| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
|---|
| Outline of Final Research Achievements |
Both of the A-E and H-M ring segments of ciguatoxin 3C (CTX3C), a marine polycyclic ether, were synthesized via the intramolecular allylation followed by ring-closing metathesis, stereo-selectively. The segments synthesized were connected by esterification and subsequent ring-closing metathesis. Furthermore, the inter- and intramolecular double allylation protocol newly developed was successfully applied to the total synthesis of marine THP macrolides, dactylolide and enigmazole A.
|
