| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
The aim of this research project was to explore the catalytic functions of selenocysteine. In this project, the following outcomes were obtained. An easy and efficient method to produce selenocysteine derivatives from natural amino acid serine was established. Using the obtained selenocysteine derivatives, novel catalytic organic transformation reactions were found, mimics of selenoenzymes were developed, a convenient synthetic method was established for selenoglutathione, a selenoinsulin analog was synthesized, and the synthesis of cyclic selenopeptides was achieved by application of intramolecular native chemical ligation.
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