| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
The purposes are development of novel methods for generating new low-valent titanium species and their use for developing new synthetic reactions and catalyses. Synthesis of novel vitamin D derivatives by using highly stereoselective cyclization of enyne substrates mediated by the divalent-titanium and their binding ability to the human vitamin D receptor protein were accomplished. In addition, the titanacyclopentene intermediates derived from enyne substrates and the divalent-titanium could react with bis-electronic reagent such as ethyl formate to undergo bicyclizaiton reaction affording bicyclic cyclopentenol derivatives. A new dual-mode polymerization method was also developed, in which a Ti(O-i-Pr)4/Me3SiCl/Mg reagent simultaneously promoted McMurry coupling of dialdehydes and cyclotrimerization of aldehyde-alkynes in one-flask and the reaction gave branched polymers. CpTiCl3/Mg/Me3SiCl reagents were developed as new low-valent titanium catalyst for alkyne [2+2+2] cycloaddition.
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