Elucidation of elastin crosslinking structure and preparation of antigen/antibody of desmosines
| Project/Area Number |
17K01953
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biomolecular chemistry
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| Research Institution | Sophia University |
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Principal Investigator |
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| Project Period (FY) |
2017-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | エラスチン / desmosine / デスモシン / 抗原 / 環状ペプチド / 有機化学 / 生体分子 / 蛋白質 |
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| Outline of Final Research Achievements |
Elastin has crosslinking structure with desmosines. The first total synthesis of desmosines have been achieved in our group using cross-coupling reactions as well as Chichibabin pyridinium synthesis.
In this study, based on the established synthetic strategy, cyclic peptides with desmosine have been accomplished. In addition, preparation of antigen of isodesmosine was carried out.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究の遂行によって、エラスチンの分解をともなうCOPD（慢性閉塞性肺疾患）や動脈瘤、皮膚疾患などの疾患に対するバイオマーカー診断法の確立へつながる。
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Report
(4 results)
Research Products
(96 results)
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[Presentation] Synthetic Study toward Cyaropicrin2018
Author(s)
Temma Nakamura, Kougaku Kimura, Dinda B. Pitna, Shoya Yamaguchi, Tomoya Uchiyama, Toyonobu Usuki
Organizer
The 14th International Kyoto Conference on New Aspects of Organic Chemistry (IKCOC-14)
Related Report
Int'l Joint Research
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