| Project/Area Number |
17K01994
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Brain biometrics
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| Research Institution | Kindai University |
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Principal Investigator |
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2017: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 時間認知 / 時間再生 / 神経細胞活動 / 前頭連合野 / 時間知覚 / 運動前野 / 大脳基底核 / 認知科学 / 時間計測 / 大脳皮質 |
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| Outline of Final Research Achievements |
Interval timing is vitally important in sensory perception and motor control. In the research on interval timing, it has not been clarified whether duration perception and interval generation share a common neuronal mechanism. To investigate the possible shared neuronal mechanism, neuronal activity was recorded from monkey prefrontal cortex (PFC) during the task in which subjects estimated durations of a visual stimulus and produced intervals indicated by the duration of the visual stimulus in motor preparation. A group of PFC neurons exhibited timing-related activity during the stimulus presentation period when the subjects measured and judged stimulus duration. Another group of neurons showed build-up activity during the movement retention period when the subjects produced an interval for the movement start. These results suggest that different neuronal mechanisms might work for the duration perception of visual stimulus and for the interval generation in motor preparation in PFC.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究成果は、まず、時間情報の脳内処理機構の解明に寄与する。時間情報処理機構は、未だ神経科学分野の教科書にも明示的に記載されておらず、極めて有意義な知見である。さらに、薬物投与などにより主観的な時間を操作し、そのときの課題関連活動の変化を調べることで、主観的な時間を生成する神経機構の解明へと発展させることができる。また、注意欠陥多動障害や統合失調症など、時間情報処理の異常が行動障害の基盤をなす、と考えられている精神神経疾患のシステム脳科学的な病態解明に役立つ。
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