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Supply control of reactive oxygen species in the liquid depth direction by plasma irradiation

Research Project

Project/Area Number 17K05100
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Plasma electronics
Research InstitutionNishinippon Institute of Technology (2018-2019)
Nippon Bunri University (2017)

Principal Investigator

Kawasaki Toshiyuki  西日本工業大学, 工学部, 教授 (30352404)

Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2017: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Keywords大気圧非熱平衡プラズマ / プラズマジェット / プラズマ医療 / 活性酸素 / 可視化 / 化学プローブ法 / 気液界面 / 化学プローブ / プラズマ誘起流 / 活性酸素輸送 / 活性酸素分布 / PIV計測 / プラズマ農業 / ゲル状試薬 / 二次元可視化
Outline of Final Research Achievements

In the cases of plasma-biomedical applications, targets usually include a large amount of liquid. The chemical interaction between plasma and liquids have to be understood for safe and effective use of plasma technology. However, the mechanisms for chemical reactions in the liquid targets induced by plasma irradiation is currently unavailable in detail. Therefore, we have studied the chemical reactions in a tissue model using our original method. The method can visualize two-dimensional distribution of oxidation reactions even in a tissue model. As a result, we clarified the relationship between plasma irradiation conditions and the oxidation reactions in a tissue model. We indicated that the distributions of the oxidation reactions can be controlled by plasma irradiation conditions.

Academic Significance and Societal Importance of the Research Achievements

本研究は,プラズマを生体に直接照射してがん・創傷治療に利用しようとする分野である。生体に照射して副作用なく良い効果だけを獲得するためには,関連するメカニズムをすべて解明する必要がある。特に本研究はプラズマ照射が生体内部に誘起する化学反応メカニズムを解明しようとする研究である。これはプラズマ技術を安全かつ効果的に活用するために必要不可欠な課題の1つである。得られた成果は本技術の更なる発展につながる。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (40 results)

All 2020 2019 2018 2017 Other

All Journal Article (8 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 7 results,  Open Access: 3 results) Presentation (29 results) (of which Int'l Joint Research: 17 results,  Invited: 4 results) Book (1 results) Remarks (2 results)

  • [Journal Article] Effects of surrounding gas on plasma-induced downward liquid flow2020

    • Author(s)
      Kawasaki Toshiyuki、Nishida Keisuke、Uchida Giichiro、Mitsugi Fumiaki、Takenaka Kosuke、Koga Kazunori、Setsuhara Yuichi、Shiratani Masaharu
    • Journal Title

      Japanese Journal of Applied Physics

      Volume: 59 Issue: SH Pages: SHHF02-SHHF02

    • DOI

      10.35848/1347-4065/ab71dc

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Local supply of reactive oxygen species into a tissue model by atmospheric-pressure plasma-jet exposure2019

    • Author(s)
      Kawasaki Toshiyuki、Mitsugi Fumiaki、Koga Kazunori、Shiratani Masaharu
    • Journal Title

      Journal of Applied Physics

      Volume: 125 Issue: 21 Pages: 213303-213303

    • DOI

      10.1063/1.5091740

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Measurement of OH radicals distribution in a microwave plasma sheet using LIF method2019

    • Author(s)
      Tanski Mateusz、Kocik Marek、Hrycak Bartosz、Czylkowski Dariusz、Jasinski Mariusz、Kawasaki Toshiyuki、Kanazawa Seiji
    • Journal Title

      Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy

      Volume: 222 Pages: 117268-117268

    • DOI

      10.1016/j.saa.2019.117268

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Visualization of ROS Distribution Generated by Atmospheric Plasma Jet2019

    • Author(s)
      F. Mitsugi, S. Kusumegi, and T. Kawasaki
    • Journal Title

      IEEE Transactions on Plasma Science

      Volume: 47 Issue: 2 Pages: 1057-1062

    • DOI

      10.1109/tps.2018.2858807

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Distribution of Pressure Wave Generated by Atmospheric Plasma Jet Measured With Optical Wave Microphone2019

    • Author(s)
      F. Mitsugi, S. Kusumegi, T. Nakamiya, Y. Sonoda, and T. Kawasaki
    • Journal Title

      IEEE Transactions on Plasma Science

      Volume: 47 Issue: 2 Pages: 1063-1070

    • DOI

      10.1109/tps.2018.2866261

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] 大気圧非平衡Heプラズマジェットと溶液との相互作用に関する可視化研究2019

    • Author(s)
      内田儀一郎, 竹中弘祐, 川崎敏之, 古閑一憲, 白谷正治, 節原裕一
    • Journal Title

      スマートプロセス学会誌

      Volume: 8 Pages: 58-63

    • NAID

      130007821490

    • Related Report
      2018 Research-status Report
  • [Journal Article] Transportation of reactive oxygen species in a tissue phantom after plasma irradiation2018

    • Author(s)
      Toshiyuki Kawasaki, Gouya Kuroeda, Ryuhei Sei, Masaaki Yamaguchi, Reishi Yoshinaga, Riho Yamashita, Hikaru Tasaki, Kazunori Koga, and Masaharu Shiratani
    • Journal Title

      Japanese Journal of Applied Physics

      Volume: 57 Issue: 1S Pages: 01AG01-01AG01

    • DOI

      10.7567/jjap.57.01ag01

    • NAID

      210000148568

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 液体が関与するプラズマ研究へのKI‐デンプン水溶液の応用2017

    • Author(s)
      川崎敏之
    • Journal Title

      プラズマ・核融合学会誌

      Volume: 93 Pages: 240-245

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Relationship between plasma irradiation conditions and induced liquid flows2019

    • Author(s)
      Toshiyuki Kawasaki, Nishida Keisuke, and Fumiaki Mitsugi
    • Organizer
      The 11th Asia-Pacific International Symposium on the Basics and Applications of Plasma Technology (APSPT-11)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Local ROS supply in a tissue model by plasma direct irradiation2019

    • Author(s)
      Toshiyuki Kawasaki
    • Organizer
      The 7th East Asia Joint Symposium on Plasma and Electrostatics Technologies for Environmental Applications (EAPETEA-7)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 2-D Distribution of ROS Supplied into a Tissue Model by Atmospheric-pressure Plasma Irradiation2019

    • Author(s)
      Toshiyuki Kawasaki
    • Organizer
      4th ISNPEDADM 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Visualization and control of 2-D ROS distribution in liquid matter irradiated with an atmospheric-pressure plasma-jet2019

    • Author(s)
      T. Kawasaki, G. Uchida, K. Koga, and M. Shiratani
    • Organizer
      12th Asian-European International Conference on Plasma Surface Engineering (AEPSE2019)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Effects of surrounding gas on plasma-induced liquid flow2019

    • Author(s)
      T. Kawasaki, K. Nishida, M. Kawaguchi, Y. Hazama, G. Uchida, F. Mitsugi, N. Takeuchi, K. Takenaka, K. Koga, Y. Setsuhara, M. Shiratani
    • Organizer
      XXXIV International Conference on Phenomena in Ionized Gases (XXXIV ICPIG)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Two Kinds of Liquid Flows Induced by Plasma-jet Irradiation2019

    • Author(s)
      T. Kawasaki, K. Nishida, M. Kawaguchi, Y. Hazama, and F. Mitsugi
    • Organizer
      XI International Symposium on Electrohydrodynamics (ISEHD 2019)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Distribution of reactive oxygen species in water irradiated with oxygen radicals2019

    • Author(s)
      N. Iio, G. Vladislav, T. Kawasaki, M. Hori, and M. Ito
    • Organizer
      11th International Symposium on Advanced Plasma Science and its Applications for Nitrides and Nanomaterials 12th International Conference on Plasma-Nano Technology & Science
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Downward Liquid Flow Induced by Plasma Jet Irradiation2018

    • Author(s)
      T. Kawasaki, M. Kawaguchi, K. Nishida, and Y. Hazama
    • Organizer
      The 7th International Workshop and the 6th International Mini Workshop on Solution Plasma and Molecular Technology
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Effects of plasma irradiation conditions on flows induced in liquid2018

    • Author(s)
      T. Kawasaki, M. Kawaguchi, K. Nishida, and Y. Hazama
    • Organizer
      The eleventh International Symposium on Non-Thermal/Thermal Plasma Pollution Control Technology and Sustainable Energy
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] OBSERVATION OF REACTIVE OXYGEN SPECIES EMITTED BY PLASMA JETS USING KI-STARCH METHOD2018

    • Author(s)
      F. Mitsugi and T. Kawasaki
    • Organizer
      16thInternational Symposium on High Pressure Low Temperature Plasma Chemistry
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] プラズマジェット照射が誘起する液体流に雰囲気ガスが与える影響2018

    • Author(s)
      川崎敏之, 川口諒, 西田佳祐, 間結夏, 内田儀一郎, 竹中弘祐, 古閑一憲, 節原裕一, 白谷正治
    • Organizer
      第42回静電気学会全国大会
    • Related Report
      2018 Research-status Report
  • [Presentation] プラズマ照射により液深さ方向に輸送される活性酸素の実験的同定2018

    • Author(s)
      川崎敏之
    • Organizer
      第34回九州・山口プラズマ研究会
    • Related Report
      2018 Research-status Report
  • [Presentation] Supply of Reactive Oxygen Species in a Tissue Model by Atmospheric-pressure Plasma-jet Irradiation2018

    • Author(s)
      T. Kawasaki
    • Organizer
      第28回日本MRS年次大会
    • Related Report
      2018 Research-status Report
  • [Presentation] Measurement of water cluster ions in plasma plume of an atmospheric pressure He plasma jet2018

    • Author(s)
      J.-S. Oh, Y. Nakai, T. Kawasaki, T. Shirafuji, M. Hori, M. Hiramatsu, and M. Ito
    • Organizer
      The 40th International Symposium on Dry Process
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] プラズマ照射により液中に輸送される活性酸素の二次元分布可視化2018

    • Author(s)
      川崎敏之
    • Organizer
      第3回グリーンイノベーションセミナー&第7回プラズマバイオ異分野融合セミナー
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] Estimation of transportation rate of reactive oxygen species in tissue model by plasma irradiation using a KI-starch gel reagent2017

    • Author(s)
      T. Kawasaki, T. Adachi, S. Anan, S. Takei, R. Betsumiya, S. Yamanouchi, and T. Ito
    • Organizer
      10th Asia-Pacific International Symposium on the Basics and Applications of Plasma Technology
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Visualization of ROS Distribution Generated by Atmospheric Pressure Plasma Jet2017

    • Author(s)
      S. Kusumegi, Y. Tokunaga, T. Kawasaki, F. Mitsugi
    • Organizer
      10th Asia-Pacific International Symposium on the Basics and Applications of Plasma Technology
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Measurements of Pressure Wave Generated by Atmospheric Plasma Jets Using Fibered Optical Wave MicrophoneV=2017

    • Author(s)
      S. Kusumegi, Y. Tokunaga, T. Kawasaki, T. Nakamiya, Y. Sonoda, F. Mitsugi
    • Organizer
      10th Asia-Pacific International Symposium on the Basics and Applications of Plasma Technology
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] プラズマ照射によって液体中に誘起される流れの定量解析2017

    • Author(s)
      川崎敏之, 足立拓也, 阿南翔太, 武井彰汰, 別宮竜之介, 山ノ内翔太, 伊東巧, 古閑一憲, 白谷正治
    • Organizer
      Plasma Conference 2017
    • Related Report
      2017 Research-status Report
  • [Presentation] プラズマジェット照射による2種類の液中誘起流の発生メカニズム解明に向けて2017

    • Author(s)
      川崎敏之, 川口諒, 西田佳祐, 間結夏, 古閑一憲, 白谷正治, 池畑義人
    • Organizer
      第33回 九州・山口プラズマ研究会
    • Related Report
      2017 Research-status Report
  • [Presentation] プラズマジェット照射時のターゲットにおけるROS分布の可視化2017

    • Author(s)
      久壽米木捷太, 徳永悠, 川崎敏之, 光木文秋
    • Organizer
      平成30年度(第71回)電気・情報関係学会九州支部連合大会
    • Related Report
      2017 Research-status Report
  • [Presentation] プラズマ照射によって液状媒体深さ方向に供給されるROSの同定への試み2017

    • Author(s)
      伊東巧, 武井彰汰, 別宮竜乃介, 古閑一憲, 白谷正治, 川崎敏之
    • Organizer
      平成30年度(第71回)電気・情報関係学会九州支部連合大会
    • Related Report
      2017 Research-status Report
  • [Presentation] プラズマ照射による模擬生体内ROS透過率の推定2017

    • Author(s)
      武井彰汰, 古閑一憲, 白谷正治, 川崎敏之
    • Organizer
      平成30年度(第71回)電気・情報関係学会九州支部連合大会
    • Related Report
      2017 Research-status Report
  • [Presentation] プラズマジェット照射によって液状ターゲットに供給されるROSの二次元分布に周囲ガスが与える影響2017

    • Author(s)
      足立拓也, 阿南翔太, 山ノ 内翔太, 内田儀一朗, 竹中弘祐, 古閑一憲, 節原裕一, 白谷正治, 川崎敏之
    • Organizer
      平成30年度(第71回)電気・情報関係学会九州支部連合大会
    • Related Report
      2017 Research-status Report
  • [Presentation] プラズマ照射条件が模擬生体内のROS透過率に与える影響2017

    • Author(s)
      川崎敏之, 足立拓也, 阿南翔太, 武井彰汰, 別宮竜之介, 山ノ内翔太, 伊東巧
    • Organizer
      第41回静電気学会全国大会
    • Related Report
      2017 Research-status Report
  • [Presentation] Storage and Transportation of Reactive Oxygen Species in Tissue Phantom Irradiated with Non-thermal Plasma Jet2017

    • Author(s)
      *T. Kawasaki, K. Koga, and M. Shiratani
    • Organizer
      IUMRS-ICAM 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Optical wave microphone measurements on pressure waves emitted from plasma jets2017

    • Author(s)
      Fumiaki Mitsugi, Shota Kusumegi, Shin-Ichi Aoqui, Toshiyuki Nakamiya, Yoshito Sonoda and Toshiyuki Kawasaki
    • Organizer
      International Conference on Phenomena in Ionized Gases
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Transportation of reactive oxygen species through a tissue phantom by atmospheric-pressure plasma jet2017

    • Author(s)
      T. Kawasaki, G. Kuroeda, R. Sei, M. Yamaguchi, R. Yoshinaga, R. Yamashita, H. Tasaki
    • Organizer
      International Symposium on Electrohydrodynamics 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] プラズマジェット照射による酸化反応の KI-デンプン試薬による二次元分布可視化2017

    • Author(s)
      川崎敏之, 古閑一憲, 白谷正治, 内田儀一郎, 竹中弘祐, 節原裕一
    • Organizer
      大阪大学接合科学研究所第14回産学連携シンポジウム
    • Related Report
      2017 Research-status Report
    • Invited
  • [Book] 高電圧パルスパワー工学2018

    • Author(s)
      高木浩一,金澤誠司,猪原哲,上野崇寿,川崎敏之,高橋克幸
    • Total Pages
      280
    • Publisher
      理工図書株式会社
    • ISBN
      9784844608714
    • Related Report
      2017 Research-status Report
  • [Remarks]

    • URL

      http://www3.nishitech.ac.jp/education/teachers/tkawasak

    • Related Report
      2019 Annual Research Report
  • [Remarks]

    • URL

      http://www.nishitech.ac.jp/cgi-bin/www/researchdb/researchdb-output.pl

    • Related Report
      2019 Annual Research Report

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Published: 2017-04-28   Modified: 2021-02-19  

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