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Establishment of methodology for controlling postprandial blood sugar to regulate free-water in intestinal contents for clinical application

Research Project

Project/Area Number 17K01863
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Applied health science
Research InstitutionKoriyama Women's University (2018-2019)
Fukuoka Women's University (2017)

Principal Investigator

Takahashi Toru  郡山女子大学, 家政学部, 准教授 (80324292)

Co-Investigator(Kenkyū-buntansha) 久保 金弥  名古屋女子大学, 健康科学部, 教授 (00329492)
安細 敏弘  九州歯科大学, 歯学部, 教授 (80244789)
小野塚 実  神奈川歯科大学, 歯学部, 名誉教授 (90084780)
徳永 美希  神奈川県立保健福祉大学, 保健福祉学部, 助教 (90610238)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords自由水 / 水の拡散係数 / グルコースの拡散係数 / 消化管内容物 / 食後血糖 / 吸収速度 / 消化管内容物の移動 / 咀嚼物 / 粘度 / 飯 / 糖の拡散係数 / ベイジアンネットワーク / 唾液 / 小腸 / 物性
Outline of Final Research Achievements

Number of persons with Diabetes mellitus were more than 3 million in Japan. High glucose levels in blood increase risk of cancer and evoke cognitive impairment. Thus, controlling glucose levels in blood would be a significant for people in Japan. Glucose levels in blood depends on absorption rate of glucose in the small intestine. The present study revealed a key factor to control absorption rate of glucose. The study suggests that the key factor to control absorption rate of glucose was free water levels in digesta in the small intestine.

Academic Significance and Societal Importance of the Research Achievements

The present study suggests that the key factor to control absorption rate of glucose was free water levels in digesta in the small intestine. If free water levels in digesta in the small intestine can be controlled, we can regulate glucose levels in blood.

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (32 results)

All 2020 2019 2018 2017 Other

All Int'l Joint Research (7 results) Journal Article (8 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 8 results,  Open Access: 3 results) Presentation (11 results) (of which Int'l Joint Research: 5 results,  Invited: 4 results) Book (6 results)

  • [Int'l Joint Research] Swansea University(英国)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] University of Ottawa(カナダ)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] Halberg Hospital and Research Institute(インド)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] Douglas W. Wilson/Durham University,(英国)

    • Related Report
      2018 Research-status Report
  • [Int'l Joint Research] Ram B. Singh/Halberg Hospital and Research Institute(インド)

    • Related Report
      2018 Research-status Report
  • [Int'l Joint Research] School of Medicine,/Pharmacy and Health, Durham University/UK(Douglas W. Wilson)

    • Related Report
      2017 Research-status Report
  • [Int'l Joint Research] Halberg Hospital and Research Institute,/India(Ram B. Singh)

    • Related Report
      2017 Research-status Report
  • [Journal Article] Faster short-chain fatty acids absorption from the cecum following polydextrose ingestion increases the salivary immunoglobulin A flow rate in rats2020

    • Author(s)
      Yuko Yamamoto 1 †, Toshiya Morozumi 2 †, Toru Takahashi 3 , Juri Saruta, Masahiro To, Wakako Sakaguchi, Tomoko Shimizu, Nobuhisa Kubota and Keiichi Tsukinoki
    • Journal Title

      Nutrients

      Volume: in press

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of the Factors Controlling the Abdominal Circumferences in Japanese High School Students Using the Bayesian Network2020

    • Author(s)
      Rie Horiuchi , Yuko Maki, Koichi Shirokoshi , Miki Tokunaga , Ram B. Singh , Douglas W. Wilson, Harpal S. Buttar , and Toru Takahashi
    • Journal Title

      Journal of Food and Nutrition

      Volume: in press

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Conditions for the appearance and Disappearance of dislikes of food in Japanese students2019

    • Author(s)
      R. Horiuchi1, Y. Maki, K. Shirokoshi, M. Tokunaga, RB. Singh, DW. Wilson, HS. Buttar, T. Takahashi
    • Journal Title

      Journal of Food and Nutrition

      Volume: 5 Pages: 1-8

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Influences of School Cooking and Catering Systems on Leftover Meals and Eating Behaviors of Children2018

    • Author(s)
      Rie Horiuchi, Yuko Maki, Miki Tokunaga, Yuko Yamamoto, Keiichi Tsukinoki, Ram B. Singh, Douglas W. Wilson, Harpal S. Buttar, and Toru Takahashi
    • Journal Title

      Journal of Food Nutrition and Dietetics.

      Volume: 5; 2 Pages: 1-1

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Therapy through Social Medicine: Cultivating Connections and Inspiring Solutions for Healthy Living,2017

    • Author(s)
      Douglas Wilson, Griffiths Keith, Buttar Harpal, Singh Ram, De Meester Fabien, Wilczynska Agnieszka, Toru Takahashi
    • Journal Title

      AIMS Medical Science

      Volume: 4 Issue: 2 Pages: 131-150

    • DOI

      10.3934/medsci.2017.2.131

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Increased subjective distaste and altered insula activity to umami in patients with bulimia nervosa2017

    • Author(s)
      R.Setsu, Y. Hirano, M.Tokunaga, T. Takahashi, N. Numata, K. Matsumoto, Y. Masuda, D. Matsuzawa, M.Iyo, E. Shimizu, M. Nakazato
    • Journal Title

      Front Psychiatry

      Volume: 8 Pages: 172-172

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Continuous combined intake of polydextrose and lactitol stimulates cecal fermentation and salivary IgA secretion in rats2017

    • Author(s)
      Y. Yamamoto, T.Takahahi, M.To, Y. Nakagawa, T. Hayashi, J. Saruta, K. Tsukinoki
    • Journal Title

      Journal of Oral Science

      Volume: 59 Issue: 4 Pages: 603-610

    • DOI

      10.2334/josnusd.16-0820

    • NAID

      130006286525

    • ISSN
      1343-4934, 1880-4926
    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Relationships between pathologic subjective halitosis, olfactory reference syndrome, and social anxiety in young Japanese women2017

    • Author(s)
      Miho Tsuruta, Toru Takahashi, Miki Tokunaga, Masanori Iwasaki, Shota Kataoka, Satoko Kakuta, Inho Soh, Shuji Awano, Hiromi Hirata, Masaharu Kagawa and Toshihiro Ansai
    • Journal Title

      BMC Psychology

      Volume: 14 Issue: 1 Pages: 1-1

    • DOI

      10.1186/s40359-017-0176-1

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Dietary Fiber2019

    • Author(s)
      T. Takahashi
    • Organizer
      19th World Congress on Clinical Nutrition, Armedabad, India
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 「Dirtary fibers」(招待講演)2018

    • Author(s)
      Takahashi et al/
    • Organizer
      World Congress of Clinical Nutrition
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 「Potential causal relationships between pathologic subjective halitosis and psychological characteristics」招待講演2018

    • Author(s)
      T Ansai et al.
    • Organizer
      Psychiatry & Psychology
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] オリゴ糖添加が唾液中IgA分泌速度に与える影響2018

    • Author(s)
      山本ら
    • Organizer
      第72回日本栄養・食糧学会大会
    • Related Report
      2018 Research-status Report
  • [Presentation] 脂肪添加量の違いとフラクトオリゴ糖添加が唾液中IgA分泌速度と顎下腺チロシンヒドロキシラーゼ濃度に与える影響2018

    • Author(s)
      山本ら
    • Organizer
      第24回Hindgut Club JAPAN シンポジウム
    • Related Report
      2018 Research-status Report
  • [Presentation] 教員の直接指導が園児の食事中の行動や残菜率に及ぼす影響2018

    • Author(s)
      堀内ら
    • Organizer
      65回日本栄養改善学会
    • Related Report
      2018 Research-status Report
  • [Presentation] 親のやせの認識と心理的要因が子供のやせに及ぼす影響2018

    • Author(s)
      堀内ら
    • Organizer
      第14回日本給食経営管理学会
    • Related Report
      2018 Research-status Report
  • [Presentation] Effect of free water in the intestinal lumen on glucose absorption2017

    • Author(s)
      Toru Takahashi, Miki Tokunaga, Rie Horiuchi, Ram B. Singh, Douglas W. Wilson,
    • Organizer
      World Congress of Clinical Nutrition
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Difference between “viscosity in physics” and viscosity used in food properties of intestinal contents2017

    • Author(s)
      Toru Takahashi, Koko Udagawa, Rie Horiuchi and Miki Tokunaga
    • Organizer
      国際栄養学会
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 消化管内容物の粘度測定のための管流式粘度計の開発2017

    • Author(s)
      高橋 徹  坂田 隆
    • Organizer
      日本栄養材形状機能研究会
    • Related Report
      2017 Research-status Report
  • [Presentation] X線透視動画と数学シミュレーションを用いた胃瘻造設患者の胃の流れおよび胃食道逆流の解明2017

    • Author(s)
      高橋徹、飯島 正平、徳永美希、村松博士
    • Organizer
      日本栄養食糧学会
    • Related Report
      2017 Research-status Report
  • [Book] Chapter 3, The Role of Functional Food Security in Global Health 1st Edition(編集:R.B.Singh, Ronald Watson、高橋徹)2018

    • Author(s)
      Toru Takahashi et al.
    • Publisher
      Academic press
    • Related Report
      2018 Research-status Report
  • [Book] Chapter 5, The Role of Functional Food Security in Global Health 1st Edition(編集:R.B.Singh, Ronald Watson、高橋徹)2018

    • Author(s)
      Rao SS et al.
    • Publisher
      Academic press
    • Related Report
      2018 Research-status Report
  • [Book] Chapter 6, The Role of Functional Food Security in Global Health 1st Edition(編集:R.B.Singh, Ronald Watson、高橋徹)2018

    • Author(s)
      J Fedacko et al.
    • Publisher
      Academic press
    • Related Report
      2018 Research-status Report
  • [Book] Chapter 14, The Role of Functional Food Security in Global Health 1st Edition(編集:R.B.Singh, Ronald Watson、高橋徹)2018

    • Author(s)
      S Watanabe et al.
    • Publisher
      Academic press
    • Related Report
      2018 Research-status Report
  • [Book] Chapter 17, The Role of Functional Food Security in Global Health 1st Edition(編集:R.B.Singh, Ronald Watson、高橋徹)2018

    • Author(s)
      V Mojito
    • Publisher
      Academic press
    • Related Report
      2018 Research-status Report
  • [Book] Dietary Fiber for Prevention of Cardiovascular Disease2017

    • Author(s)
      Divya R. Gunashekar, Singh RB, Mohammad A, Anand N, Shewale R, Takahashi T, et al.
    • Total Pages
      15
    • Publisher
      Academic press
    • Related Report
      2017 Research-status Report

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Published: 2017-04-28   Modified: 2022-02-28  

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