Synthesis of bioactive sugar chains using next-generation synthetic method and creation of medical application technology
| Project/Area Number |
17K01963
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Chemical biology
|
|---|
| Research Institution | Wakayama University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2017-04-01 – 2020-03-31
|
| Project Status |
Completed (Fiscal Year 2019)
|
| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
|---|
| Keywords | 糖鎖 / オリゴ糖 / 医療応用 / 機能性食品 / 生理活性糖鎖 / 生理活性 |
|---|
| Outline of Final Research Achievements |
Carbohydrate chains control vital life phenomena such as cell-cell recognition, information transmission, differentiation, proliferation, and immune response, which are essential for sustaining life. Carbohydrate chains are wide-ranging and are applied to medicines, foods, cosmetics and the like. A variety of carbohydrate chains are required in order to elucidate their functions, but their synthesis is difficult, and it is currently difficult to supply them sufficiently. In the present study, solves the problem by further developing the "next generation synthesis method" that has been developed. We have comprehensively synthesized oligosaccharide chains and their probes that are essential for elucidating the biological phenomena related to oligosaccharides. Using these carbohydrate chains, drugs, medical application technology, and functional foods were developed.
|
| Academic Significance and Societal Importance of the Research Achievements |
現時点ではその効果が立証されているにも関わらず、その限定された供給源や生産量、さらに価格面から限られた領域でしか使用されていない糖鎖類が非常に多く存在する。本研究では、これらの糖鎖を恒常的、簡便、大量、かつ安価に供給できる合成手法の開発に着手し、多くの生理活性糖鎖の合成と供給方法の開発に成功した。このことは、糖鎖と病気の関連性を解明でき、糖鎖を用いた新しい治療薬や治療法の開発が可能となり、社会への還元に向けた役割を大きく担える。
|
Report
(4 results)
Research Products
(22 results)
-
-
[Journal Article] Identification and characterization of a sulfoglycosidase from Bifidobacterium bifidum implicated in mucin glycan utilization2017
Author(s)
Katoh T, Maeshibu T, Kikkawa K, Gotoh A, Tomabechi Y, Nakamura M, Liao WH, Yamaguchi M, Ashida H, Yamamoto K, and Katayama T
-
Journal Title
Bioscience Biotechnology and Biochemistry
Volume: ８１（１０）
Pages: 2018-2027
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
[Presentation] Ｖirucidal Activities of Proteoglycans Prepared with Umezu, a Salt-Extract of Japanese Apricot2017
Author(s)
Ikeda, K., Yamaguchi, M., Nagao, T., Nishide, M., Yamaguchi, Masanori, Kuwahara, T., Koyama, A. H
Organizer
International Union of Microbiological Societies(IUMS)2017
Related Report
Int'l Joint Research
-
-
-
-
-
-
-
-
-
-
