Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Outline of Final Research Achievements |
Metabolic pathways are a series of chemical reactions that occur within a cell. Since cellular metabolism is an indicator to analyze living cells, evaluation of the effect on metabolic activity is essential for drug development. In this study, we developed a system to analyze the concentration of metabolites in the vicinity of cells by immobilizing enzymes on a tip of a needle-shaped microelectrode. In combination with scanning electrochemical microscopy (SECM), it was possible to evaluate the glucose consumption of living cells.
|