| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Outline of Final Research Achievements |
Polymer-supported chiral organocatalysts in which gel-type crosslinked polymer and polymer microsphere were employed as a support polymer were successfully synthesized. The catalytic performance of the resulting polymeric chiral organocatalysts were evaluated in the batch-type reaction such as Michael addition reaction.
The one-pot reaction catalyzed by polymer-supported acid and chiral base catalysts was performed. We found that the structure of support polymer, the position of chiral organocatalyst, and the kind of comonomer affected the reactivity and stereoselectivity in the reaction. The polymeric catalysts were efficiently recovered and reused several times without loss of the enantioselectivity.
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