Synthetic study of terpenoid for anti-cancer drug and its molecular probe
Project/Area Number |
17K01952
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Biomolecular chemistry
|
Research Institution | Yokohama College of Pharmacy |
Principal Investigator |
Shoji Mitsuru 横浜薬科大学, 薬学部, 教授 (30339139)
|
Project Period (FY) |
2017-04-01 – 2020-03-31
|
Project Status |
Completed (Fiscal Year 2019)
|
Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | ジテルペン / 抗腫瘍活性 / 全合成 / コチレニン / テルペン / 配糖体 |
Outline of Final Research Achievements |
Cotylenin A was isolated from unidentified fungus and it is a highly potent anti-cancer drug candidate with low toxicity. The fungus does not produce cotylenin A now and its chemical synthesis is highly desirable. We prepared the three parts of cotylenin A and its supply is now in progress.
|
Academic Significance and Societal Importance of the Research Achievements |
新薬候補化合物として期待されている天然物コチレニンAが化学合成で供給できるようになれば、高い活性を持ちながら副作用の少ない新しい抗がん剤を開発することができる。本研究では、コチレニンAの3つの部位に分割し、それぞれを合成し、全合成達成への道を拓いた。コチレニンAを化学合成できるようになれば、量的供給が可能になり、新薬開発が期待される。
|
Report
(4 results)
Research Products
(7 results)