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Screening of cancer cell 3D invasion inhibitors from microbial metabolites

Research Project

Project/Area Number 17K01967
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Chemical biology
Research InstitutionAichi Medical University

Principal Investigator

Umezawa Kazuo  愛知医科大学, 医学部, 教授 (70114402)

Co-Investigator(Kenkyū-buntansha) 小出 直樹  愛知医科大学, 医学部, 教授 (50308962)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywordsがん細胞 / 三次元培養 / 遊走 / 浸潤 / NF-kappa B / I-kappa B kinase / ketomycin / DHMEQ / 転移 / 放線菌 / スクリーニング / IKK-beta / 生理活性物質 / 微生物 / 阻害剤
Outline of Final Research Achievements

In the present research, we have screened low molecular weight compounds that inhibit cancer cell migration from microbial culture filtrates and our own chemical library, then, we have evaluated their effect on three-dimensional (3D) invasion. As a result, we found NF-kappa B inhibitor DHMEQ, migracinal that is a novel derivative of migracin, terfestatin D that is novel microbial metabolite, and a known antibiotic ketomycin as inhibitors of two-dimensional (2D) migration and invasion. Among them, DHMEQ and ketomycin were found to inhibit 3D invasion of cancer cells, and we looked into the mechanism of inhibition. The mechanistic study has shown that ketomycin is a new inhibitor of I-kappa B kinase.

Academic Significance and Societal Importance of the Research Achievements

学術的意義として、新規化合物p-terphenyl glycosideのterfestatin Dとmigracinalを発見し、ketomycinに新規活性を見出した。一方、DHMEQや浸潤を阻害するconophyllineにおいては疾患に関与する多くの新規活性を見出した。社会的意義として、ほとんどの成果を論文および学会発表して知見を社会に広めた。また、海外の大学と多くの共同研究を行って研究のグローバル化を推進させた。さらに3D浸潤は2D浸潤より臨床上の転移に近いモデルとされ、3D浸潤を阻害するDHMEQとketomycinは毒性の少ない抗がん剤として発展する可能性がある。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (72 results)

All 2020 2019 2018 2017 Other

All Int'l Joint Research (12 results) Journal Article (30 results) (of which Int'l Joint Research: 13 results,  Peer Reviewed: 29 results,  Open Access: 4 results) Presentation (22 results) (of which Int'l Joint Research: 5 results,  Invited: 3 results) Remarks (6 results) Patent(Industrial Property Rights) (2 results)

  • [Int'l Joint Research] Poznan University of Medical Sciences(ポーランド)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] Shenzhen University/Shenyang Pharmaceutical University(中国)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] Queensland University of Technology(オーストラリア)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] University of Halle(ドイツ)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] University of San Francisco(ブラジル)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] Poznan University of Medical Sciences(ポーランド)

    • Related Report
      2018 Research-status Report
  • [Int'l Joint Research] Shenzhen University/Shenyang Pharmaceutical University(中国)

    • Related Report
      2018 Research-status Report
  • [Int'l Joint Research] University of Bergen(ノルウェー)

    • Related Report
      2018 Research-status Report
  • [Int'l Joint Research] Bashkortostan State Medical University(ロシア連邦)

    • Related Report
      2018 Research-status Report
  • [Int'l Joint Research] University of Bergen(Norway)

    • Related Report
      2017 Research-status Report
  • [Int'l Joint Research] Shenyang Pharmaceutical University/Shenzhen University(China)

    • Related Report
      2017 Research-status Report
  • [Int'l Joint Research] University of Freiburg(Germany)

    • Related Report
      2017 Research-status Report
  • [Journal Article] Inhibition of matrix metalloproteinase expression and cellular invasion by NF-κB inhibitors of microbial origin2020

    • Author(s)
      K. Umezawa, Y. Lin
    • Journal Title

      BBA-Proteins and Proteomics 1868 (2020) 140412

      Volume: in press

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of cellular inflammatory mediator production and amelioration of learning deficit in flies by deep sea Aspergillus-derived cyclopenin2020

    • Author(s)
      L. Wang, M. Li, Y. Lin, S. Du, Z. Liu, J. Ju, H. Suzuki, M. Sawada, K. Umezawa
    • Journal Title

      J. Antibiot.

      Volume: in press Issue: 9 Pages: 622-629

    • DOI

      10.1038/s41429-020-0302-9

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Direct and indirect anticancer activity of plant-derived alkaloid conophylline2020

    • Author(s)
      K. Umezawa, K. Shirabe
    • Journal Title

      Critical Reviews in Oncogenesis

      Volume: in press Issue: 2 Pages: 67-72

    • DOI

      10.1615/critrevoncog.2020034129

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dehydroxymethylepoxyquinomicin, a novel nuclear factor-κB inhibitor, prevents the development of cyclosporine A nephrotoxicity in a rat model2020

    • Author(s)
      S. Morita, K. Shinoda, T. Yoshida, M. Shimoda, Y. Kanno, R. Mizuno, H. Kono, H. Asanuma, K. Nakagawa, K. Umezawa, M. Oya
    • Journal Title

      BMC Pharmacology and Toxicology

      Volume: in press

    • DOI

      10.21203/rs.2.21990/v2

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Anti-Inflammatory effect of Dehydroxymethylepoxyquinomicin, a nuclear factor-kappa B inhibitor, on endotoxin-induced uveitis in rats in vivo and in vitro2019

    • Author(s)
      Y. Ando, H. Keino, A. Kudo, A. Hitrakata, A. A. Okada, K. Umezawa
    • Journal Title

      Occular Immunology & Inflammation

      Volume: in press Issue: 2 Pages: 240-248

    • DOI

      10.1080/09273948.2019.1568502

    • Related Report
      2019 Annual Research Report 2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] The JAK/STAT3 and NF-kappa B signaling pathways regulate cancer stem cell properties in anaplastic thyroid cancer cells2019

    • Author(s)
      K. Shiraiwa, M. Mitsutake, Y. Nakazawa, T. Ogi, K. Suzuki, V. Saenko, K. Umezawa, S. Yamashita, K. Tsukamoto
    • Journal Title

      Thyroid

      Volume: in press Issue: 5 Pages: 674-682

    • DOI

      10.1089/thy.2018.0212

    • Related Report
      2019 Annual Research Report 2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Growth inhibitory effects of dipotassium glycyrrhizinate in glioblastoma cell lines by targeting microRNAs through the NF-κB signaling pathway2019

    • Author(s)
      G. A. Bonafe, J. S. dos Santos, J. V. Ziegler, K. Umezawa, M. L. Ribeiro, T. Rocha, M. M. Ortega
    • Journal Title

      Frontiers in Cellular Neuroscience

      Volume: 13

    • DOI

      10.3389/fncel.2019.00216

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Causes and mechanisms of peritoneal fibrosis and possible application of NF-κB inhibitor for prevention and treatment2019

    • Author(s)
      A. Breborowicz, K. Umezawa
    • Journal Title

      Journal of Medical Science

      Volume: 88 Issue: 2 Pages: 102-108

    • DOI

      10.20883/jms.352

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] The differential statin effect on cytokine production of monocytes or macrophages is mediated by differential geranylgeranylation-dependent Rac1 activation2019

    • Author(s)
      H. Fu, M. Alabdullah, J. Grosmann, F. Spieler, R. Abdosh, V. Lutz, K. Kalies, K. Knopp, K. Rieckmann, S. Koch, M. Nutsias, C. Pilowski, J. Dutzmann D. Sedding, S. Huttelmaier, K. Umezawa, K. Werdan, H. Loppnow
    • Journal Title

      Cell Death and Disease

      Volume: 10 Issue: 12 Pages: 880-880

    • DOI

      10.1038/s41419-019-2109-9

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Targeting NF-κB-mediated inflammatory pathways in cisplatin-resistant NSCLC2019

    • Author(s)
      S.-L. Ryan, S. Beard, M. P. Barr, K. Umezawa, S. Heavey, P. Godwin, S. G. Gray, D. Cormican, S. P. Finn, K. A. Gately, A. M. Davies, E. W. Thompson, D. J. Richard, K. J. O’Byrne, M. N. Adams, A.-M. Baird
    • Journal Title

      Lung Cancer

      Volume: 135 Pages: 217-227

    • DOI

      10.1016/j.lungcan.2019.07.006

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Isolation of ketomycin from Actinomycetes as an inhibitor of 2D and 3D cancer cell invasion2019

    • Author(s)
      Y. Lin, Y. Chen, T. Ukaji, S. Okada, K. Umezawa
    • Journal Title

      J. Antibiot.

      Volume: 72 Pages: 148-154

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Conophylline suppresses pancreatic cancer desmoplasia and cancer-promoting cytokines produced by cancer-associated fibroblasts2019

    • Author(s)
      N. Ishii, K. Araki, T. Yokobori, K. Hagiwara, G. Dolgormaa, T. Yamanaka, T. Handa, M. Tsukagoshi, T. Igarashi, A. Watanabe, N. Kubo, N. Harimoto, A. Masamune, K. Umezawa, H. Kuwano, K. Shirabe
    • Journal Title

      Cancer Science

      Volume: 10 Issue: 1 Pages: 334-434

    • DOI

      10.1111/cas.13874

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Comparison of anti-atopic dermatitis activities between DHMEQ and tacrolimus ointments in mouse model without stratum corneum2019

    • Author(s)
      H. He, X. Gao, X. Wang, X. Li, X. Jiang, Z. Xie, K. Ma, J. Ma, K. Umezawa, Y. Zhang
    • Journal Title

      International Immunopharmacology

      Volume: 71 Pages: 43-51

    • DOI

      10.1016/j.intimp.2019.03.015

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Dehydroxymethylepoxyquinomicin suppresses atopic dermatitis-like lesions in a stratum corneum-removed murine model through NF-kappa B inhibition2018

    • Author(s)
      X. Jiang, H. He, Z. Xie, H. Wen, X. Li, Xin Li, J. Ma, K. Umezawa, Y. Zhang
    • Journal Title

      Immunopharmacology and Immunotoxicology

      Volume: in press Issue: 1 Pages: 32-39

    • DOI

      10.1080/08923973.2018.1510962

    • Related Report
      2019 Annual Research Report 2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] NF-κB inhibitor DHMEQ inhibits titanium dioxide nanoparticle-induced interleukin-1β production: Inhibition of the PM2.5-induced inflammation model.2018

    • Author(s)
      Fukatsu H, Koide N, Tada-Oikawa S, Izuoka K, Ikegami A, Ichihara S, Ukaji T, Morita N, Naiki Y, Komatsu T, Umezawa K.
    • Journal Title

      Mol Med Rep

      Volume: 18 Pages: 5279-5285

    • DOI

      10.3892/mmr.2018.9533

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Conophylline inhibits high fat diet-induced non-alcoholic fatty liver disease in mice2018

    • Author(s)
      T. Ohashi, Y. Nakade, M. Ibusuki, R Kitano, T. Yamauchi, S. Kimoto, T. Inoue, Y. Kobayashi, N. Ishii, Y. Sumida, K. Ito, H. Nakao, K. Umezawa, M. Yoneda
    • Journal Title

      PLOS One

      Volume: electronic Issue: 1 Pages: e0210068-e0210068

    • DOI

      10.1371/journal.pone.0210068

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The plant alkaloid conophylline inhibits matrix formation of fibroblasts2018

    • Author(s)
      T. Tezuka, A. Ota, S. Karnan, K. Matsuura, K. Yokoo, Y. Hosokawa, D. Vigetti, A. Passi, S. Hatano, K. Umezawa, H. Watanabe
    • Journal Title

      J. Biol. Chem.

      Volume: 293 Pages: 20214-20226

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Therapeutic activity of plant-derived alkaloid conophylline on metabolic syndrome and neurodegerative disease models2018

    • Author(s)
      K. Umezawa, I. Kojima, S. Simizu, Y. Lin, H. Fukatsu, N. Koide, Y. Nakade and M. Yoneda
    • Journal Title

      Human Cell

      Volume: 31 Pages: 95-101

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Inhibition of late and early phases of cancer metastasis by NF-κB inhibitor DHMEQ derived from microbial bioactive metabolite epoxyquinomicin: A review.2018

    • Author(s)
      Y. Lin, T. Ukaji, N. Koide and K. Umezawa
    • Journal Title

      Int. J. Mol. Sci.

      Volume: - Issue: 3 Pages: 729-729

    • DOI

      10.3390/ijms19030729

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] DTCM-glutarimide delays growth and radiosensitizes glioblastoma.2018

    • Author(s)
      G. BM. Roberto, H. H. Paiva, L. E. B. deSouza, J. A. Pezuk, G. M. Vieira, H. F. deOliveira, K. Umezawa, L. G. Tone and M. S. Brassesco
    • Journal Title

      Anti-cancer Agents in Medicinal Chemistry

      Volume: - Issue: 9 Pages: 1323-1329

    • DOI

      10.2174/1871520618666180423105740

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Rational design, synthesis and in vitro evaluation of novel exo-methylene butyrolactone salicyloylamide as NF-κB inhibitor.2017

    • Author(s)
      K. Sidthipong, J. Ma, W. L. Yu, Y. F. Wang, S. Kobayashi, S. Kishino , N. Koide, T. Yokochi, K. Kato, S. Okada and K. Umezawa
    • Journal Title

      Bioorg. Med. Chem. Lett.

      Volume: 27 Pages: 562-567

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Thrombomodulin blocks calcineurin inhibitor-induced vascular permeability via inhibition of Src/VE-cadherin axis.2017

    • Author(s)
      T. Ikezoe, J. Yang, C. Nishioka, K. Umezawa and A. Yokoyama
    • Journal Title

      Bone Marrow Transplantation

      Volume: 52 Pages: 245-251

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Inhibition of MMP-2-mediated cellular invasion by NF-kappa B inhibitor DHMEQ in 3D culture of breast carcinoma MDA-MB-231 cells: A model for early phase of metastasis.2017

    • Author(s)
      T. Ukaji, Y. Lin, S. Okada and K. Umezawa
    • Journal Title

      Biochem. Biophys. Res. Commun.

      Volume: 485 Pages: 76-81

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Abnormal differentiation of stem cells into enteroendocrine cells in rats with DSS-induced colitis.2017

    • Author(s)
      M. El-Salhy, K. Umezawa, J. G. Hatlebakk and O. H. Gilja
    • Journal Title

      Mol. Med. Reports

      Volume: 15 Pages: 2106-2112

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] External application of NF-κB inhibitor DHMEQ suppresses development of atopic dermatitis-like lesions induced with DNCB/OX in BALB/c mice.2017

    • Author(s)
      X. Jiang, B. Wei, Y. Lan, C. Dai, Y. Gu, J. Ma, X. Liu, K. Umezawa and Y. Zhang
    • Journal Title

      Immunopharmacology and Immunotoxicology

      Volume: 39:3 Pages: 157-164

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Novel p-terphenyl glycoside with a rare 2,6-dideoxy- hexopyranose moiety from Actinomycete strain SF2911 that inhibits cancer cell migration.2017

    • Author(s)
      L. Wang, M. Li, J. Tang, Y. Y. Lin, K. Sidthipong, N. Sumida, N. Kushida and K. Umezawa
    • Journal Title

      J. Antibiot.

      Volume: 70 Pages: 987-990

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Conophylline inhibits non-alcoholic steatohepatitis in mice.2017

    • Author(s)
      Y. Nakade, K. Sakamoto, T. Yamauchi, Tadahisa Inoue, Y. Kobayashi, T. Yamamoto, N. Ishii, T. Ohashi; Y. Sumida; K. Ito, H. Nakao, Y. Fukuzawa, K. Umezawa and M. Yoneda
    • Journal Title

      PLOS One

      Volume: 12(6)

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] The microenvironmental stromal cells abrogate NF-κB inhibitor induced apoptosis in chronic lymphocytic leukemia2017

    • Author(s)
      C-P. Simon-Gabriel, K. Foerster, M. Benkisser-Petersen, D. Bleckmann, N. Thornton, K. Umezawa, S. Decker, C. Dierks, M. Burger, H. Veelken, R. Claus, J. Duyster, K. Zirlik
    • Journal Title

      Hematologica

      Volume: - Issue: 1 Pages: 136-147

    • DOI

      10.3324/haematol.2017.165381

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Molecular design of sugar-free migracin analog migracinal that inhibits ovarian cancer cell migration and invasion.2017

    • Author(s)
      T. Ukaji, N. Koide, Y. Lin, K. Banno, S. Gantsev and K. Umezawa
    • Journal Title

      Creative Surgery and Oncology

      Volume: 7 (4) Pages: 16-20

    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Journal Article] The unfolded protein response mediated by PERK is casually related to the pathogenesis of intervertebral disc degeneration.2017

    • Author(s)
      T. Fujii, N. Fujita, S. Suzuki, K. Watanabe, T. Tsuji, K. Ishii, T. Takaki, K. Umezawa, T. Miyamoto, K. Horiuchi, M. Matsumoto, M. Nakamura
    • Journal Title

      Journal of Orthopaedic Research

      Volume: - Issue: 5 Pages: 1334-1345

    • DOI

      10.1002/jor.23787

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Presentation] クマササ含有成分および誘導体によるLPSに誘導される炎症反応の抑制2020

    • Author(s)
      林音知、深津仁見、小嶋しおり、梅澤一夫、小出直樹
    • Organizer
      第93回日本細菌学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 深海カビAspergillusが産生するcyclopeninによる炎症誘起因子発現の抑制とハエ学習障害モデルの改善。2019

    • Author(s)
      林音知、王立岩、Wu Yanhua、小出直樹、梅澤一夫
    • Organizer
      新規素材探索研究会第18回セミナー
    • Related Report
      2019 Annual Research Report
  • [Presentation] 新しいI-κB kinase β阻害剤ketomycinによる細胞の遊走・浸潤および炎症性サイトカイン産生の抑制。2019

    • Author(s)
      Lin Yinzhi、杉浦信夫、小嶋しおり、小出直樹、梅澤一夫
    • Organizer
      第14回日本ケミカルバイオロジー学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 新しいI-κB kinase β阻害剤ketomycinによる乳がん細胞の遊走・浸潤およびヒト臍帯静脈内皮細胞管腔形成の抑制。2019

    • Author(s)
      Lin Yinzhi、小嶋しおり、梅澤一夫
    • Organizer
      第23回がん分子標的治療学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] クマササ含有成分および誘導体によるLPS作用の阻害。2019

    • Author(s)
      Lin Yinzhi、深津仁見、小嶋しおり、梅澤一夫、小出直樹
    • Organizer
      第65回トキシンシンポジウム
    • Related Report
      2019 Annual Research Report
  • [Presentation] NF-κB阻害剤DHMEQによるマウス形質細胞腫の細胞浸潤抑制と抗がん剤感受性の増強。2019

    • Author(s)
      Lin Yinzhi、小出直樹、梅澤一夫
    • Organizer
      第78回日本癌学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Role of peritoneal NF-κB on cancer and inflammation2019

    • Author(s)
      Kazuo Umezawa
    • Organizer
      Medical Forum in Shymkent, Kazakhstan
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Inhibition of titanium dioxide nanoparticle-induced inflammatory reaction by NF-κB inhibitor DHMEQ in human macrophage-like cells2018

    • Author(s)
      Hitomi Fukatsu, Tamami Ukaji, Saeko Tada-Oikawa, Kiyora Izuoka, Yoshikazu Naiki, Takayuki Komatsu, Naoki Koide, Akihiko Ikegami, Sahoko Ichihara, Kazuo Umezawa
    • Organizer
      21st International Symposium on Molecular Medicine
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Amelioration of metabolic syndrome and neurodegenerative disease models by plant-derived alkaloid conophylline2018

    • Author(s)
      Kazuo Umezawa
    • Organizer
      21st International Symposium on Molecular Medicine
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] がん細胞の遊走を阻害する放線菌由来ketomycinのスクリーニングと乳がんMDA-MB-231細胞における2Dおよび3D浸潤の抑制2018

    • Author(s)
      Lin Yinzhi、梅澤一夫
    • Organizer
      第22回がん分子標的治療学会
    • Related Report
      2018 Research-status Report
  • [Presentation] 新規NF-κB阻害剤SEMBLによる骨肉腫細胞および線維肉腫細胞に対する抗腫瘍効果2018

    • Author(s)
      松尾俊宏,梅澤一夫,松井卓哉,佐藤啓二,河南勝久,出家正隆
    • Organizer
      第91回日本整形外科学会学術総会
    • Related Report
      2018 Research-status Report
  • [Presentation] PM2.5モデルTiO2ナノ粒子に誘導されるマクロファージのIL-1 beta産生とNF-kappa B阻害剤DHMEQによる抑制2018

    • Author(s)
      深津仁見、梅澤一夫、森田奈央子、内記良一、小松孝行、小出直樹
    • Organizer
      新規素材探索研究会第17回セミナー
    • Related Report
      2018 Research-status Report
  • [Presentation] 放線菌由来細胞遊走阻害剤ketomycinの単離と乳がん細胞におけるMMP依存性浸潤の抑制2018

    • Author(s)
      Lin Yinzhi、Wu Yanhua、梅澤一夫
    • Organizer
      第13回日本ケミカルバイオロジー学会
    • Related Report
      2018 Research-status Report
  • [Presentation] Isolation of ketomycin from Streptomyces as an inhibitor of 2D and 3D invasion of human breast carcinoma cells2018

    • Author(s)
      Yinzhi Lin, Yanhua Wu, Kazuo Umezawa
    • Organizer
      第77回日本癌学会
    • Related Report
      2018 Research-status Report
  • [Presentation] Discovery, mechanism of action, and therapeutic activity of NF-kappa B inhibitor DHMEQ2018

    • Author(s)
      Kazuo Umezawa
    • Organizer
      Conference “Future of Oncology is Laid Today”(招待講演)(国際学会)
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] NF-κB阻害剤DHMEQによるナノ粒子誘導IL-1β産生の抑制2017

    • Author(s)
      深津仁見、宇梶珠、及川佐枝、出岡、市原佐保、小出直樹、梅澤一夫
    • Organizer
      第12回日本ケミカルバイオロジー学会 2017.6.7-9
    • Related Report
      2017 Research-status Report
  • [Presentation] migracin脱糖アルデヒド体migracinalによる卵巣がん細胞遊走・浸潤の抑制2017

    • Author(s)
      宇梶珠未、林音知、梅澤一夫
    • Organizer
      第21回がん分子標的治療学会
    • Related Report
      2017 Research-status Report
  • [Presentation] NF-κB阻害剤DHMEQによるマウス形質細胞腫SP-2/0細胞のMMP-9およびMMP-13が関与する浸潤の抑制と抗がん剤感受性の増強2017

    • Author(s)
      Sidthipong Kulrawee、宇梶珠未、梅澤一夫
    • Organizer
      第21回がん分子標的治療学会2017.6.14-16
    • Related Report
      2017 Research-status Report
  • [Presentation] NF-κB阻害剤DHMEQによるTiO2ナノ粒子に誘導されるマクロファージ炎症反応の抑制2017

    • Author(s)
      宇梶珠未、深津仁見、及川佐枝子、出岡淑、市原佐保子、梅澤一夫、小出直樹
    • Organizer
      第64回トキシンシンポジウム (若手奨励講演)
    • Related Report
      2017 Research-status Report
  • [Presentation] Isolation of ketomycin from Streptomyces as an inhibitor of breast cancer cell migration and invasion2017

    • Author(s)
      Yinzhi Lin and Kazuo Umezawa
    • Organizer
      第76回日本癌学会
    • Related Report
      2017 Research-status Report
  • [Presentation] Molecular design of sugar-free migracin analog migracinal that inhibits cancer cell migration and invasion2017

    • Author(s)
      Tamami Ukaji, Yinzhi Lin, Naoki Koide, and Kazuo Umezawa
    • Organizer
      第76回日本癌学会
    • Related Report
      2017 Research-status Report
  • [Presentation] Inhibition of TiO2 nanoparticle-induced inflammatory reaction in macrophages by NF-κB inhibitor DHMEQ2017

    • Author(s)
      Kazuo Umezawa, Hitomi Fukatsu, Tamami Ukaji and Naoki Koide
    • Organizer
      13th Keio-Yonsei Joint Symposium(招待講演)(国際学会)
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research / Invited
  • [Remarks] 愛知医科大学ホームページ

    • Related Report
      2019 Annual Research Report
  • [Remarks] 梅澤ラボチャンネル

    • Related Report
      2019 Annual Research Report
  • [Remarks] 愛知医科大学ホームページ

    • Related Report
      2018 Research-status Report
  • [Remarks] 梅澤ラボ・チャンネル

    • Related Report
      2018 Research-status Report
  • [Remarks] 愛知医科大学ホームページ

    • Related Report
      2017 Research-status Report
  • [Remarks] 梅澤ラボ・チャンネル

    • Related Report
      2017 Research-status Report
  • [Patent(Industrial Property Rights)] 外用組成物の生産方法2018

    • Inventor(s)
      梅澤一夫、小出悠紀子
    • Industrial Property Rights Holder
      ブルネエズ株式会社
    • Industrial Property Rights Type
      特許
    • Filing Date
      2018
    • Acquisition Date
      2020
    • Related Report
      2019 Annual Research Report
  • [Patent(Industrial Property Rights)] マクロライド化合物の毒性のない抗炎症剤・抗転移剤としての新規用途2017

    • Inventor(s)
      梅澤一夫、林音知
    • Industrial Property Rights Holder
      愛知医科大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2017-193428
    • Filing Date
      2017
    • Related Report
      2017 Research-status Report

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Published: 2017-04-28   Modified: 2021-02-19  

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