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An attempt to make a dynamic functional brain map

Research Project

Project/Area Number 17K01993
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Brain biometrics
Research InstitutionTohoku Fukushi University

Principal Investigator

Sung Yul-Wan  東北福祉大学, 感性福祉研究所, 准教授 (30358816)

Co-Investigator(Kenkyū-buntansha) 小川 誠二  東北福祉大学, 感性福祉研究所, 教授 (00358813)
河地 庸介  東北福祉大学, 総合福祉学部, 准教授 (20565775)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords脳機能計測 / 非侵襲的脳活動計測 / 動的脳機能マップ / 安静時fMRI / BOLD / 信号経路 / resting state fMRI / 動特性 / 神経活動 / 非線形 / 超高速測定 / 超高速MRI / 脳機能 / 機能マップ / 高感度
Outline of Final Research Achievements

An attempt was made in this study to create a dynamic functional brain map related to brain activities. In fMRI experiments with checker pattern stimulation at 20 Hz for inducing such rapid neural activity, the latencies of the signals were in the order of thalamus, visual cortex, insular cortex. We futher tried to make a dynamic functional brain map through resting fMRI signals because resting state fMRI was a method that could get stable signals for the map. For the purpose, it was made sure that the resting fMRI signals reflected the BOLD effect by showing a linear change of multi-echo fMRI signals with respect to the echo-time in many brain regions. By analyzing the resting fMRI signals in the whole brain, we could identify 96 brain regions related to visual, auditory, emotion, memory, attention, taste, and language. Then we could create a dynamic functional brain map based on the latency patterns from the primary sensory cortices to the higher cortices.

Academic Significance and Societal Importance of the Research Achievements

脳の各部位または部位間の動的な活動に対する情報を得ることは、脳の働きを理解する上で必須不可欠である。本研究では静的脳機能マップの情報の上に動特性マップを加えることができた。これにより、脳内の信号の伝達過程、信号の入出力関係に関わる情報が加えられることになり、第一感覚野からの情報が如何に処理されるかについての信号処理メカニズムの解明など脳機能研究に貢献できる。また、学習、訓練などによる脳の可塑的変化及び加齢などによる脳認知機能変化などをダイナミックな観点でとらえることが期待でき、脳計測による教育効果の評価と認知症の早期診断などのような応用技術の開発に貢献できると考えられる。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (15 results)

All 2020 2019 2018 Other

All Int'l Joint Research (1 results) Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (10 results) (of which Int'l Joint Research: 5 results)

  • [Int'l Joint Research] Neuroscience Research Institute/Gachon University(韓国)

    • Related Report
      2017 Research-status Report
  • [Journal Article] Evaluating the effects of head motion when processing multi-echo MRI data2020

    • Author(s)
      1.Sung Y, Kawachi Y, Ogawa S
    • Journal Title

      Report of Kansei Fukushi Research Institute

      Volume: -

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Spatial and temporal distribution of category-specific brain areas seen through resting state fMRI signals2020

    • Author(s)
      2.Sung Y, Naoe T, Kiyama S, Ogawa S
    • Journal Title

      Report of Kansei Fukushi Research Institute

      Volume: -

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of Multichannel Head Array Coils for fMRI Experiments.2019

    • Author(s)
      Sung Y, Kawachi Y, Ogawa S
    • Journal Title

      Report of Kansei Fukushi Research Institute

      Volume: -

    • NAID

      40021937257

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Estimation of physiological sources of nonlinearity in blood oxygenation level-dependent contrast signals2018

    • Author(s)
      Kang Daehun、Sung Yul-Wan、Shioiri Satoshi
    • Journal Title

      Magnetic Resonance Imaging

      Volume: 46 Pages: 121-129

    • DOI

      10.1016/j.mri.2017.10.017

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Presentation] Functional characteristics of category-specific brain areas seen through rs-fMRI signals2019

    • Author(s)
      5.Naoe T, Sung Y, Kiyama S, Ogawa S
    • Organizer
      ISMRM Japan Chapter, Dec13-14 (Ciba, QST)
    • Related Report
      2019 Annual Research Report
  • [Presentation] Functional characteristics of stimulus driven resting state fMRI signals2019

    • Author(s)
      3.Sung Y, Ogawa S
    • Organizer
      The 46th annual meeting of the Society for Neuroscience, Chicago(Convention Center), USA, Oct. 19 -23
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Evaluation of intrinsic properties in resting state fMRI signals by multi-echo EPI2019

    • Author(s)
      4.Sung Y, Ogawa S
    • Organizer
      The 47th annual meeting of the Japanese Society for Magnetic Resonance In Medicine, Kumamoto, Dec13-14 (JAL Hotel)
    • Related Report
      2019 Annual Research Report
  • [Presentation] Difference in functional characteristics of task-fMRI and resting state fMRI2019

    • Author(s)
      6.Sung Y, Ogawa S
    • Organizer
      The 25th annual meeting of the Organization for Human Brain Mapping, Rome (Auditorium), Italy, Jun 9-13
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Task related regional difference in temporal characteristics of fMRI signals2019

    • Author(s)
      7.Sung Y, Ogawa S
    • Organizer
      The 25th annual meeting of the Organization for Human Brain Mapping, Rome (Auditorium), Italy, Jun 9-13
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Estimation of specific functional brain areas reflecting individual characteristics2019

    • Author(s)
      Sung Y, Kawachi Y, Ogawa S
    • Organizer
      The 21st Congress of Japan Human Brain Mapping Society, Tokyo (The University of Tokyo), Mar 15-16
    • Related Report
      2018 Research-status Report
  • [Presentation] Quantification method of brain networks and estimation of network measure2019

    • Author(s)
      Kikuchi Y, Sung Y, Ogawa S
    • Organizer
      The 21st Congress of Japan Human Brain Mapping Society, Tokyo (The University of Tokyo), Mar 15-16
    • Related Report
      2018 Research-status Report
  • [Presentation] Functional specificity of resting-state fMRI signals2018

    • Author(s)
      Sung Y, Kawachi Y, Ogawa S
    • Organizer
      The 23th annual meeting of the Organization for Human Brain Mapping, Singapore (SunTech Place), Jun 17-21
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Functional specificity of resting-state fMRI signals2018

    • Author(s)
      Sung Y, Ogawa S
    • Organizer
      The 46th annual meeting of the Japanese Society for Magnetic Resonance In Medicine, Kanazawa (Hotel Nikko Kanazawa), Sep 18-20
    • Related Report
      2018 Research-status Report
  • [Presentation] High resolution functional imaging of motor/somatosensory cortices by 7T2018

    • Author(s)
      Whang Seok-Il, Sung Yul-Wan, Chung Junyooung, Ogawa Seiji
    • Organizer
      International Congress on Magnetic Resonance Imaging (ICMRM) 2018, Seoul (Grand Hilton Hotel), Korea
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research

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Published: 2017-04-28   Modified: 2022-02-22  

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