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Regulatory mechanism of appetite and obesity by GDE7, a novel Ca-dependent lipid-metabolizing enzyme

Research Project

Project/Area Number 17K01852
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Applied health science
Research InstitutionKawasaki Medical School

Principal Investigator

Tsuboi Kazuhito  川崎医科大学, 医学部, 講師 (80346642)

Co-Investigator(Kenkyū-buntansha) 宇山 徹  香川大学, 医学部, 助教 (30457337)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords小腸 / 肥満 / 脂質代謝 / リン脂質 / 小胞体 / 酵素 / 脂質メディエーター / 加水分解酵素 / 食欲 / リゾホスホリパーゼD / 代謝 / 脂質 / 生活習慣病
Outline of Final Research Achievements

N-Acylethanolamines are anti-obesity lipids biosynthesized in small intestine, which show bioactivities including appetite suppression and lipolysis. In the present study, we suggested 1) that the reaction pathway(s) involving glycerophosphodiesterase 7 (GDE7) and other enzymes are important in small intestine, 2) that the enzyme supplying the precursor lipid to this reaction pathway(s) is positively regulated, and 3) that GDE7 is constitutively activated by calcium ions in the endoplasmic reticulum.

Academic Significance and Societal Importance of the Research Achievements

本研究の学術的意義として、いまだ解明の進んでいないN-アシルエタノールアミンの哺乳類体内における生成機構において、GDE7などの酵素が関与する経路の小腸における重要性を示したとともに、本機構の活性化メカニズムを提示したことが挙げられる。社会的意義として、生体内に備わっている抗肥満作用の機構解明に貢献することや、関連酵素の活性を制御する薬物やN-アシルエタノールアミンの関連化合物の新規抗肥満薬としての応用に繋がることが挙げられる。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (54 results)

All 2020 2019 2018 2017 Other

All Journal Article (10 results) (of which Peer Reviewed: 10 results,  Open Access: 3 results) Presentation (41 results) (of which Int'l Joint Research: 9 results,  Invited: 1 results) Book (1 results) Remarks (2 results)

  • [Journal Article] Chronic Treatment with α-Lipoic Acid Improves Endothelium-Dependent Vasorelaxation of Aortas in High-Fat Diet-Fed Mice2019

    • Author(s)
      Takenouchi Y, Tsuboi K, Ohsuka K, Nobe K, Ohtake K, Okamoto Y, Kasono K
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 42 Issue: 9 Pages: 1456-1463

    • DOI

      10.1248/bpb.b18-00800

    • NAID

      130007700165

    • ISSN
      0918-6158, 1347-5215
    • Year and Date
      2019-09-01
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Intracellular Ca2+-dependent formation of N-acyl-phosphatidylethanolamines by human cytosolic phospholipase A2ε2019

    • Author(s)
      Binte Mustafiz Smriti Sultana、Uyama Toru、Morito Katsuya、Takahashi Naoko、Kawai Katsuhisa、Hussain Zahir、Tsuboi Kazuhito、Araki Nobukazu、Yamamoto Kei、Tanaka Tamotsu、Ueda Natsuo
    • Journal Title

      Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids

      Volume: 1864 Issue: 12 Pages: 158515-158515

    • DOI

      10.1016/j.bbalip.2019.158515

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Phosphatidylserine-stimulated production of N -acyl-phosphatidylethanolamines by Ca 2+ -dependent N -acyltransferase2018

    • Author(s)
      Hussain Zahir、Uyama Toru、Kawai Katsuhisa、Binte Mustafiz Smriti Sultana、Tsuboi Kazuhito、Araki Nobukazu、Ueda Natsuo
    • Journal Title

      Biochim Biophys Acta-Mol Cell Biol Lipids

      Volume: 1863 Issue: 5 Pages: 493-502

    • DOI

      10.1016/j.bbalip.2018.02.002

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Endocannabinoids and related N-acylethanolamines: biological activities and metabolism2018

    • Author(s)
      Tsuboi Kazuhito、Uyama Toru、Okamoto Yasuo、Ueda Natsuo
    • Journal Title

      Inflammation and Regeneration

      Volume: 38 Issue: 1 Pages: 28-28

    • DOI

      10.1186/s41232-018-0086-5

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The role of intracellular anionic phospholipids in the production of N-acyl-phosphatidylethanolamines by cytosolic phospholipase A2epsilon2018

    • Author(s)
      Binte Mustafiz Smriti Sultana、Uyama Toru、Hussain Zahir、Kawai Katsuhisa、Tsuboi Kazuhito、Araki Nobukazu、Ueda Natsuo
    • Journal Title

      The Journal of Biochemistry

      Volume: 165 Issue: 4 Pages: 343-352

    • DOI

      10.1093/jb/mvy104

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] The Biosynthetic Pathways of N-Acylethanolamines in Mammals2018

    • Author(s)
      Binte Mustafiz Smriti Sultana、Uyama Toru、Hussain Zahir、Tsuboi Kazuhito、Ueda Natsuo
    • Journal Title

      eLS

      Volume: なし Pages: 1-11

    • DOI

      10.1002/9780470015902.a0027711

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Peripheral tissue levels and molecular species compositions of N-acyl-phosphatidylethanolamine and its metabolites in mice lacking N-acyl-phosphatidylethanolamine-specific phospholipase D2017

    • Author(s)
      Inoue Manami、Tsuboi Kazuhito、Okamoto Yoko、Hidaka Mayumi、Uyama Toru、Tsutsumi Toshihiko、Tanaka Tamotsu、Ueda Natsuo、Tokumura Akira
    • Journal Title

      J Biochem

      Volume: 162 Issue: 6 Pages: 449-458

    • DOI

      10.1093/jb/mvx054

    • NAID

      40021421359

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] An involvement of phospholipase A/acyltransferase family proteins in peroxisome regulation and plasmalogen metabolism2017

    • Author(s)
      Uyama Toru、Tsuboi Kazuhito、Ueda Natsuo
    • Journal Title

      FEBS Lett

      Volume: 591 Issue: 18 Pages: 2745-2760

    • DOI

      10.1002/1873-3468.12787

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Mammalian enzymes responsible for the biosynthesis of N -acylethanolamines2017

    • Author(s)
      Hussain Zahir、Uyama Toru、Tsuboi Kazuhito、Ueda Natsuo
    • Journal Title

      Biochim Biophys Acta-Mol Cell Biol Lipids

      Volume: 1862 Issue: 12 Pages: 1546-1561

    • DOI

      10.1016/j.bbalip.2017.08.006

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] グリセロホスホジエステラーゼ・ファミリーによるN-アシルエタノールアミンおよびリゾホスファチジン酸の生成2017

    • Author(s)
      坪井一人、宇山 徹、上田夏生
    • Journal Title

      ビタミン

      Volume: 91 Pages: 489-496

    • NAID

      130007472636

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Presentation] 抗炎症・食欲抑制作用を有する脂質メディエーターであるN-アシルエタノールアミンの分解における酸性セラミダーゼの役割2020

    • Author(s)
      坪井一人, 田井達也, 山下量平, 宇山徹, 岡本蓉子, 郷慎司, 渡邉悦子, ラフマンイッファットアラソニア, 芳地一, 田中保, 岡本安雄, 徳村彰, 松田純子, 上田夏生
    • Organizer
      第93回日本薬理学会年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] マウス虚血後再灌流腎間質線維化におけるリゾホスファチジン酸受容体の遺伝子発現変化2020

    • Author(s)
      竹之内康広, 北風圭介, 坪井一人, 岡本安雄
    • Organizer
      第93回日本薬理学会年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 酸性セラミダーゼは抗炎症・食欲抑制性メディエーターであるN-アシルエタノールアミンを生体内で加水分解する2020

    • Author(s)
      坪井一人, 田井達也, 山下量平, 宇山徹, 岡本蓉子, 郷慎司, 渡邉悦子, Rahman Iffat Ara Sonia, 芳地一, 田中保, 岡本安雄, 徳村彰, 松田純子, 上田夏生
    • Organizer
      日本薬学会第140年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] N-アシルエタノールアミンを生合成するホスホリパーゼD型酵素の欠損マウスを用いた末梢臓器におけるN-アシルエタノールアミンの生成機構の解析2019

    • Author(s)
      坪井一人, 井上愛美, 岡本蓉子, 日高麻由美, 宇山徹, 堤敏彦, 田中保, 岡本安雄, 上田夏生, 徳村彰
    • Organizer
      第92回日本薬理学会年会
    • Related Report
      2019 Annual Research Report 2018 Research-status Report
  • [Presentation] 肺線維症におけるgrowth/differentiation factor 15 (GDF15)の役割2019

    • Author(s)
      竹之内康広, 坪井一人, 岡本安雄
    • Organizer
      第92回日本薬理学会年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] N-アシルエタノールアミンの生成に関わるホスホリパーゼD型酵素の欠損マウスを用いたN-アシルエタノールアミンの生合成機構の解析2019

    • Author(s)
      坪井一人, 井上愛美, 岡本蓉子, 日高麻由美, 宇山徹, 堤敏彦, 田中保, 岡本安雄, 上田夏生, 徳村彰
    • Organizer
      日本薬学会第139年会
    • Related Report
      2019 Annual Research Report 2018 Research-status Report
  • [Presentation] Growth/differentiation factor 15 (GDF15)が肺線維化へ及ぼす影響2019

    • Author(s)
      竹之内康広, 坪井一人, 岡本安雄
    • Organizer
      日本薬学会第139年会
    • Related Report
      2019 Annual Research Report 2018 Research-status Report
  • [Presentation] 肺線維症で増加するgrowth/differentiation factor 15 (GDF15) が線維化へ及ぼす影響2019

    • Author(s)
      竹之内康広, 坪井一人, 北風圭介, 岡本安雄
    • Organizer
      第60回日本生化学会中国・四国支部例会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Endogenous anionic phospholipid-assisted production of N-acyl-phosphatidylethanolamines by cytosolic phospholipase A2_2019

    • Author(s)
      Hussain Zahir, Uyama Toru, Binte Mustafiz Smriti Sultana, Kawai Katsuhisa, Tsuboi Kazuhito, Araki Nobukazu, Ueda Natsuo
    • Organizer
      第60回日本生化学会中国・四国支部例会
    • Related Report
      2019 Annual Research Report
  • [Presentation] N-アシルエタノールアミンの生成に関わるcPLA2εの酸性リン脂質による制御2019

    • Author(s)
      宇山徹, Binte Mustafiz Smriti Sultana, Hussain Zahir, 川合克久, 坪井一人, 荒木伸一, 上田夏生
    • Organizer
      日本ビタミン学会第71回大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Multiple pathways for N-acylethanolamine biosynthesis from N-acylphosphatidylethanolamine: tissue-dependent contribution of each pathway2019

    • Author(s)
      Tsuboi Kazuhito, Inoue Manami, Okamoto Yoko, Hidaka Mayumi, Uyama Toru, Tsutsumi Toshihiko, Tanaka Tamotsu, Okamoto Yasuo, Ueda Natsuo, Tokumura Akira
    • Organizer
      60th International Conference on the Bioscience of Lipids
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Anionic phospholipids facilitate the formation of N-acyl-phosphatidylethanolamines by cytosolic phospholipase A2ε2019

    • Author(s)
      Uyama Toru, Hussain Zahir, Binte Mustafiz Smriti Sultana, Kawai Katsuhisa, Tsuboi Kazuhito, Araki Nobukazu, Ueda Natsuo
    • Organizer
      60th International Conference on the Bioscience of Lipids
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Expression of lysophosphatidic acid receptor subtypes in ischemia/reperfusion-induced renal fibrosis in mice2019

    • Author(s)
      Takenouchi Yasuhiro, Tsuboi Kazuhito, Kitakaze Keisuke, Nakagawa Yasuhito, Araki Keigo, Yamamoto Suguru, Kawai Yuji, Niiyama Daichi, Okamoto Yasuo
    • Organizer
      60th International Conference on the Bioscience of Lipids
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 虚血後再灌流腎間質線維化モデルにおける脂質メディエーターリゾホスファチジン酸受容体の遺伝子発現変化2019

    • Author(s)
      中川靖仁, 山本優, 荒木啓吾, 竹之内康広, 北風圭介, 坪井一人, 岡本安雄
    • Organizer
      第135回日本薬理学会近畿部会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Anionic phospholipids enhance the production of N-acyl-phosphatidylethanolamines by cytosolic phospholipase A2ε2019

    • Author(s)
      Uyama Toru, Hussain Zahir, Binte Mustafiz Smriti Sultana, Kawai Katsuhisa, Tsuboi Kazuhito, Araki Nobukazu, Ueda Natsuo
    • Organizer
      Gordon research conference (Cannabinoid Function in the CNS)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Anionic phospholipids stimulate the Ca2+-dependent formation of N-acyl-phosphatidylethanolamines by cytosolic phospholipase A2ε2019

    • Author(s)
      Hussain Zahir, Uyama Toru, Binte Mustafiz Smriti Sultana, Kawai Katsuhisa, Tsuboi Kazuhito, Araki Nobukazu, Ueda Natsuo
    • Organizer
      第92回日本生化学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 虚血後再灌流腎間質線維化モデルマウスにおけるリゾホスファチジン酸の受容体および代謝酵素の遺伝子発現解析2019

    • Author(s)
      竹之内康広, 中川靖人, 山本優, 荒木啓吾, 北風圭介, 坪井一人, 岡本安雄
    • Organizer
      第92回日本生化学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] cPLA2εによるN-アシル-ホスファチジルエタノールアミンの細胞内カルシウム依存的な生成2019

    • Author(s)
      宇山徹, Binte Mustafiz Smriti Sultana, 森戸克弥, 高橋尚子, 川合克久, Hussain Zahir, 坪井一人, 荒木伸一, 山本圭, 田中保, 上田夏生
    • Organizer
      第92回日本生化学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 抗炎症・食欲抑制性メディエーターであるN-アシルエタノールアミンの酸性セラミダーゼによる加水分解2019

    • Author(s)
      坪井一人, 田井達也, 山下量平, 宇山徹, 岡本蓉子, 郷 慎司, 渡邉悦子, Rahman Iffat Ara Sonia, 芳地一, 田中保, 岡本安雄, 徳村彰, 松田純子, 上田夏生
    • Organizer
      第32回創薬・薬理フォーラム岡山
    • Related Report
      2019 Annual Research Report
  • [Presentation] 肺線維症における growth/differentiation factor 15 (GDF15) の役割2019

    • Author(s)
      竹之内康広, 坪井一人, 岡本安雄
    • Organizer
      第92回日本薬理学会年会
    • Related Report
      2018 Research-status Report
  • [Presentation] Studies with purified cytosolic phospholipase A2epsilon reveal the stimulatory effect of phosphatidylserine on its Ca(2+)-dependent N-acyltransferase activity2018

    • Author(s)
      Hussain Zahir, Uyama Toru, Kawai Katsuhisa, Binte Mustafiz Smriti Sultana, Tsuboi Kazuhito, Araki Nobukazu, Ueda Natsuo
    • Organizer
      第59回日本生化学会中国・四国支部例会
    • Related Report
      2018 Research-status Report
  • [Presentation] Enhancement of cytosolic phospholipase A2epsilon-catalyzed formation of N-acyl-phosphatidylethanolamine by phosphatidylserine2018

    • Author(s)
      Hussain Zahir, Uyama Toru, Kawai Katsuhisa, Binte Mustafiz Smriti Sultana, Tsuboi Kazuhito, Araki Nobukazu, Ueda Natsuo
    • Organizer
      第60回日本脂質生化学会
    • Related Report
      2018 Research-status Report
  • [Presentation] ホスファチジルセリンによるN-アシルエタノールアミン生合成の制御2018

    • Author(s)
      宇山徹, Hussain Zahir, 川合克久, Binte Mustafiz Smriti Sultana, 坪井一人, 荒木伸一, 上田夏生
    • Organizer
      日本ビタミン学会第70回大会
    • Related Report
      2018 Research-status Report
  • [Presentation] Gender difference of vascular functional changes in diabetic condition2018

    • Author(s)
      Takenouchi Yasuhiro, Tsuboi Kazuhito, Ohtake Kazuo, Kasono Keizo, Okamoto Yasuo
    • Organizer
      18th World Congress of Basic and Clinical Pharmacology
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Characterization of cytosolic phospholipase A2epsilon: phosphatidylserine-stimulated production of N-acyl-phosphatidylethanolamine2018

    • Author(s)
      Hussain Zahir, Uyama Toru, Kawai Katsuhisa, Binte Mustafiz Smriti Sultana, Tsuboi Kazuhito, Araki Nobukazu, Ueda Natsuo
    • Organizer
      28th Annual Symposium of the International Cannabinoid Research Society
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Biosynthesis of N-acylethanolamine and lysophosphatidic acid by glycerophosphodiesterase GDE4 and GDE72018

    • Author(s)
      Tsuboi Kazuhito, Rahman Iffat Ara Sonia, Hussain Zahir, Yamashita Ryouhei, Uyama Toru, Takenouchi Yasuhiro, Tanaka Tamotsu, Okamoto Yasuo, Tokumura Akira, Ueda Natsuo
    • Organizer
      18th World Congress of Basic and Clinical Pharmacology
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Microarray analysis in bleomycin-induced lung fibrosis.2018

    • Author(s)
      Okamoto Yasuo, Komi Masahiro, Takenouchi Yasuhiro, Tsuboi Kazuhito
    • Organizer
      18th World Congress of Basic and Clinical Pharmacology
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] 抗がん薬ブレオマイシンによる肺線維芽細胞の細胞老化におけるスフィンゴシン1-リン酸2型受容体の抑制効果2018

    • Author(s)
      岡本安雄, 趙娟娟, 竹之内康広, 坪井一人, 多久和陽
    • Organizer
      第29回創薬・薬理フォーラム岡山
    • Related Report
      2018 Research-status Report
  • [Presentation] 肺線維症の発症や進展を左右する分子の探索2018

    • Author(s)
      竹之内康広, 坪井一人, 岡本安雄
    • Organizer
      第29回創薬・薬理フォーラム岡山
    • Related Report
      2018 Research-status Report
  • [Presentation] Analysis of purified cytosolic phospholipase A2epsilon reveals the stimulatory effect of phosphatidylserine2018

    • Author(s)
      Hussain Zahir, Uyama Toru, Kawai Katsuhisa, Smriti Sultana Binte Mustafiz, Tsuboi Kazuhito, Araki Nobukazu, Ueda Natsuo
    • Organizer
      第91回日本生化学会大会
    • Related Report
      2018 Research-status Report
  • [Presentation] N-アシル-ホスファチジルエタノールアミン特異的ホスホリパーゼD欠損マウスの末梢臓器における関連脂質とその代謝経路の解析2018

    • Author(s)
      坪井一人, 井上愛美, 岡本蓉子, 日高麻由美, 宇山徹, 堤敏彦, 田中保, 岡本安雄, 上田夏生, 徳村彰
    • Organizer
      第91回日本生化学会大会
    • Related Report
      2018 Research-status Report
  • [Presentation] 虚血後再灌流腎間質線維化モデルにおける脂質メディエーターの代謝酵素・受容体の遺伝子発現変化2018

    • Author(s)
      竹之内康広, 山本優, 荒木啓吾, 河合勇治, 新山大地, 坪井一人, 岡本安雄
    • Organizer
      第30回創薬・薬理フォーラム岡山
    • Related Report
      2018 Research-status Report
  • [Presentation] cDNA cloning and characterization of calcium independent phospholipase A/acyltransferase-1 long isoform that produces N-acylphosphatidylethanolamines (NAPEs)2017

    • Author(s)
      Zahir Hussain, Toru Uyama, Katsuhisa Kawai, Iffat Ara Sonia Rahman, Kazuhito Tsuboi, Nobukazu Araki, Natsuo Ueda
    • Organizer
      第58回日本生化学会中国・四国支部例会
    • Related Report
      2017 Research-status Report
  • [Presentation] 前立腺癌細胞株における抗炎症脂質分解酵素N-アシルエタノールアミン水解酸性アミダーゼ(NAAA)のsplice variantの発現解析2017

    • Author(s)
      佐倉雄馬、坪井一人、宇山 徹、張 霞、筧 善行、上田夏生
    • Organizer
      第58回日本生化学会中国・四国支部例会
    • Related Report
      2017 Research-status Report
  • [Presentation] LRATファミリーに属するPLAAT-1の2つのアイソフォームの比較機能解析2017

    • Author(s)
      宇山 徹、Zahir Hussain、川合克久、Iffat Ara Sonia Rahman、坪井一人、荒木伸一、上田夏生
    • Organizer
      日本ビタミン学会第69回大会
    • Related Report
      2017 Research-status Report
  • [Presentation] Calcium independent generation of N-acylphosphatidylethanolamines (NAPEs) by phospholipase A/acyltransferase-1 isoforms in humans and mice2017

    • Author(s)
      Zahir Hussain, Toru Uyama, Katsuhisa Kawai, Iffat Ara Sonia Rahman, Kazuhito Tsuboi, Nobukazu Araki, Natsuo Ueda
    • Organizer
      第58回日本脂質生化学会
    • Related Report
      2017 Research-status Report
  • [Presentation] Characterizaton of isoforms of the calcium-independent N-acyltransferase PLAAT-1 in humans and mice2017

    • Author(s)
      Toru Uyama, Zahir Hussain, Katsuhisa Kawai, Iffat Ara Sonia Rahman, Kazuhito Tsuboi, Nobukazu Araki, Natsuo Ueda
    • Organizer
      27th Annual Symposium of the International Cannabinoid Research Society
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 抗炎症脂質パルミトイルエタノールアミドを加水分解するリソソーム酵素NAAAの前立腺癌細胞株におけるスプライスバリアントの発現解析2017

    • Author(s)
      上田夏生、佐倉雄馬、坪井一人、宇山 徹、筧 善行
    • Organizer
      第38回日本炎症・再生医学会
    • Related Report
      2017 Research-status Report
  • [Presentation] エイコサペンタエン酸による糖尿病性血管内皮機能障害に対する慢性投与の治療効果および血管への直接作用2017

    • Author(s)
      竹之内康広、坪井一人、大竹一男、加園恵三、岡本安雄
    • Organizer
      第132回日本薬理学会近畿部会
    • Related Report
      2017 Research-status Report
  • [Presentation] 脂溶性バイオファクターであるN-アシルエタノールアミンの生合成機構2017

    • Author(s)
      宇山 徹、坪井一人、上田夏生
    • Organizer
      2017年度生命科学系学会合同年次大会(第40回日本分子生物学会年会・第90回日本生化学会大会)
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] 脂質メディエーターであるN-アシルエタノールアミンとリゾホスファチジン酸の新規生合成機構2017

    • Author(s)
      坪井一人、Iffat Ara Sonia Rahman、Zahir Hussain、山下量平、岡本蓉子、宇山 徹、竹之内康広、田中 保、岡本安雄、徳村 彰、上田夏生
    • Organizer
      第28回創薬・薬理フォーラム岡山
    • Related Report
      2017 Research-status Report
  • [Book] Inhibition of NAPE-PLD activity by natural compounds and synthetic drugs, and its biological relevance. In New tools to interrogate endocannabinoid signalling-from natural compounds to synthetic drugs2020

    • Author(s)
      Tsuboi Kazuhito、Uyama Toru、Ueda Natsuo
    • Publisher
      Royal Society of Chemistry
    • ISBN
      9781788018012
    • Related Report
      2019 Annual Research Report
  • [Remarks] 川崎医科大学 教室紹介 薬理学教室

    • URL

      https://m.kawasaki-m.ac.jp/classroom/course.php?id=205

    • Related Report
      2019 Annual Research Report 2018 Research-status Report
  • [Remarks] 川崎医科大学 教室紹介 薬理学教室

    • URL

      https://www.kawasaki-m.ac.jp/med/study/info.php?id=205

    • Related Report
      2017 Research-status Report

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Published: 2017-04-28   Modified: 2021-02-19  

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