| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
In eukaryotic cells, DNA macromolecules with a length exceeding 1 meter are densely folded and exist in cells with a size of several μm. Artificial experimental models are needed to explain the higher order structure and behavior of DNA in cellular-like environment. In this study, we constructed an "artificial cell model" method for encapsulating very ling genomic DNA in polymer capsules of several μm size. Using this experimental model, we made clear the behavior of DNA confined in the cell-sized space. The experimental methodology proposed in this study is promising for gene delivery and related biomedical applications.
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