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Effects of the syntax-related network dysfunction on language function

Research Project

Project/Area Number 17K01978
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Basic / Social brain science
Research InstitutionShowa University

Principal Investigator

KINNO Ryuta  昭和大学, 医学部, 講師 (70439397)

Project Period (FY) 2017-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Keywords統語処理 / fMRI / SBM / 脳内ネットワーク / 神経膠腫 / 言語 / 大脳皮質 / 皮質厚 / フラクタル次元 / 神経変性疾患 / 脳回構造 / 失語症 / MRI
Outline of Final Research Achievements

We examined the cerebral blood flows of patients with the nonfluent/agrammatic variant of primary progressive aphasia (naPPA) , and found that these patients showed the decreased CBF not only in the left frontal gyrus but also in the brain regions within the syntax-related networks. Moreover, we examined the relationships between cortical structure of patients with dementia and the linguistic memory function, and found that the preserved brain structure of the left insula cortex is important for the linguistic memory function. Furthermore, we examined the cortical structures of the patients with the left frontal glioma, and demonstrated that the global cortical structural changes among both hemispheres are occurred by a focal glioma.
These findings suggested that disfunction of the syntax-related networks causes the asyntactic comprehension.

Academic Significance and Societal Importance of the Research Achievements

本研究の成果は、神経変性疾患の患者では、統語構造の理解障害が、局所の障害ではなく、大脳ネットワーク全体の機能低下に起因することが分かった。また、左前頭葉の局所脳損傷で生じると思われていた統語処理の障害が、実は大脳全体の脳構造の変化によるものの可能性が示唆された。以上の結果は、局所の脳損傷が脳全体の機能的結合性のみならず、解剖学的結合性の変化も惹起し、その結果、統語構造の理解障害が生じることを示唆するものである。

Report

(5 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (43 results)

All 2020 2019 2018 2017

All Journal Article (19 results) (of which Peer Reviewed: 11 results,  Open Access: 9 results) Presentation (22 results) (of which Int'l Joint Research: 4 results,  Invited: 2 results) Book (2 results)

  • [Journal Article] Differential Effects of a Left Frontal Glioma on the Cortical Thickness and Complexity of Both Hemispheres2020

    • Author(s)
      Kinno Ryuta、Muragaki Yoshihiro、Maruyama Takashi、Tamura Manabu、Tanaka Kyohei、Ono Kenjiro、Sakai Kuniyoshi L
    • Journal Title

      Cerebral Cortex Communications

      Volume: 1 Issue: 1 Pages: 1-11

    • DOI

      10.1093/texcom/tgaa027

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Task-Induced Functional Connectivity of the Syntax-Related Networks for Patients with a Cortical Glioma2020

    • Author(s)
      Tanaka Kyohei、Kinno Ryuta、Muragaki Yoshihiro、Maruyama Takashi、Sakai Kuniyoshi L
    • Journal Title

      Cerebral Cortex Communications

      Volume: 1 Issue: 1 Pages: 1-15

    • DOI

      10.1093/texcom/tgaa061

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Increased Presence of Cerebral Microbleeds Correlates With Ventricular Enlargement and Increased White Matter Hyperintensities in Alzheimer’s Disease2020

    • Author(s)
      Kuroda Takeshi、Honma Motoyasu、Mori Yukiko、Futamura Akinori、Sugimoto Azusa、Yano Satoshi、Kinno Ryuta、Murakami Hidetomo、Ono Kenjiro
    • Journal Title

      Frontiers in Aging Neuroscience

      Volume: 12 Pages: 1-8

    • DOI

      10.3389/fnagi.2020.00013

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Nonsystemic vasculitic neuropathy in a patient with IgG-monoclonal gammopathy of undetermined significance2020

    • Author(s)
      Kinno Ryuta、Osakabe Yuyuko、Takahashi Seiya、Kurokawa Shinji、Owan Yoshiyuki、Ono Kenjiro、Baba Yasuhiko
    • Journal Title

      Medicine

      Volume: 99 Issue: 5 Pages: e19036-e19036

    • DOI

      10.1097/md.0000000000019036

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 言語機能障害2020

    • Author(s)
      金野 竜太、小野 賢二郎
    • Journal Title

      Clinical neuroscience

      Volume: 38 Pages: 211-213

    • Related Report
      2019 Research-status Report
  • [Journal Article] The Cerebellar Leptomeningeal Enhancement Associated with Cryptococcal Meningitis2019

    • Author(s)
      Shiromaru Azusa、Kinno Ryuta、Ito Naohito、Ono Kenjiro
    • Journal Title

      Internal Medicine

      Volume: 58 Issue: 1 Pages: 149-150

    • DOI

      10.2169/internalmedicine.1491-18

    • NAID

      130007542237

    • ISSN
      0918-2918, 1349-7235
    • Year and Date
      2019-01-01
    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] The relationship between thyroid function and cerebral blood flow in mild cognitive impairment and Alzheimer’s disease2019

    • Author(s)
      Nomoto Shohei、Kinno Ryuta、Ochiai Hirotaka、Kubota Satomi、Mori Yukiko、Futamura Akinori、Sugimoto Azusa、Kuroda Takeshi、Yano Satoshi、Murakami Hidetomo、Shirasawa Takako、Yoshimoto Takahiko、Minoura Akira、Kokaze Akatsuki、Ono Kenjiro
    • Journal Title

      PLOS ONE

      Volume: 14 Issue: 4 Pages: 0214676-0214676

    • DOI

      10.1371/journal.pone.0214676

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] High serum high-density lipoprotein-cholesterol is associated with memory function and gyrification of insular and frontal opercular cortex in an elderly memory-clinic population2019

    • Author(s)
      Kinno Ryuta、Mori Yukiko、Kubota Satomi、Nomoto Shohei、Futamura Akinori、Shiromaru Azusa、Kuroda Takeshi、Yano Satoshi、Ishigaki Seiichiro、Murakami Hidetomo、Baba Yasuhiko、Ono Kenjiro
    • Journal Title

      NeuroImage: Clinical

      Volume: 22 Pages: 101746-101746

    • DOI

      10.1016/j.nicl.2019.101746

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 特集 「左脳と右脳」の現在 前頭連合野における左右差-統辞処理関連の神経回路2018

    • Author(s)
      金野 竜太、酒井 邦嘉
    • Journal Title

      BRAIN and NERVE

      Volume: 70 Issue: 10 Pages: 1075-1085

    • DOI

      10.11477/mf.1416201139

    • ISSN
      1344-8129, 1881-6096
    • Year and Date
      2018-10-01
    • Related Report
      2018 Research-status Report
  • [Journal Article] Voxel-based lesion-symptom mapping2018

    • Author(s)
      金野 竜太
    • Journal Title

      Japanese Journal of Neuropsychology

      Volume: 34 Issue: 3 Pages: 209-217

    • DOI

      10.20584/neuropsychology.17039

    • NAID

      130007497827

    • ISSN
      0911-1085, 2189-9401
    • Year and Date
      2018-09-25
    • Related Report
      2018 Research-status Report
  • [Journal Article] 特集 もっとうまくいく! 病診連携の「伝え方」-わかりやすく伝えるための診療情報提供書作成のコツ 第Ⅱ章 <診療科別>コンサルトのポイント E.脳神経内科へコンサルト 3.記憶障害2018

    • Author(s)
      森 友紀子、金野 竜太
    • Journal Title

      内科

      Volume: 122 Issue: 3 Pages: 570-572

    • DOI

      10.15106/j_naika122_570

    • ISSN
      0022-1961, 2432-9452
    • Year and Date
      2018-09-01
    • Related Report
      2018 Research-status Report
  • [Journal Article] 特集 失語症の今 言語と脳機能2018

    • Author(s)
      金野 竜太
    • Journal Title

      総合リハビリテーション

      Volume: 46 Issue: 6 Pages: 505-510

    • DOI

      10.11477/mf.1552201326

    • ISSN
      0386-9822, 1882-1340
    • Year and Date
      2018-06-10
    • Related Report
      2018 Research-status Report
  • [Journal Article] 認知神経科学への手紙  言語学と脳科学、失語症学の歩み寄り2018

    • Author(s)
      金野 竜太
    • Journal Title

      Japanese Journal of Cognitive Neuroscience

      Volume: 20 Issue: 3+4 Pages: 182-183

    • DOI

      10.11253/ninchishinkeikagaku.20.182

    • NAID

      130007589616

    • ISSN
      1344-4298, 1884-510X
    • Related Report
      2018 Research-status Report
  • [Journal Article] 姿勢異常をきたす神経疾患(パーキンソニズム以外)の特徴.2018

    • Author(s)
      馬場 康彦、金野 竜太、小野 賢二郎
    • Journal Title

      神経内科

      Volume: 89 Pages: 408-412

    • Related Report
      2018 Research-status Report
  • [Journal Article] ニューロサイエンスの最新情報 小脳の言語機能2018

    • Author(s)
      7)金野竜太,酒井邦嘉
    • Journal Title

      Clinical Neuroscience

      Volume: 46 Pages: 622-623

    • Related Report
      2018 Research-status Report
  • [Journal Article] Agraphia of the left hand with dysfunction of the left superior parietal region without callosal lesions2018

    • Author(s)
      Kinno Ryuta、Ohashi Hideaki、Mori Yukiko、Shiromaru Azusa、Ono Kenjiro
    • Journal Title

      eNeurologicalSci

      Volume: 10 Pages: 16-18

    • DOI

      10.1016/j.ensci.2018.01.005

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of word order and morphological information on Japanese sentence comprehension in nonfluent/agrammatic variant of primary progressive aphasia2017

    • Author(s)
      Kinno Ryuta、Kii Yoshitaka、Kurokawa Shinji、Owan Yoshiyuki、Kasai Hideyo、Ono Kenjiro
    • Journal Title

      Journal of Neurolinguistics

      Volume: 44 Pages: 107-119

    • DOI

      10.1016/j.jneuroling.2017.03.006

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Differential Effects of the Factor Structure of the Wechsler Memory Scale-Revised on the Cortical Thickness and Complexity of Patients Aged Over 75 Years in a Memory Clinic Setting2017

    • Author(s)
      Kinno Ryuta、Shiromaru Azusa、Mori Yukiko、Futamura Akinori、Kuroda Takeshi、Yano Satoshi、Murakami Hidetomo、Ono Kenjiro
    • Journal Title

      Frontiers in Aging Neuroscience

      Volume: 9 Pages: 1-12

    • DOI

      10.3389/fnagi.2017.00405

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Activation changes of the left inferior frontal gyrus for the factors of construction and scrambling in a sentence2017

    • Author(s)
      TANAKA Kyohei、OHTA Shinri、KINNO Ryuta、SAKAI Kuniyoshi L.
    • Journal Title

      Proceedings of the Japan Academy, Series B

      Volume: 93 Issue: 7 Pages: 511-522

    • DOI

      10.2183/pjab.93.031

    • NAID

      130005881857

    • ISSN
      0386-2208, 1349-2896
    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] アルツハイマー病における脳小血管病と脳脊髄液循環障害の関連について2019

    • Author(s)
      黒田 岳志, 小菅 将太, 小口 達敬, 森 友紀子, 二村 明徳, 杉本 あずさ, 矢野 怜, 金野 竜太, 村上 秀友, 小野 賢二郎
    • Organizer
      第60回日本神経学会学術大会
    • Related Report
      2019 Research-status Report
  • [Presentation] Effects of vitamin B12 on memory function in elderly patients2019

    • Author(s)
      木村 篤史, 金野 竜太, 二村 明徳, 野元 祥平, 久保田 怜美, 森 友紀子, 杉本 あずさ, 黒田 岳志, 矢野 怜;, 村上 秀友, 小野 賢二郎
    • Organizer
      第60回日本神経学会学術大会
    • Related Report
      2019 Research-status Report
  • [Presentation] Hemoglobin and hematocrit levels are sensitive to functional imaging abnormalities in patients with memory loss2019

    • Author(s)
      Satoshi Yano, Yukiko Mori, Akinori Futamura, Azusa Sugimoto, Takeshi Kuroda, Ryuta Kinno, Kenjiro Ono
    • Organizer
      Alzheimer’s Association International Conference 2019
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] アルツハイマー型認知症、軽度認知障害における甲状腺機能と脳血流量の関連の検討2019

    • Author(s)
      野元 祥平,金野 竜太,森 友紀子,二村 明徳,杉本 あすざ,黒田 岳志,矢野 怜,村上 秀友,落合 裕隆,小風 暁,小野 賢二郎
    • Organizer
      第38回認知症学会学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] fMRI による言語機能マッピング2019

    • Author(s)
      金野竜太
    • Organizer
      第21回日本ヒト脳機能マッピング学会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] IgG型M蛋白血症と感覚性失調性軸索型ニューロパチーを伴った非全身性血管炎ニューロパチーの56歳女性例2019

    • Author(s)
      刑部祐友子、高橋聖也、黒川信二、大湾喜行、金野竜太、小野賢二郎、馬場康彦
    • Organizer
      第228回 日本神経学会関東・甲信越地方会
    • Related Report
      2018 Research-status Report
  • [Presentation] Effects of a left frontal glioma on the cortical structures of both hemispheres2018

    • Author(s)
      Ryuta Kinno, Yoshihiro Muragaki, Takashi Maruyama, Manabu Tamura, Kyohei Tanaka, Kenjiro Ono, Kuniyoshi L. Sakai
    • Organizer
      The 41st Annual Meeting of the Japan Neuroscience Society
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] The reproducibility and variety of the three syntax-related networks for sentence processing2018

    • Author(s)
      Kyohei Tanaka, Ryuta Kinno, Kuniyoshi L. Sakai
    • Organizer
      The 41st Annual Meeting of the Japan Neuroscience Society
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Effect of factor structure of the Wechsler Memory Scale-Revised on cortical structure for elderly patients2018

    • Author(s)
      Ryuta Kinno, Azusa Shiromaru, Yukiko Mori, Akinori Futamura, Takeshi Kuroda, Satoshi Yano, Hidetomo Murakami, Kenjiro Ono
    • Organizer
      第59回日本神経学会学術大会
    • Related Report
      2018 Research-status Report
  • [Presentation] Effects of vitamin B12 on memory function and complexity of the cortical structure2018

    • Author(s)
      Atushi Kimura, Ryuta Kinno, Azusa Shiromaru, Yukiko Mori, Akinori Futamura, Takeshi Kuroda, Satoshi Yano, Hidetomo Murakami, Kenjiro Ono
    • Organizer
      第59回日本神経学会学術大会
    • Related Report
      2018 Research-status Report
  • [Presentation] 右脳静脈洞塞栓症後に顔の中心部が大きく見えるようになった相貌変形視症例の検討2018

    • Author(s)
      二村 明徳, 小山 慎一, 大橋 英朗, 三木 綾子, 小口 達敬, 金野 竜太, 村上 秀友, 小野 賢二郎
    • Organizer
      第42回日本神経心理学会学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] 後期高齢者における高HDL血症は視覚性記憶機能と島皮質の脳回構造の維持に関連する2018

    • Author(s)
      金野竜太、森友紀子、刑部祐友子、高橋聖也、野元祥平、黒川信二、大湾喜行、石垣征一郎、馬場康彦、小野賢二郎
    • Organizer
      第37回認知症学会学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] 小脳に限局した髄膜造影効果を呈しCryptococcus neoformans髄膜脳炎と診断した71歳男性例2018

    • Author(s)
      小菅将太, 井藤尚仁, 野原哲人, 森友紀子, 二村明徳, 四郎丸あずさ, 金野竜太, 村上秀友, 小野賢二郎
    • Organizer
      第23回日本神経感染症学会総会・学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] ADとDLBの鑑別におけるECD-脳血流SPECT CIS coreの有用性について2018

    • Author(s)
      二村 明徳, 四郎丸 あずさ, 森 友紀子, 黒田 岳志, 矢野 怜, 金野 竜太, 村上 秀友, 小野 賢二郎
    • Organizer
      第37回認知症学会学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] 老年期うつ病評価尺度(GDS)を用いた初期パーキンソン病におけるうつと運動症状の検討2018

    • Author(s)
      石垣 征一郎, 内山 正信, 井藤 尚仁, 金野 竜太, 村上 秀友, 馬場 康彦, 小野 賢二郎
    • Organizer
      第37回認知症学会学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] MRI構造・機能画像を駆使した脳腫瘍術前手術シミュレーション2018

    • Author(s)
      田村学, 丸山隆志, 新田雅之, 田村学, 丸山隆志, 新田雅之, 齋藤太一, 正宗賢, 伊関洋, 金野竜太, 酒井邦嘉, 川俣貴一, 村垣善浩, 村垣善浩
    • Organizer
      第23回日本脳腫瘍の外科学会
    • Related Report
      2018 Research-status Report
  • [Presentation] 心筋梗塞後に進行性の下肢脱力を認めた43歳男性例2018

    • Author(s)
      高橋聖也、刑部祐友子、黒川信二、大湾喜行、金野竜太、馬場康彦、小野賢二郎
    • Organizer
      第227回 日本神経学会関東・甲信越地方会
    • Related Report
      2018 Research-status Report
  • [Presentation] 左前頭葉の脳腫瘍が大脳皮質厚に及ぼす影響2018

    • Author(s)
      金野 竜太,村垣 善浩,丸山 隆志,田村 学,田中 恭平,小野 賢二郎,酒井 邦嘉
    • Organizer
      第20回ヒト脳機能マッピング学会
    • Related Report
      2017 Research-status Report
  • [Presentation] 左手の失書を呈した脳梁病変を伴わない左頭頂葉上部病変例2017

    • Author(s)
      金野竜太、大橋英朗、森友紀子、四郎丸あずさ、小野賢二郎
    • Organizer
      第41回日本高次脳機能障害学会学術総会
    • Related Report
      2017 Research-status Report
  • [Presentation] もの忘れ外来を受診した75歳以上の高齢者におけるWMS-Rの因子構造と神経画像的特徴2017

    • Author(s)
      金野竜太、森友紀子、二村明憲、四郎丸あずさ、黒田岳志、矢野怜、村上秀友、小野賢二郎
    • Organizer
      第36回認知症学会学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] GYRIFICATION IN THE LEFT PRECUNEUS IS POSITIVELY CORRELATED WITH THE ATTENTION INDEX OF THE WECHSLER MEMORY SCALE-REVISED IN ELDERLY PATIENTS WITH MEMORY LOSS2017

    • Author(s)
      Ryuta Kinno, Akinori Futamura, Azusa Shiromaru-Sugimoto, Takeshi Kuroda, Satoshi Yano, Hidetomo Murakami, Kenjiro Ono
    • Organizer
      XXIII World congress of Neurology
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Voxel Based lesion symptom mapping2017

    • Author(s)
      金野 竜太
    • Organizer
      第41回日本神経心理学会学術集会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Book] ブレインサイエンスレビュー 神経膠腫が大脳皮質に及ぼす機能的・構造的影響2020

    • Author(s)
      金野 竜太
    • Total Pages
      24
    • Publisher
      ブレインサイエンス振興財団
    • ISBN
      9784878051647
    • Related Report
      2019 Research-status Report
  • [Book] レビー小体型認知症診療ハンドブック 6 症状から見たレビー小体型認知症 1)認知機能障害2019

    • Author(s)
      久保田 怜美、金野 竜太、小野 賢二郎
    • Total Pages
      3
    • Publisher
      フジメディカル出版
    • ISBN
      9784862701756
    • Related Report
      2019 Research-status Report

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Published: 2017-04-28   Modified: 2022-01-27  

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