| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
|---|
| Outline of Final Research Achievements |
Hydroalkylation of alkenes is a useful reaction to construct a carbon-carbon bond under neutral reaction conditions in a highly atom-economical manner. Intermolecular hydroalkylation of aliphatic terminal alkenes with 1,3-diketones under neutral conditions has been achieved using a cationic iridium catalyst. An active C-H bond of 1,3-diketones added to aliphatic terminal alkenes to give branched α-substituted 1,3-diketones in high yields. The products were easily converted to heterocycles. Similarly, hydroalkylation of aliphatic alkenes with β-ketoesters proceeded with the use of a cationic iridium complex and bidentate phosphine ligand to give selectively branched α-substituted β-ketoesters in high yields. One-pot sequential hydroalkylation/Krapcho dealkoxycarbonylation of alkenes and beta-ketoesters gave β-substituted ketones. These reactions provide a new method for extending a carbon chain from an aliphatic terminal alkene.
|
