| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
The function of the living body is caused by that the ligand specifically bind to the receptor. The development of receptor-specific molecular probes is not only to clarifying the function of receptors, but also is directly linked to the elucidation both of the cause of diseases and drug discovery. In this study, the author investigated the relationship between the structure and biological activity of the functional peptides found by screening the synthetic peptide library (laminin peptide library) covering the amino acid sequence of laminin, which is a member of the basement membrane. We analyzed the structure-activity relationship of these peptides and further modifyed them chemically to develop a receptor-specific molecular probe.
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