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The functional role of perivascular scavenger cells in the maintenance of brain homeostasis

Research Project

Project/Area Number 17K01983
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Basic / Social brain science
Research InstitutionNational Center of Neurology and Psychiatry

Principal Investigator

Matsuno Hitomi  国立研究開発法人国立精神・神経医療研究センター, 神経研究所 疾病研究第三部, リサーチフェロー (40415302)

Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2019: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2018: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywordsマクロファージ / ミクログリア / 血管脳関門 / うつ病 / ストレス / 脳内炎症 / 神経―血管―グリアユニット / 脳血管関門 / 神経科学
Outline of Final Research Achievements

In the central nervous system, resident macrophages play important roles for immune responses against inflammation, and brain repair mechanism. We performed in vivo imaging of cerebro-vascular structures, and identified brain perivascular macrophages (PVMs). We found that dye-labeled PVM is difference cell type from microglia, and PVMs were apposed to blood vessel walls in both brain surface and deeper brain layers. They actively uptook fluorescence dyes, and persistently accumulated dyes in the granular structures of the cytoplasm. To characterize the functional roles of PVMs in the pathological condition, we investigated the dynamics of PVM in the stress-induced mouse depression model. Chronic restraint stress induced abnormal increase of vascular permeability as well as decline in the number of CD163-positive PVM. These results suggest that PVM may play principle functions for the clearance of waste materials in the perivascular spaces to maintain homeostasis balance.

Academic Significance and Societal Importance of the Research Achievements

本研究では脳常在マクロファージの一つであるPVMについて、うつ病モデルマウスにおける動態変化を解析した。その結果、慢性ストレスはPVMの機能低下を引き起こすことが示唆された。本研究で得られた結果はうつ病だけでなく血管障害を伴う脳疾患の新規治療法やバイオマーカー開発につながることが期待される。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (3 results)

All 2020 2019 2018

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (2 results)

  • [Journal Article] Comparison of physiological and behavioral responses to chronic restraint stress between C57BL/6J and BALB/c mice2020

    • Author(s)
      Tsuchimine Shoko、Matsuno Hitomi、O’Hashi Kazunori、Chiba Shuichi、Yoshimura Aya、Kunugi Hiroshi、Sohya Kazuhiro
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 525 Issue: 1 Pages: 33

    • DOI

      10.1016/j.bbrc.2020.02.073

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Comparisons between C57BL6/J and BALB/c mice in behavioral test and physiological change after chronic restraint stress.2019

    • Author(s)
      Tsuchimine S, Matsuno H, Ohashi K, Chiba S, Yoshimura A, Nakajima S, Ishiwata S, Ogawa S, Sohya K, Kunugi H
    • Organizer
      第42回日本神経科学大会 (Neuro2019).
    • Related Report
      2019 Annual Research Report
  • [Presentation] A role of brain macrophages to constitute Blood-brain barrier ー 血液脳関門におけるマクロファージの役割ー2018

    • Author(s)
      Kazunori O’Hashi, Hitomi Matsuno, Shoko Tsuchimine, Shuich Chiba, Kazuhiro Sohya and Hiroshi Kunugi
    • Organizer
      第41回日本神経科学大会
    • Related Report
      2018 Research-status Report

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Published: 2017-04-28   Modified: 2021-02-19  

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