• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Development of oxygen-responsive lanthanide complexes for biological applications

Research Project

Project/Area Number 17K05818
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Inorganic chemistry
Research InstitutionKindai University

Principal Investigator

Nakai Hidetaka  近畿大学, 理工学部, 准教授 (70377399)

Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords合成化学 / 光物性 / 酸素プローブ / ランタニド錯体 / 発光
Outline of Final Research Achievements

Our researches had been focused on the design and synthesis of new oxygen-responsive lanthanide complexes in order to obtain fundamental knowledge in the development of new medical and diagnostic technologies using luminescent lanthanide complexes.
As a result, we have obtained basic knowledge on ligand and complex designs for the development of “oxygen-responsive lanthanide complexes for biological applications”. In addition, we have succeeded in creating the “oxygen probes” using our prototype oxygen-responsive lanthanide complexes. Furthermore, we have found that the newly developed ligands can provide oxygen-responsive lanthanide complexes with “chiral molecule”-responsive function.

Academic Significance and Societal Importance of the Research Achievements

プロトタイプの酸素応答性ランタニド錯体を用いて、f-f発光を利用した酸素プローブとしては世界最高の性質を示す酸素プローブを作成することができた。また、窒素下では緑・空気下では黄・酸素下では赤色に発光色が変化する比色酸素プローブの開発にも成功した。さらに、「キラル分子に応答する機能」を有する酸素応答性ランタニド錯体は、生体内に存在するアミノ酸などのキラル分子を特異的に認識できる可能性を秘めた新規な化合物である。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (9 results)

All 2019 2018 2017

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (8 results) (of which Int'l Joint Research: 4 results)

  • [Journal Article] Luminescent Tb(III) and Sm(III) Complexes with a 1,4,7-Triazacyclononane-based Tris-aryloxide Ligand for High-performance Oxygen Sensors.2017

    • Author(s)
      Nakai, Hidetaka;* Kuyama, Masafumi; Seo, Juncheol; Goto, Takahiro; Matsumoto, Takahiro; Ogo, Seiji.
    • Journal Title

      Dalton Trans.

      Volume: 46 Issue: 28 Pages: 9126-9130

    • DOI

      10.1039/c7dt01388d

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Presentation] 1,4,7,10-テトラアザシクロドデカン骨格およびビフェニル基を有するガドリニウム錯体の合成と構造および発光特性2019

    • Author(s)
      横山直紀、中井英隆
    • Organizer
      錯体化学会第69回討論会
    • Related Report
      2019 Annual Research Report
  • [Presentation] ビフェニル基を有する酸素応答性テルビウム錯体の合成と構造および発光特性2019

    • Author(s)
      北村拓也、中井英隆
    • Organizer
      日本化学会第99春季年会
    • Related Report
      2018 Research-status Report
  • [Presentation] 1,4,7,10-テトラアザシクロドデカン骨格およびビフェニル基を有する酸素応答性テルビウム錯体の合成と構造および発光特性2019

    • Author(s)
      横山直紀、中井英隆
    • Organizer
      日本化学会第99春季年会
    • Related Report
      2018 Research-status Report
  • [Presentation] ビフェニル基を有するガドリニウム錯体の合成と構造および発光特性2018

    • Author(s)
      北村拓也、中井英隆
    • Organizer
      日本化学会第98春季年会
    • Related Report
      2017 Research-status Report
  • [Presentation] Development of high-efficiency photo-responsive metal complexes2017

    • Author(s)
      Nakai Hidetaka
    • Organizer
      International symposium on chemistry for solar energy applications 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] A photo-responsive gadolinium(III) complex having biphenyl groups2017

    • Author(s)
      Kitamura Takuya、Nakai Hidetaka
    • Organizer
      International symposium on chemistry for solar energy applications 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Development of high-performance oxygen sensors using a luminescent terbium(III) complex2017

    • Author(s)
      Yoshimura Seiya、Nakai Hidetaka
    • Organizer
      International symposium on chemistry for solar energy applications 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] A photo-responsive gadolinium(III) complex having 1,4,7,10-tetraazacyclododecane skeleton2017

    • Author(s)
      Yokoyama Naoki、Nakai Hidetaka
    • Organizer
      International symposium on chemistry for solar energy applications 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research

URL: 

Published: 2017-04-28   Modified: 2021-02-19  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi