| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
|---|
| Outline of Final Research Achievements |
A sensitive electrode was constructed to analyze the uric acid excretion from extra-renal, especially from intestine which is one of high risk factors of hyperuricemia. Excretion rate of uric acid in the rat intestine was calculated using time course data. A decrease in uric acid excretion rate was observed after administration of serum uric acid lowering drugs (benzbromarone, febuxostat, and topiroxostat). On the other hand, an increase in excretion rate of uric acid was observed in the rat model of chronic renal failure.
|
