| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Outline of Final Research Achievements |
Dipeptidyl-peptidase 4 (DPP4) cleaves and inactivates the incretin hormones that decrease blood glucose levels. It was reported that intake of fish and EPA or DHA increases the effect of DPP4 inhibitor and improves HbA1c levels. It was also suggested that EPA or DHA may reduce DPP4 activity, however it has not been clarified. It is thus necessary to directly determine the role of fatty acids in regulating DPP4. Therefore, we examined the effect of fatty acids on DPP4 activity in vitro and pancreatic β cells to construct an evidence for new diet-based therapy for diabetes. This study suggests that fatty acids have the potential to inhibit DPP4 activity and enhance the effect of DPP4 inhibitors. Fatty acids such as EPA and DHA, which have an especially strong inhibitory effect on DPP4 activity, may be effectively used in a new diet-based therapy for diabetes.
|
