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Encoding mechanism of spatial information in the primate entorhinal-hippocampal system.

Research Project

Project/Area Number 17K01991
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Brain biometrics
Research InstitutionUniversity of Toyama

Principal Investigator

Tamura Ryoi  富山大学, 学術研究部医学系, 教授 (60227296)

Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords内嗅皮質 / 霊長類 / 空間情報処理 / ニューロン活動 / 海馬 / 記憶 / 周期性徐波 / ニホンザル / サル / グリッド細胞 / 場所応答 / 睡眠 / entorhinal cortex / hippocampus / primates / encoding / spatial information
Outline of Final Research Achievements

To clarify neural mechanism of information encoding in the primate hippocampo-entorhinal system, neuronal activity was recorded from the entorhinal cortex and its related brain areas in monkeys while the animal performed shuttling behavior on a linear track. Of the 348 neurons recorded in the entorhinal cortex and related areas, 15 showed spatially tuned activity, but none of these neurons exhibited clear gridness. Twenty one neurons showed rhythmic firing in the slow wave band, all of which were within the delta band (< 4 Hz); none of these neurons exhibited significant slow rhythmic firing in the theta band (5-10 Hz). These results indicate that the primate entorhinal cortex and related areas do encode spatial information in a different manner than the rodent entorhinal system where clear gridness and slow wave activity in the theta band appear in the activity of neurons in this system.

Academic Significance and Societal Importance of the Research Achievements

げっ歯類を用いた多くの研究より,海馬-内嗅皮質系には場所細胞やグリッド細胞が存在し,その細胞集団がシータ波帯域の周期性活動を行なうことが,空間認知に重要な役割を果たしている考えられてきた.本研究の学術的意義は,霊長類の内嗅皮質系でも空間情報処理は行なわれているが、グリッド性やシータ波帯域の周期性活動などげっ歯類の研究で得られてきた知見がヒトを含め、霊長類には見られないことを明らかにした点である。また、本研究の社会的意義は,当該学問分野の研究者に重要な示唆を与えるばかりでなく,認知科学,精神医学,人工知能,計算論的神経科学等の学問領域に対する波及効果もあることである.

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (21 results)

All 2019 2018 2017 Other

All Journal Article (7 results) (of which Peer Reviewed: 7 results,  Open Access: 3 results) Presentation (12 results) (of which Int'l Joint Research: 2 results) Remarks (2 results)

  • [Journal Article] Data on the activity of place cells in the hippocampal CA1 subfield of a monkey performing a shuttling task.2019

    • Author(s)
      Hazama Y, Tamura R
    • Journal Title

      Data in Brief

      Volume: 26 Pages: 104467-104467

    • DOI

      10.1016/j.dib.2019.104467

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Horizontal saccadic velocity in patients with exotropia before and after unilateral resection and recession surgery. Journal of Ophthalmology.2019

    • Author(s)
      Mihara M, Hayashi A, Fujita K, Kakeue K, Tamura R
    • Journal Title

      J Ophthalmol

      Volume: 2019 Pages: 1-6

    • DOI

      10.1155/2019/1374917

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of self-locomotion on the activity of place cells in the hippocampus of a freely behaving monkey.2019

    • Author(s)
      Hazama Y, Tamura R
    • Journal Title

      Neurosci Lett

      Volume: 701 Pages: 32-37

    • DOI

      10.1016/j.neulet.2019.02.009

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] The combined efficacy of OTS964 and temozolomide for reducing the size of power-law coded heterogeneous glioma stem cell populations.2019

    • Author(s)
      Sugimori M, Hayakawa Y, Tamura R, Kuroda S
    • Journal Title

      Oncotarget

      Volume: 10 Issue: 24 Pages: 2397-2415

    • DOI

      10.18632/oncotarget.26800

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Crucial information for efficient face searching by humans and Japanese macaques.2018

    • Author(s)
      Nakata R, Eifuku S, Tamura R
    • Journal Title

      Anim Cogn

      Volume: 21 Issue: 1 Pages: 155-164

    • DOI

      10.1007/s10071-017-1148-9

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Fixation stability of the upward gaze in patients with myasthenia gravis: an eye-tracker study.2017

    • Author(s)
      Mihara M, Hayashi A, Fujita K, Kakeue K, Tamura R
    • Journal Title

      BMJ Open ophth

      Volume: 2 Issue: 1 Pages: e000072-e000072

    • DOI

      10.1136/bmjophth-2017-000072

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Targeting the T-Lak cell originated protein kinase by OTS964 shrinks the size of power-law coded heterogeneous glioma stem cell populations.2017

    • Author(s)
      4) Sugimori M, Hayakawa Y, Koh M, Hayashi T, TamuraR, Kuroda S
    • Journal Title

      Oncotarget

      Volume: 9 Issue: 3 Pages: 3043-3059

    • DOI

      10.18632/oncotarget.23077

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Presentation] サルの海馬神経活動を記録するためのデータロガーの開発.2019

    • Author(s)
      田村了以,浅野昂志
    • Organizer
      第66回中部日本生理学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Effects of self-motion on the hippocampal CA1 place cell activities in the freely behaving monkey.2019

    • Author(s)
      Hazama Y, Asano T, Tamura R
    • Organizer
      19th FAOPS Congress (FAOPS 2019)
    • Related Report
      2018 Research-status Report
  • [Presentation] Horizontal saccadic velocity in patients with exotropia before and after strabismus surgery.2018

    • Author(s)
      Mihara M, Fujita K, Hayashi A, Kakeue K, Tamura R
    • Organizer
      13th Meeting of International Strabismus Association Joint meeting with AAPOS
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] 自由行動下のサル海馬場所細胞.2018

    • Author(s)
      間 祐太朗,田村了以
    • Organizer
      第95回日本生理学会大会
    • Related Report
      2018 Research-status Report
  • [Presentation] 水平斜視患者の水平サッケード速度.2018

    • Author(s)
      三原美晴,藤田和也,掛上 謙,林 篤志,田村了以
    • Organizer
      第122回日本眼科学会総会
    • Related Report
      2018 Research-status Report
  • [Presentation] 斜視手術が外斜視患者の水平追従性滑動性眼球運動に及ぼす変化.2018

    • Author(s)
      三原美晴,掛上 謙,林 篤志,田村了以
    • Organizer
      第74回日本弱視斜視学会総会
    • Related Report
      2018 Research-status Report
  • [Presentation] Spatial representation and firing periodicity of hippocampal CA1 pyramidal neurons in the freely behaving monkey.2017

    • Author(s)
      Hazama Y, Tamura R
    • Organizer
      SFN2017 47th annual meeting of Society for Neuroscinece
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 自由行動下におけるサル海馬ニューロンの場所応答性.2017

    • Author(s)
      間 祐太朗,田村了以
    • Organizer
      第94回日本生理学会大会
    • Related Report
      2017 Research-status Report
  • [Presentation] 自由行動下におけるサル海馬ニューロンの発火周期特性.2017

    • Author(s)
      間 祐太朗,田村了以
    • Organizer
      第40回日本神経科学大会
    • Related Report
      2017 Research-status Report
  • [Presentation] 自由行動下サル海馬ニューロンの場所応答性.2017

    • Author(s)
      間 祐太朗,田村了以
    • Organizer
      第26回海馬と高次脳機能学会
    • Related Report
      2017 Research-status Report
  • [Presentation] 自由行動下サルにおける海馬錐体細胞の場所応答性.2017

    • Author(s)
      間 祐太朗,田村了以
    • Organizer
      第64回中部日本生理学会
    • Related Report
      2017 Research-status Report
  • [Presentation] 簡易型心電図テレメトリの自作と性能評価.2017

    • Author(s)
      住田 爽,間 祐太朗,田村了以
    • Organizer
      第64回中部日本生理学会
    • Related Report
      2017 Research-status Report
  • [Remarks] 富山大学医学部・統合神経科学講座

    • URL

      http://www.med.u-toyama.ac.jp/ins/index-j.html

    • Related Report
      2019 Annual Research Report
  • [Remarks] 富山大学医学部 統合神経科学(生理学)講座

    • URL

      http://www.med.u-toyama.ac.jp/ins/index-j.html

    • Related Report
      2018 Research-status Report 2017 Research-status Report

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Published: 2017-04-28   Modified: 2021-02-19  

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