journal of Applied Physiology

      Volume: 118 Issue: 7 Pages: 1385-1395

    • DOI

      10.1007/s00421-018-3870-7

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effect of prior chronic aerobic exercise on overload-induced skeletal muscle hypertrophy in mice.2018

    • Author(s)
      Siriguleng, Koike Teruhiko, Natsume Yukie, Iwama Shintaro, Oshida Yoshiharu
    • Journal Title

      Physiological Research

      Volume: 67(5) Pages: 765-775

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effects of post-fracture non-weight-bearing immobilization on muscle atrophy, intramuscular and intermuscular adipose tissues in the thigh and calf2018

    • Author(s)
      Yoshiko Akito、Yamauchi Koun、Kato Takayuki、Ishida Koji、Koike Teruhiko、Oshida Yoshiharu、Akima Hiroshi
    • Journal Title

      Skeletal Radiology

      Volume: 47 Issue: 11 Pages: 1541-1549

    • DOI

      10.1007/s00256-018-2985-6

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Relationship between physical activity and intramyocellular lipid content is different between young and older adults2018

    • Author(s)
      Hioki Maya、Kanehira Nana、Koike Teruhiko、Saito Akira、Takahashi Hideyuki、Shimaoka Kiyoshi、Sakakibara Hisataka、Oshida Yoshiharu、Akima Hiroshi
    • Journal Title

      European Journal of Applied Physiology

      Volume: 119 Issue: 1 Pages: 113-122

    • DOI

      10.1007/s00421-018-4005-x

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of 10-week walking and walking with home-based resistance training on muscle quality, muscle size, and physical functional tests in healthy older individuals2018

    • Author(s)
      Yoshiko Akito、Tomita Aya、Ando Ryosuke、Ogawa Madoka、Kondo Shohei、Saito Akira、Tanaka Noriko I.、Koike Teruhiko、Oshida Yoshiharu、Akima Hiroshi
    • Journal Title

      European Review of Aging and Physical Activity

      Volume: 15 Issue: 1 Pages: 13-13

    • DOI

      10.1186/s11556-018-0201-2

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Elevated sympathetic vasomotor outflow in response to increased inspiratory muscle activity during exercise is less in young women compared with men.2017

    • Author(s)
      K. Katayama, JR. Smith, K. Goto, K. Shimizu, M Saito, K. Ishida, T. Koike, S. Iwase, CA. Harms.
    • Journal Title

      Experimental Physiology

      Volume: 103 Issue: 4 Pages: 570-580

    • DOI

      10.1113/ep086817

    • Related Report
      2018 Research-status Report 2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Three-dimensional comparison of intramuscular fat content between young and old adults.2017

    • Author(s)
      A. Yoshiko, M. Hioki, N. Kanehira, K. Shimaoka, T. Koike, H. Sakakibara, Y. Oshida. H. Akima.
    • Journal Title

      BMC Medical Imaging

      Volume: 17 Issue: 1 Pages: 1-8

    • DOI

      10.1186/s12880-017-0185-9

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effect of 12-month resistance and endurance training on quality, quantity, and function of skeletal muscle in older adults requiring long-term care.2017

    • Author(s)
      A. Yoshiko, T. Kaji, H. Sugiyama, T. Koike, Y. Oshida, H. Akima.
    • Journal Title

      Experimental Gerontology

      Volume: 98 Pages: 230-237

    • Related Report
      2017 Research-status Report
  • [Presentation] 希少糖D-プシコースは高ショ糖食誘発インスリン抵抗性を改善する-インスリン正 常血糖クランプ法を用いて2019

    • Author(s)
      夏目有紀枝、山田貴子、飯田哲郎、尾崎信暁、楠正隆、押田芳治、小池晃彦
    • Organizer
      第62回日本糖尿病学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 標準BMIの高齢者における内臓脂肪および体組成、体力に対する運動介入の効果2019

    • Author(s)
      夏目有紀枝、小池晃彦、吉子彰人、石田浩司、秋間広、片山敬章、牧野多恵子、林尊弘、成憲武、梅垣宏行、吉田安子、葛谷雅文、押田芳治
    • Organizer
      第73回日本体力医学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 身体活動量と大腿部筋組織および筋内脂肪との関係に年齢が関係する2019

    • Author(s)
      小川まどか、田中憲子、吉子彰人、押田芳治、小池晃彦、秋間広
    • Organizer
      第73回日本体力医学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Effects of 12 months resistance and endurance training on muscle quantity, quality and physical functions in elderly requiring long-term care2018

    • Author(s)
      A. Yoshiko, T. Kaji, H. Sugiyama, T. Koike, Y. Oshida, H. Akima
    • Organizer
      International Conference of Frailty and Sarcopenia Research
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Effects of 24 months resistance and endurance training on muscle quality, quantity and physical functions in elderly with long-term care2018

    • Author(s)
      A. Yoshiko, T. Kaji, H. Sugiyama, T. Koike, Y. Oshida, H. Akima
    • Organizer
      The 65th ACSM Annual Meeting of American College of Sports Medicine
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Blunted sympathetic vasomotor outflow to inspiratory resistive breathing during exercise in women compared to men2018

    • Author(s)
      K. Katayama, JR. Smith, K. Goto, K. Shimizu, M. Saito, K. Ishida, T. Koike, S. Iwase, CA. Harms
    • Organizer
      The 65th ACSM Annual Meeting of American College of Sports Medicine
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] 高齢2型糖尿病患者における骨粗鬆症治療薬イバンドロン酸の効果と生活習慣の関係2018

    • Author(s)
      夏目有紀枝、楠正隆、小池晃彦、押田芳治
    • Organizer
      第61回日本糖尿病学会大会
    • Related Report
      2018 Research-status Report
  • [Presentation] 高齢者における筋の質的指標と身体機能、体組成および身体活動量の関係2018

    • Author(s)
      吉子彰人、夏目有紀枝、梅垣宏行、吉田安子、牧野多恵子、林尊弘、石田浩司、小池晃彦、押田芳治、葛谷雅文、秋間広
    • Organizer
      第73回日本体力医学会大会
    • Related Report
      2018 Research-status Report
  • [Presentation] 中高齢者男女における筋電気刺激法による外側広筋のIMCLの早期変化2018

    • Author(s)
      日置麻也、兼平奈奈、小池晃彦、斎藤輝、高橋英幸、島岡清、榊原久孝、押田芳治、秋間広
    • Organizer
      第73回日本体力医学会大会
    • Related Report
      2018 Research-status Report
  • [Presentation] 高齢者に対する在宅での運動プログラムが骨格筋内脂肪指標、筋量および身体機能に 及ぼす影響2017

    • Author(s)
      吉子彰人、富田彩、安藤良介、小川まどか、近藤翔平、斉藤輝、田中憲子、小池晃彦、押田芳治、秋間広
    • Organizer
      第60回日本糖尿病学会大会
    • Related Report
      2017 Research-status Report
  • [Presentation] 高齢者における筋肉脂肪と身体活動量・活動強度との関係2017

    • Author(s)
      吉子彰人、夏目有紀枝、梅垣宏行、吉田安子、牧野多恵子、林尊弘、成憲武、石田浩司、片山敬章、小池晃彦、葛谷雅文、押田芳治、秋間広
    • Organizer
      第72回日本体力医学会大会
    • Related Report
      2017 Research-status Report

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Published: 2017-04-28   Modified: 2021-02-19  

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