| Project/Area Number |
17K01943
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Biomolecular chemistry
|
|---|
| Research Institution | Tokyo Institute of Technology |
|---|
Principal Investigator |
Mamajanov Irena 東京工業大学, 地球生命研究所, 特任教授 (80776261)
|
|---|
| Project Period (FY) |
2017-04-01 – 2021-03-31
|
| Project Status |
Completed (Fiscal Year 2020)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2017: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
|
|---|
| Keywords | origin of life / chemical evolution / hyperbranched polymers / protoenzymes / hyperbranched polymer / polyester / wet-dry cycle / smart material / protoenzyme / biomimetic catalysis / hyperbranched polyesters / biomimetic catalysts / 生物活性物質の探索 / prebiotic chemistry |
|---|
| Outline of Final Research Achievements |
1) Branched polyesters undergo chemical evolution under wet-dry cycles to form soluble hyperbranched structures. Cross-linked structures form without wet-dry cycling. 2) Hyperbranched polyesters are capable of supporting nanoparticles and form biomimetic enzyme-like catalysts. The systems has been tested for ZnS nanocrystals relevant to Zn World origin of life scenario. 3) Utilizing ester amide exchange reaction, we have shown that hyperbranched polyesters provide a template for non-random incorporation of amino acids into a depsipeptides suggesting the possible pathway to functional peptides in prebiotic chemistry. 4) Polyesters serve as membraneless compartments capable of encapsulating functional RNA.6) A new insight into origins of life: it would have been more efficient for species to form prior to the origin of life
|
| Academic Significance and Societal Importance of the Research Achievements |
For 70 years the origin of life field has been focused on the synthesis of biological molecules. The synthesis of biomolecules does not lead to the formation of life. It is important to look into dynamic processes of functional systems. This project successfully explored one such system.
|
