| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Outline of Final Research Achievements |
Copper-catalyzed borylative substitution reaction of allylic phosphates with diaminonaphtalene-substituted unsymmetrical diboron has been developed. A diaminonaphthalene-substituted boron moiety with diminished Lewis acidity has been found to be installed chemoselectively into the gamma position of the allylic phosphates, leading to the formation of various allylic boron compounds in high yields. In addition, we have succeeded in synthesizing an anthranilamide-substituted unsymmetrical diboron, which can be utilized for palladium-catalyzed borylative substitution of aryl halides. The resulting anthranilamide-sustituted aryl boron compounds have turned out to undergo direct Suzuki-Miyaura coupling without prior acidic deprotection. We have also achieved copper-catalyzed arylstannylation of arynes, which provides direct access to diverse biarylstannanes.
|
