| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2017: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Outline of Final Research Achievements |
Polyketides constitute a class of compounds with a wide variety of structures and oxidation states. Despite the diversity of polyketide molecules, they are synthesized via the common iterative process in nature. By mimicking the biological system, we established the iterative synthetic method for affording various types of polyketides. Chain elongation of a carboxylic acid with malonic acid half thioester was used as the key reaction for the iterative synthesis. It was shown that different types of polyketides could be synthesized by repeating a few kinds of reactions. The iterative method was extended to the solid-phase synthesis for obtaining polyketides with simple operations.
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