Development of catalysts for C-S coupling reactions in water
| Project/Area Number |
17K05814
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Inorganic chemistry
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| Research Institution | Osaka City University |
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Principal Investigator |
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| Project Period (FY) |
2017-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2017: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 硫黄化合物 / 金属錯体 / 糖修飾配位子 / 炭素・硫黄カップリング / 糖 / Ｎ－ヘテロ環カルベン / 金属錯体触媒 / 炭素硫黄結合 / 触媒 / 遷移金属触媒 / ヘテロカップリング / 硫黄含有化合物 |
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| Outline of Final Research Achievements |
Investigation of new catalysts for coupling reactions in water, which is a safer solvent compared with toxic and/or flammable organic solvents, was performed. Sugar units were introduced into metal complex catalysts to enhance their water solubility. Palladium, nickel, and rhodium were used to synthesize metal complexes. The complexes worked as catalysts for carbon-carbon coupling reactions in water but not for carbon-sulfur coupling.
Multinuclear complexes containing sulfide ligands were also synthesized. Electrochemical measurements of these complexes in the presence of alkyl halides suggested their potential of applications for coupling reactions.
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| Academic Significance and Societal Importance of the Research Achievements |
有機化合物の合成に一般的に用いられる有機溶媒は毒性があるものや可燃性のものが多いため、代わりに水を用いることができれば作業環境や環境保全に役立つ。本研究では、水中での有機合成に用いることのできる触媒開発をめざし、金属錯体に水への溶解性が非常に高い糖を導入する合成法を確立した。また、合成した水溶性の金属錯体が、水中での炭素－炭素結合生成反応の触媒として有用であることを明らかにした。
この研究成果は、薬品や化成品の製造における持続可能社会の確立に貢献するものである。
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Report
(5 results)
Research Products
(25 results)
