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Effect of chemical environment changes in cell on DNA structures and functions

Research Project

Project/Area Number 17K05941
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Bio-related chemistry
Research InstitutionKonan University

Principal Investigator

Tateishi-Karimata Hisae  甲南大学, 先端生命工学研究所, 講師 (20593495)

Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2017: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords細胞内環境 / 構造変化 / 非二重らせん構造 / 転写変異 / がん遺伝子 / 定量的解析 / DNA構造 / 擬似細胞内環境 / センシング / がん / 転写 / 核酸 / 核酸非標準構造 / 溶液環境
Outline of Final Research Achievements

The relationship between the G-quadruplex formation and disease onset has received attention because the formation of G-quadruplexes induces mutations in various biological reactions. Here, we focused on the intracellular environment peculiar to diseases such as cancer and neurodegenerative diseases, and analyzed the effect of environmental changes in the cell on the structure and function of DNA. Furthermore, based on the findings, we have developed an artificial nucleic acid that stabilizes the G-quadruplex in order to suppress biological reactions in diseased cells.

Academic Significance and Societal Importance of the Research Achievements

DNAの非二重らせん構造である四重らせん構造が形成されると、転写・翻訳反応など、生体内の重要な反応の変異が誘発さるため、四重らせん構造の形成と疾患発症機構との関連性が注目されている。本研究では、DNAは遺伝子の情報を保持するという役割をもつだけでなく、DNAの“構造”を介して生体反応を制御するという“機能”をもつことを試験管内、細胞内の実験において示すことができた。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (67 results)

All 2020 2019 2018 2017 Other

All Int'l Joint Research (6 results) Journal Article (18 results) (of which Int'l Joint Research: 10 results,  Peer Reviewed: 18 results,  Open Access: 14 results) Presentation (39 results) (of which Int'l Joint Research: 15 results,  Invited: 9 results) Book (1 results) Remarks (3 results)

  • [Int'l Joint Research] Slovenian NMR Centre(スロベニア)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] Changchun Univ. of Chinese Medicine(中国)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] Slovenian NMR Centre(スロベニア)

    • Related Report
      2018 Research-status Report
  • [Int'l Joint Research] U of Chinese Academy of Sciences(中国)

    • Related Report
      2018 Research-status Report
  • [Int'l Joint Research] University of Calcutta(インド)

    • Related Report
      2017 Research-status Report
  • [Int'l Joint Research] Slovenian NMR centre(スロベニア)

    • Related Report
      2017 Research-status Report
  • [Journal Article] Effect of Potassium Concentration on Triplex Stability under Molecular Crowding Conditions2020

    • Author(s)
      Teng Ye、Tateishi-Karimata Hisae、Ohyama Tatsuya、Sugimoto Naoki
    • Journal Title

      Molecules

      Volume: 25 Issue: 2 Pages: 387-387

    • DOI

      10.3390/molecules25020387

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Chemical biology of non-canonical structures of nucleic acids for therapeutic applications2020

    • Author(s)
      Tateishi-Karimata Hisae、Sugimoto Naoki
    • Journal Title

      Chemical Communications

      Volume: 56 Issue: 16 Pages: 2379-2390

    • DOI

      10.1039/c9cc09771f

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] New Modified Deoxythymine with Dibranched Tetraethylene Glycol Stabilizes G-quadruplex Structures2020

    • Author(s)
      H. Tateishi-Karimata, T. Ohyama, T. Muraoka, S. Tanaka, K. Kinbara, and N. Sugimoto
    • Journal Title

      Molecules

      Volume: 25 Issue: 3 Pages: 705-705

    • DOI

      10.3390/molecules25030705

    • NAID

      120006811187

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Hydroxyl groups in cosolutes regulate the G-quadruplex topology of telomeric DNA2020

    • Author(s)
      Tateishi-Karimata Hisae、Banerjee Dipanwita、Ohyama Tatsuya、Matsumoto Saki、Miyoshi Daisuke、Nakano Shu-ich、Sugimoto Naoki
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 525 Issue: 1 Pages: 177-183

    • DOI

      10.1016/j.bbrc.2020.02.045

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Thrombin binding aptamer G-quadruplex stabilized by pyrene-modified nucleotides2020

    • Author(s)
      Kovacic Matic、Podbevsek Peter、Tateishi-Karimata Hisae、Takahashi Shuntaro、Sugimoto Naoki、Plavec Janez
    • Journal Title

      Nucleic Acids Research

      Volume: 48 Issue: 7 Pages: 3975-3986

    • DOI

      10.1093/nar/gkaa118

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] RNA G-Quadruplexes Facilitate RNA Accumulation in G-Rich Repeat Expansions2020

    • Author(s)
      Teng Ye、Tateishi-Karimata Hisae、Sugimoto Naoki
    • Journal Title

      Biochemistry

      Volume: 59 Issue: 21 Pages: 1961-2040

    • DOI

      10.1021/acs.biochem.0c00130

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Validation of the nearest-neighbor model for Watson?Crick self-complementary DNA duplexes in molecular crowding condition2019

    • Author(s)
      Ghosh Saptarshi、Takahashi Shuntaro、Endoh Tamaki、Tateishi-Karimata Hisae、Hazra Soumitra、Sugimoto Naoki
    • Journal Title

      Nucleic Acids Research

      Volume: 47 Issue: 7 Pages: 0-0

    • DOI

      10.1093/nar/gkz071

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] C-rich sequence in a non-template DNA strand regulates structure change of G-quadruplex in a template strand during transcription2019

    • Author(s)
      Y. Teng, H. Tateishi-Karimata, and N. Sugimoto
    • Journal Title

      Bull. Chem. Soc. Jpn.

      Volume: 92 Issue: 3 Pages: 572-577

    • DOI

      10.1246/bcsj.20180298

    • NAID

      130007614869

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Pursuing origins of (poly)ethylene glycol-induced G-quadruplex structural modulations2018

    • Author(s)
      M. Trajkovski, T. Endoh, H. Tateishi-Karimata, T. Ohyama, S. Tanaka, J. Plavec, N. Sugimoto
    • Journal Title

      Nucleic Acids Research

      Volume: 46 Issue: 8 Pages: 4301-4315

    • DOI

      10.1093/nar/gky250

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] An anionic phthalocyanine decreases NRAS expression by breaking down its RNA G-quadruplex2018

    • Author(s)
      K. Kawauchi, W. Sugimoto, T. Yasui, K. Murata, K. Itoh, K. Takagi, T. Tsuruoka, K. Akamatsu, H. Tateishi-Karimata, N. Sugimoto, and D. Miyoshi
    • Journal Title

      Nat. Commum

      Volume: 9 Issue: 1 Pages: 2271-2271

    • DOI

      10.1038/s41467-018-04771-y

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mirror-Image Dependence: Targeting Enantiomeric G-Quadruplex DNA Using Triplex Metallohelices2018

    • Author(s)
      C. Zhao、H. Song、P. Scott、A. Zhao、H. Tateishi-Karimata、N. Sugimoto、J. Ren、X. Qu
    • Journal Title

      Angew. Chem. Int. Ed.

      Volume: 57 Issue: 48 Pages: 15723-15727

    • DOI

      10.1002/anie.201809207

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A Turn-On Detection of DNA Sequences by Means of Fluorescence of DNA-Templated Silver Nanoclusters via Unique Interactions of a Hydrated Ionic Liquid2018

    • Author(s)
      Y. Teng,H. Tateishi-Karimata、T. Tsuruoka, N. Sugimoto
    • Journal Title

      Molecules

      Volume: 23 Issue: 11 Pages: 2889-2889

    • DOI

      10.3390/molecules23112889

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] テトラエチレングリコールで修飾されたグアニン四重鎖の安定性の分子動力学計算による解析2018

    • Author(s)
      大山達也, 建石寿枝, 田中成典, 杉本直己
    • Journal Title

      日本核酸化学会誌

      Volume: 2 Pages: 3-10

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Destabilization of DNA G-Quadruplexes by Chemical Environment Changes during Tumor Progression Facilitates Transcription2018

    • Author(s)
      Tateishi-Karimata Hisae、Kawauchi Keiko、Sugimoto Naoki
    • Journal Title

      Journal of the American Chemical Society

      Volume: 140 Issue: 2 Pages: 642-651

    • DOI

      10.1021/jacs.7b09449

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Alkylating probes for the G-quadruplex structure and evaluation of the properties of the alkylated G-quadruplex DNA2018

    • Author(s)
      Sato Norihiro、Takahashi Shuntaro、Tateishi-Karimata Hisae、Hazemi Madoka E.、Chikuni Tomoko、Onizuka Kazumitsu、Sugimoto Naoki、Nagatsugi Fumi
    • Journal Title

      Org. Biomol. Chem.

      Volume: 16 Issue: 9 Pages: 1436-1441

    • DOI

      10.1039/c7ob03179c

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Drastic stability change of X-X mismatch in d(CXG) trinucleotide repeat disorders under molecular crowding condition2018

    • Author(s)
      Teng Ye、Pramanik Smritimoy、Tateishi-Karimata Hisae、Ohyama Tatsuya、Sugimoto Naoki
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 496 Issue: 2 Pages: 601-607

    • DOI

      10.1016/j.bbrc.2018.01.083

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Newly characterized interaction stabilizes DNA structure: oligoethylene glycols stabilize G-quadruplexes CH?π interactions2017

    • Author(s)
      Tateishi-Karimata Hisae、Ohyama Tatsuya、Muraoka Takahiro、Podbevsek Peter、Wawro Adam M.、Tanaka Shigenori、Nakano Shu-ichi、Kinbara Kazushi、Plavec Janez、Sugimoto Naoki
    • Journal Title

      Nucleic Acids Research

      Volume: 45 Issue: 12 Pages: 7021-7030

    • DOI

      10.1093/nar/gkx299

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Unexpected Position-Dependent Effects of Ribose G-Quartets in G-Quadruplexes2017

    • Author(s)
      Zhou Jun、Amrane Samir、Rosu Frederic、Salgado Gilmar F.、Bian Yunqiang、Tateishi-Karimata Hisae、Largy Eric、Korkut Dursun Nizam、Bourdoncle Anne、Miyoshi Daisuke、Zhang Jian、Ju Huangxian、Wang Wei、Sugimoto Naoki、Gabelica Valerie、Mergny Jean-Louis
    • Journal Title

      Journal of the American Chemical Society

      Volume: 139 Issue: 23 Pages: 7768-7779

    • DOI

      10.1021/jacs.7b00648

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] Nucleic Acids Chemistry beyond the Watson-Crick Double Helix (57): Parameters for prediction of DNA duplex stabilities under the crowding conditions2020

    • Author(s)
      S. Ghosh, S.Takahashi, T. Ohyama, T. Endo, H. Tateishi-Karimata, N.Sugimoto
    • Organizer
      日本化学会第100回春季年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Nucleic Acids Chemistry beyond the Watson-Crick Double Helix (59): Prediction method for the stability of RNA/DNA hybrid duplex under a physiological condition2020

    • Author(s)
      D. Banerjee, H. Tateishi-Karimata, T. Ohyama, M. Tranjkovski, M. Toplishek, S. Takahashi, T. Endoh, J. Plavec, N. Sugimoto
    • Organizer
      日本化学会第100回春季年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 脱ワトソン・クリックの核酸化学 (63):分子シュミレーションによるGGGGCCリピートのRNA四重鎖とジペプチドリピートの集積メカニズムの解析2020

    • Author(s)
      大山達也, 建石寿枝, 田中成典, 杉本直己
    • Organizer
      日本化学会第100回春季年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Nucleic Acids Chemistry beyond the Watson-Crick Double Helix (64): Effects of malignant alteration in cancer cells on the DNA structures and transcript mutations2020

    • Author(s)
      H. Tateishi-Karimata, K. Kawauchi, T. Ohyama, N. Sugimoto
    • Organizer
      日本化学会第100回春季年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 神経変性疾患に関与するRNA/ペプチドによるPhase separationの機構解析2019

    • Author(s)
      建石寿枝, Ye Teng, 大山達也, 田中成典, 杉本直己
    • Organizer
      第2回LLPS(液液相分離)研究会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] DNA四重らせん構造はがんの悪性化を制御しているのか2019

    • Author(s)
      建石寿枝, 杉本直己
    • Organizer
      第22回生命化学研究会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 神経変性疾患に関わるRNAリピート配列とペプチドの相互作用解析2019

    • Author(s)
      建石 寿枝, Ye Teng, 大山 達也,田中 成典, 杉本 直己
    • Organizer
      第13回バイオ関連化学シンポジウム
    • Related Report
      2019 Annual Research Report
  • [Presentation] Role for G-quadruplexes of Nucleic Acids During Tumor Progression2019

    • Author(s)
      H. Tateishi-Karimata and N. Sugimoto
    • Organizer
      10th RSC-CSJ Joint Symposium
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 神経変性疾患に関わるRNA・ペプチドの細胞内での相互作用解析2019

    • Author(s)
      建石寿枝, 杉本直己
    • Organizer
      大阪大学蛋白研セミナー/第3回LLPS研究会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Effects of malignant alteration in cancer cells on the DNA G-quadruplex formation and transcript mutations2019

    • Author(s)
      H. Tateishi-Karimata, K. Kawauchi and N. Sugimoto
    • Organizer
      International Conference on Genomes and AI: From Packing to Regulation
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 分子夾雑で遺伝子発現を制御する2019

    • Author(s)
      建石寿枝
    • Organizer
      第9会CSJ化学フェスタ文科省科研費新学術領域研究「分子夾雑の生命化学」特別企画:細胞の中身を化学する!
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Effect of RNA structures on RNA and RNA/peptide accumulation in repeat-expansion disorders2019

    • Author(s)
      H. Tateihsi-Karimata and N. Sugimoto
    • Organizer
      Advances in Noncanonical Nucleic Acids "ANNA2019"
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Effect of RNA topology on phase separation of peptides and proteins in neurodegenerative diseases2019

    • Author(s)
      H. Tateishi-Karimata, Y. Teng, T. Ohyama, S. Tanaka, E. Chatani, N. Sugimoto
    • Organizer
      第46回国際核酸化学シンポジウム
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of new prediction parameters for RNA/DNA hybrid duplex stability under a physiological buffer condition2019

    • Author(s)
      D. Banerjee, H. Tateishi-Karimata, T. Ohyama, T. Endoh, S. Takahashi, N. Sugimoto
    • Organizer
      第46回国際核酸化学シンポジウム
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Molecular Crowding Regulates RNA Phase Separations in Repeat Expansion Disorders2019

    • Author(s)
      Y. Teng, H. Tateishi-Karimata, and N. Sugimoto
    • Organizer
      Gordon Research Conference(RNA Nanotechnology)
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Elucidation for mechanism of diseases caused by non-canonical structures of DNA and regulation for DNA function2019

    • Author(s)
      H. Tateishi-Karimata
    • Organizer
      日本化学会第99回春季年会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] Nucleic Acids Chemistry beyond the Watson-Crick Double Helix(50):Phase separation of RNA/peptides in neurodegenerative diseases is promoted by chemical environment changes in cell2019

    • Author(s)
      H. Tateishi-Karimata, Y. TENG, T.Ohyama, and N. Sugimoto
    • Organizer
      日本化学会第99回春季年会
    • Related Report
      2018 Research-status Report
  • [Presentation] 脱ワトソン・クリックの核酸化学 (51): DNAとクラウディング分子の相互作用の分子動力学計算と電子状態計算による定量的解析2019

    • Author(s)
      大山達也, 建石寿枝, 田中成典, 杉本直己
    • Organizer
      日本化学会第99回春季年会
    • Related Report
      2018 Research-status Report
  • [Presentation] Improved Efficiency of mRNA Sensing System by a Hydrated Ionic Liquid2018

    • Author(s)
      H. Tateishi-Karimata, N. Sugimoto
    • Organizer
      Gordon Research Conference(Bioanalytical Sensors)
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] がん細胞の悪性化に及ぼすDNA四重鎖構造の解離と転写変異の影響2018

    • Author(s)
      建石寿枝, 川内敬子, 杉本直己
    • Organizer
      日本核酸医薬学会第4回年会
    • Related Report
      2018 Research-status Report
  • [Presentation] カリウムチャネルはがん遺伝子の転写活性をDNA四重鎖の形成によって制御しているのか?2018

    • Author(s)
      建石寿枝, 川内敬子, 大山達也, 杉本直己
    • Organizer
      第12回バイオ関連化学シンポジウム
    • Related Report
      2018 Research-status Report
  • [Presentation] Gelation of RNA repeats in ALS/FTD is promoted in crowding conditions2018

    • Author(s)
      Teng Ye, 建石寿枝, 杉本直己
    • Organizer
      第12回バイオ関連化学シンポジウム
    • Related Report
      2018 Research-status Report
  • [Presentation] ポリエチレングリコールにより誘起される分子クラウディング環境がDNA四重鎖の構造安定性に与える影響の分子シミュレーション解析2018

    • Author(s)
      大山達也, 建石寿枝, 田中成典, 杉本直己
    • Organizer
      第12回バイオ関連化学シンポジウム
    • Related Report
      2018 Research-status Report
  • [Presentation] Investigation for effects of polyethylene glycols on DNA structure and stability using molecular dynamics simulations2018

    • Author(s)
      T. Ohyama, H.Tateishi-Karimata, S. Tanaka, and N. Sugimoto
    • Organizer
      第45回国際核酸化学シンポジウム
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Phase separation of repeated RNA with amyloid-like protein in neurodegenerative diseases is promoted by RNA G-quadruplexes2018

    • Author(s)
      Y. Teng, H. Tateishi-Karimata, and N. Sugimoto
    • Organizer
      第45回国際核酸化学シンポジウム
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Effect of G-quadruplex stability and structure in the template DNA on transcript mutations in normal and cancer cells2018

    • Author(s)
      H. Tateishi-Karimata, N. Sugimoto
    • Organizer
      第45回国際核酸化学シンポジウム
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Nucleic Acids Chemistry beyond the Watson-Crick Double Helix (38): Effects of malignant alteration in cancer cells on the G-quadruplex formation and transcript mutations2018

    • Author(s)
      H. Tateishi-Karimata, K. Kawaguchi, T, Ohyama, and N. Sugimoto
    • Organizer
      日本化学会第98回春季年会
    • Related Report
      2017 Research-status Report
  • [Presentation] 四重らせん構造による新規の転写制御機構:がん進行過程におけるノンコーディングDNAの役割2018

    • Author(s)
      建石寿枝
    • Organizer
      日本化学会第98回春季年会
    • Related Report
      2017 Research-status Report
  • [Presentation] Nucleic Acids Chemistry beyond the Watson-Crick Double Helix (37): The formation of RNA foci in repeat expansion disorders is promoted in molecular crowding conditions2018

    • Author(s)
      Y. Teng, H. Tateishi-Karimata, and N. Sugimoto
    • Organizer
      日本化学会第98回春季年会
    • Related Report
      2017 Research-status Report
  • [Presentation] Nucleic Acids Chemistry beyond the Watson-Crick Double Helix (42): Quantitative analysis for effects of molecular network by crowding agents on the G-quadruplex stability2018

    • Author(s)
      T. Ohyama, H. Tateishi-Karimata, and N. Sugimoto
    • Organizer
      日本化学会第98回春季年会
    • Related Report
      2017 Research-status Report
  • [Presentation] Effect of chemical environment change by malignant alteration in cancer cells on transcript productions from G-rich template DNAs2017

    • Author(s)
      H. Tateishi-Karimata, K. Kawauchi, T. Ohyama, and N. Sugimoto
    • Organizer
      The 2nd International Symposium on Biofunctional Chemistry (ISBC2017)
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 共溶質存在下におけるDNA水和水の熱力学的性質の解析2017

    • Author(s)
      中野美紀, 建石寿枝,田中成典、Tama Florence,宮下治、杉本直己
    • Organizer
      第31回分子シミュレーション討論会
    • Related Report
      2017 Research-status Report
  • [Presentation] 水和イオン液体中で機能するDNAセンサー2017

    • Author(s)
      建石寿枝, 杉本直己
    • Organizer
      第8回イオン液体討論会
    • Related Report
      2017 Research-status Report
  • [Presentation] The stabilization mechanism of cyclic naphthalene diimide binding with various topology of G-quadruplexe2017

    • Author(s)
      T. Ohyama, H. Tateishi-Karimata, S. Takahashi, S. Sato, S. Tanaka, S. Takenaka, and N. Sugimoto
    • Organizer
      第44回国際核酸化学シンポジウム
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Does molecular crowding regulate C9orf72-related ALS/FTD diseases by RNA foci formation?2017

    • Author(s)
      Y. Teng, H. Tateishi-Karimata, and N.Sugimoto
    • Organizer
      第44回国際核酸化学シンポジウム
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Relationship between malignant alteration in cancer cells and the transcript mutations byG-quadruplex formations in the template DNA2017

    • Author(s)
      H. Tateishi-Karimata, K. Kawauchi, T. Ohyama, and N.Sugimoto
    • Organizer
      第44回国際核酸化学シンポジウム
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Transcriptional regulation by DNA structural changes responsive chemical environments in cells during tumor progression2017

    • Author(s)
      H. Tateishi-Kartimata and N. Sugimoto,
    • Organizer
      Advances in Noncanonical Nucleic Acids 2017 “ ANNA2017”
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] がん進行過程におけるノンコーディング領域のDNA四重らせん構造による転写制御機構2017

    • Author(s)
      建石寿枝、川内敬子、大山達也, 杉本 直己
    • Organizer
      第11回バイオ関連化学シンポジウム
    • Related Report
      2017 Research-status Report
  • [Presentation] テトラエチレングリコール修飾核酸を活用した新しい逆転写制御法の開発2017

    • Author(s)
      建石 寿枝、大山 達也, 村岡 貴博, Peter Podbevsek、 Adam M. Wawro、田中 成典, 金原 数, Plavec Janez, 杉本 直己
    • Organizer
      日本核酸医薬学会第3回年会
    • Related Report
      2017 Research-status Report
  • [Book] CSJカレントレビュー「生命機能に迫る分子化学」2018

    • Author(s)
      建石寿枝、杉本直己
    • Publisher
      化学同人
    • Related Report
      2018 Research-status Report
  • [Remarks] 甲南大学先端生命工学研究所

    • URL

      http://www.konan-fiber.jp/index.php

    • Related Report
      2019 Annual Research Report
  • [Remarks] 甲南大学先端生命工学研究所(FIBER)

    • URL

      http://www.konan-fiber.jp/index.php

    • Related Report
      2018 Research-status Report
  • [Remarks] 甲南大学先端生命工学研究所HP 研究業績

    • URL

      http://www.konan-fiber.jp/index.php

    • Related Report
      2017 Research-status Report

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Published: 2017-04-28   Modified: 2021-02-19  

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