Development of receptor-specific molecular probe using functional peptides
Project/Area Number |
17K01954
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Biomolecular chemistry
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Research Institution | Tokyo University of Pharmacy and Life Science |
Principal Investigator |
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Project Period (FY) |
2017-04-01 – 2020-03-31
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Project Status |
Completed (Fiscal Year 2019)
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Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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Keywords | ペプチド / 遊走 / 受容体 / ケミカルバイオロジー / 受容体探索 / ラミニン |
Outline of Final Research Achievements |
The function of the living body is caused by that the ligand specifically bind to the receptor. The development of receptor-specific molecular probes is not only to clarifying the function of receptors, but also is directly linked to the elucidation both of the cause of diseases and drug discovery. In this study, the author investigated the relationship between the structure and biological activity of the functional peptides found by screening the synthetic peptide library (laminin peptide library) covering the amino acid sequence of laminin, which is a member of the basement membrane. We analyzed the structure-activity relationship of these peptides and further modifyed them chemically to develop a receptor-specific molecular probe.
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Academic Significance and Societal Importance of the Research Achievements |
著者らは、ラミニンペプチドライブラリーから見出された機能性ペプチドをリポソームに結合させてDDSへの応用、高分子多糖に結合させて組織工学などへの応用を既に報告しており、その有用性が証明されている。本研究課題の成果は、疾患の原因解明に役立つ分子プローブを提供できたり、医薬品の候補化合物を提案できたりするだけでなく、ES細胞やiPS細胞の機能維持機構の解明、さらには安定した培養条件の確立などにも応用でき、再生医療にも応用できるものと期待される。
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Report
(4 results)
Research Products
(21 results)
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[Journal Article] Sensitive and selective quantification of mid-regional proadrenomedullin in human plasma using ultra-performance liquid chromatography coupled with tandem mass spectrometry.2020
Author(s)
Iwao M, Suzuki Y, Tanaka R, Koyama T, Ozaki E, Nakata T, Aoki K, Fukuda A, Sato Y, Kuriyama N, Fukunaga N, Sato F, Katagiri F, Ohno K, Shibata H, Mimata H, Itoh H.
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Journal Title
J Pharm Biomed Anal.
Volume: 183
Pages: 113168-113168
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Internalization of CD239 Highly Expressed in Breast Cancer Cells: a Potential Antigen for Antibody-drug Conjugates.2018
Author(s)
Yamato Kikkawa, Yurie Enomoto-Okaw, Aiko Fujiyama, Takeshi Fukuhara, Nozomi Harashima, Yumika Sugawara, Yoichi Negishi, Fumihiko Katagiri, Kentaro Hozumi, Motoyoshi Nomizu, and Yuji Ito
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Journal Title
Sci Rep
Volume: 8
Pages: 6612-6612
Related Report
Peer Reviewed / Open Access
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[Journal Article] Identification of laminin α5 short arm peptides active for endothelial cell attachment and tube formation.2017
Author(s)
Kikkawa, Y., Sugawara, Y., Harashima, N., Fujii, S., Ikari, K., Kumai, J., Katagiri, F., Hozumi, K., and Nomizu, M.
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Journal Title
Journal of Peptide Science
Volume: 印刷中
Issue: 7-8
Pages: 666-673
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Presentation] Characterization of dystroglycan binding in adhesion of human induced pluripotent stem cells to laminin-511 E8 fragment2019
Author(s)
Y. Kikkawa, Y. Sugawara, K. Hamada, Y. Yamada, J. Kumai, M. Kanagawa, K. Kobayashi, T. Toda, Y. Negishi, F. Katagiri, K. Hozumi, M. Nomizu
Organizer
ASCB/EMBO 2019 meeting
Related Report
Int'l Joint Research
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