| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2018: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2017: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
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| Outline of Final Research Achievements |
The radiation sensitivity of fetus is considered high, but there is no consensus about the cancer risk following radiation exposure in fetal period. Because radiation carcinogenesis in humans is considered to result from the combined effect of radiation and environmental carcinogens, exposure to environmental carcinogens after birth may affect the cancer risk following irradiation.
This study was aimed to evaluate the carcinogenic risk following fetal irradiation and postnatal chemical carcinogens exposure. We analyzed the tumor spectrum of fetal radiation exposure in combination with postnatal administration of chemical carcinogen by histopathological examination. The incidence of lung tumor in the combined exposure group was equivalent to that of chemical carcinogen alone, and the effect of combined exposure was not observed. In this study, the effect of prenatal radiation exposure on the carcinogenesis of chemical carcinogens exposed after birth was not observed.
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