| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
In order to elucidate the super-efficient energy transfer mechanism in the initial process of marine photosynthesis, we worked on the creation of fucoxanthin analogs. Fucoxanthin is structurally characterized by having a polyene skeleton in which a carbonyl group and an allene are conjugated. As a result, we achieved the following 1-3. 1) Development of conjugated polyene formation method using cross-coupling of bifunctional C5 diene building blocks, 2) Total synthesis of paracentrone with conjugated polyene skeleton similar to fucoxanthin and its improved synthesis, 3) Synthesis of 19-hexanoyloxyparacentrone. We also demonstrated that the Hiyama coupling reaction could be introduced into the newly developed conjugated polyene formation method.
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