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Establishment of precision medicine for lifestyle-related diseases using the growth trajectory from fetal to adulthood

Research Project

Project/Area Number 17K01867
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Applied health science
Research InstitutionSaitama Medical University

Principal Investigator

Kikuchi Toru  埼玉医科大学, 医学部, 教授 (10240772)

Project Period (FY) 2017-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2018: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2017: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords生活習慣病 / 小児 / 郵送健診 / 追跡調査 / 肥満 / 脂質異常症 / トラッキング / 出生体重 / 成人式 / 血圧 / 成長 / 妊娠
Outline of Final Research Achievements

A Follow-up study of health check-up examination to prevent lifestyle disease by mail at Mitsuke city in Niigata Prefecture was performed. Thirty-six of the 306 people who had health check-up examinations in the 4th grade and turned 20 in 2019 participated in this study. This mail check-up examination tested total cholesterol, HDL- cholesterol, and LDL-cholesterol. The results of total and LDL cholesterol by mail examination at the age of 20 positively correlated with those at 4th grader by health check-up examination in school. These results revealed the tracking phenomenon of the risk factor of lifestyle diseases from child to adult, and importance to prevent lifestyle-related diseases from childhood. This mail check-up examination was useful for improvement on health of young adults.

Academic Significance and Societal Importance of the Research Achievements

本研究によって、体格や血清脂質が小学生から20歳までトラッキング現象があることが明らかになった。これは、小児期から生活習慣病予防健診などによる予防対策の有用性の根拠となる結果である。また、若年成人に対する郵送健診が、実施可能であった。若年成人は、健診会場で参加することが少ないため、郵送健診は有用であった。新たに新型コロナ感染症の蔓延に伴い、人との接触が不要な郵送健診の需要はさらに高まると考えられる。

Report

(6 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (37 results)

All 2022 2021 2020 2019 2018 2017

All Journal Article (5 results) (of which Peer Reviewed: 2 results) Presentation (30 results) (of which Int'l Joint Research: 5 results,  Invited: 20 results) Book (2 results)

  • [Journal Article] Pediatric hypertension based on Japanese Society of Hypertension Guidelines (JSH 2019) with actual school blood pressure screening data in Japan2022

    • Author(s)
      Kikudhi Toru
    • Journal Title

      Clinical and Experimental Pediatrics

      Volume: -

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 小児のメタボリックシンドローム2018

    • Author(s)
      菊池透
    • Journal Title

      小児保健研究

      Volume: 77 Pages: 564-566

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] 高血圧2018

    • Author(s)
      菊池透
    • Journal Title

      小児内科、増刊、小児疾患の診断治療基準

      Volume: 50 Pages: 194-195

    • Related Report
      2018 Research-status Report
  • [Journal Article] 生活習慣病に至る成長の軌跡2018

    • Author(s)
      菊池透
    • Journal Title

      新潟県医師会報

      Volume: 825 Pages: 2-7

    • Related Report
      2018 Research-status Report
  • [Journal Article] 糖代謝異常合併母体児の長期予後2018

    • Author(s)
      菊池透
    • Journal Title

      臨床婦人科産科

      Volume: 72 Pages: 1014-1017

    • Related Report
      2018 Research-status Report
  • [Presentation] DOHaDから広がる生活習慣予防2021

    • Author(s)
      菊池透
    • Organizer
      第94回 日本内分泌学会学術総会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 出生時胸囲と胸囲頭囲比は、小児期の収縮期血圧と逆相関する2021

    • Author(s)
      菊池透、小川洋平、阿部裕樹、武者育麻、川名宏、長崎啓祐
    • Organizer
      第10回日本DOHaD学会学術集会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 小児の脂質異常 小児期の脂質検査の意義について2021

    • Author(s)
      菊池透
    • Organizer
      第30回 日本脂質栄養学会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 新潟県見附市の小児生活習慣病健診における脂質異常に関する検討2021

    • Author(s)
      菊池透、小川洋平
    • Organizer
      第35回日本小児脂質研究会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 体幹および下肢水分量体重比と腹部脂肪量および過体重との逆相関関係2021

    • Author(s)
      菊池透、武者育麻、川名宏、小川洋平
    • Organizer
      第42回日本肥満学会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 小児生活習慣病健診の追跡健診として成人式の郵送健診の試み2020

    • Author(s)
      菊池透、武者育麻、川名宏、大竹明、小川洋平
    • Organizer
      第123回日本小児科学会学術集会
    • Related Report
      2020 Research-status Report
  • [Presentation] 小児肥満の各体格指標の比較2020

    • Author(s)
      菊池透 ,武者育麻,川名宏,小川洋平
    • Organizer
      第31回日本成長学会学術集会
    • Related Report
      2020 Research-status Report
  • [Presentation] 小児の腹囲増大に対して出生体重はU字分布を示す2020

    • Author(s)
      菊池透、小川洋平、長崎啓祐、川名宏、武者育麻
    • Organizer
      第93回 日本内分泌学会学術総会
    • Related Report
      2020 Research-status Report
  • [Presentation] 生活習慣病に至る子宮内環境から始まる成長の軌跡2020

    • Author(s)
      菊池透
    • Organizer
      第93回 日本内分泌学会学術総会
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] 小児肥満の各体格指標と収縮期血圧およびHDL-Cとの関連の比較2020

    • Author(s)
      菊池透、小川洋平、武者育麻、川名宏、長崎啓祐
    • Organizer
      第41回日本肥満学会
    • Related Report
      2020 Research-status Report
  • [Presentation] 小児肥満とその後のライフステージへの影響2020

    • Author(s)
      菊池透
    • Organizer
      第41回日本肥満学会
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] 妊娠糖尿病の児の将来2020

    • Author(s)
      菊池透
    • Organizer
      第36回日本糖尿病妊娠学会年次学術集会
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] Diagnostic criteria of pediatric hypertension in Japan: BP reference values, BP classification2020

    • Author(s)
      Kikuchi T
    • Organizer
      The 54th Annual Congress of the Korean Society of Hypertension
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] valuation and management of pediatric hypertension in Japan2020

    • Author(s)
      Kikuchi T
    • Organizer
      The 54th Annual Congress of the Korean Society of Hypertension
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 小児生活習慣病健診の追跡健診によるトラッキング現象の検討2019

    • Author(s)
      菊池透、武者育麻、川名宏、大竹明、小川洋平
    • Organizer
      第33回日本小児脂質研究会
    • Related Report
      2019 Research-status Report
  • [Presentation] 小児の高血圧2019

    • Author(s)
      菊池透
    • Organizer
      第8回臨床高血圧フォーラム
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 肥満小児の診方・味方2019

    • Author(s)
      菊池透
    • Organizer
      第122回日本小児科学会学術集会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] ガイドラインに基づく小児肥満症診療2019

    • Author(s)
      菊池透
    • Organizer
      第92回日本内分泌学会学術総会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 小児・思春期糖尿病の特徴と課題2019

    • Author(s)
      菊池透
    • Organizer
      第62回日本糖尿病学会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 小児肥満と動脈硬化2019

    • Author(s)
      菊池透
    • Organizer
      第51回 日本動脈硬化学会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 胎児期から始まる小児肥満への軌跡2019

    • Author(s)
      菊池透
    • Organizer
      第8回日本DOHaD学会学術集会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] AYA世代の肥満、糖尿病の治療2018

    • Author(s)
      菊池透
    • Organizer
      第91回日本内分泌学会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] Current status of childhood obesity and its guidelines for management in Japan2018

    • Author(s)
      菊池透
    • Organizer
      第36回肥満治療学会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 小児のメタボリックシンドローム2018

    • Author(s)
      菊池透
    • Organizer
      第65回日本小児保健協会学術集会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] Year Book 1糖尿病・肥満・脂質異常2018

    • Author(s)
      菊池透
    • Organizer
      第52回日本小児内分泌学会学術集会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 思春期の肥満の現状と対策2018

    • Author(s)
      菊池透
    • Organizer
      第39回肥満学会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] Metabolic syndrome: Pathogenesis, Diagnosis2018

    • Author(s)
      Kikuchi Toru
    • Organizer
      ISPAD Science School for Physicians 2018
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Rapid BMI gain during later infant accelerates skeletal maturationat prepubertal obese children2018

    • Author(s)
      Kikuchi Toru
    • Organizer
      European Society for Paediatric Endocrinology 2018
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] 幼児期後半のBMI増加は、学童期の骨年齢を促進させる2017

    • Author(s)
      菊池 透
    • Organizer
      第51回日本小児内分泌学会
    • Related Report
      2017 Research-status Report
  • [Presentation] Childhood obesity affects bone maturation and bone density2017

    • Author(s)
      菊池 透
    • Organizer
      International Congress on Obesity and Metabolic Syndrome (ICOMES) 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research / Invited
  • [Book] 糖尿病 最新の治療 2019-20212019

    • Author(s)
      門脇孝、荒木栄一、綿田裕孝 編集
    • Total Pages
      337
    • Publisher
      南江堂
    • ISBN
      9784524245567
    • Related Report
      2018 Research-status Report
  • [Book] 妊婦の糖代謝異常 診療・管理マニュアル 改訂第2版2018

    • Author(s)
      日本糖尿病・妊娠学会編
    • Total Pages
      210
    • Publisher
      メジカルレビュー社
    • Related Report
      2018 Research-status Report

URL: 

Published: 2017-04-28   Modified: 2023-01-30  

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