Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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Outline of Final Research Achievements |
In this research, we tried development of the nucleic acid sensing probe based on molecule transfer which is triggered by a nucleic aromatic substituted (SNAr) reaction. In addition, the probe was designed to be easily multi-coloring by the click reaction. We synthesized three probes with different structures and evaluated them. As a result, it was confirmed that molecular transfer due to the SNAr reaction occurs in all the probes. In addition, we found that the NO2-CN type probe is the most desirable.
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