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Practical design of mechanical load responsive self-reinforced metallic implants against physiological loading

Research Project

Project/Area Number 17K06071
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Materials/Mechanics of materials
Research InstitutionKindai University

Principal Investigator

Nakai Masaaki  近畿大学, 理工学部, 准教授 (20431603)

Co-Investigator(Kenkyū-buntansha) 山本 衛  近畿大学, 生物理工学部, 准教授 (00309270)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywordsチタン合金 / 生体材料 / 変形誘起相変態 / 弾性率 / インプラント / オメガ相 / 骨 / 力学的特性
Outline of Final Research Achievements

In the metals with self-tunable elastic modulus developed by us, the elastic modulus is increased at the deformed part by the deformation-induced phase transformation, although low elastic modulus is maintained at the non-deformed part. In this project, as an application of the materials, the possibility of developing mechanical load responsive self-reinforced metallic implants was examined. When strain was systematically changed and applied to the materials, it was confirmed that the deformation-induced phase transformation occurred during elastic deformation. Further, when mechanical load was applied cyclically and then the change in elastic modulus was measured, an increase in the elastic modulus due to such the cyclic mechanical loading was obtained in a part of specimens. These experimental results indicate that the development of mechanical load responsive self-reinforced metallic implants is possible.

Academic Significance and Societal Importance of the Research Achievements

既に超高齢社会となっている我が国では、骨疾患の症例数も増加しており、金属インプラントの使用機会が増加している。それにもかかわらず、我が国の金属インプラントの市場は、外国製品に頼っており、国産製品が占める割合は極めて小さい。これまでの金属インプラント開発においては、認可取得の困難さから、従来の素材を新素材に置き換えた事例はほとんどない。しかし、新素材の適用により新たな機能を有する金属インプラントが開発されれば、実際にそれを利用する医師や患者にとって有益であるとともに、外国製品との差別化より競争力のある国内産業の創出にも貢献すると考えられる。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (30 results)

All 2019 2018 2017 Other

All Int'l Joint Research (5 results) Journal Article (7 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 7 results) Presentation (17 results) (of which Int'l Joint Research: 8 results,  Invited: 8 results) Remarks (1 results)

  • [Int'l Joint Research] Univ. Shanghai Sci. Tech.(中国)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] Michigan State Univ.(米国)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] Yildiz Tech. Univ.(トルコ)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] Yildiz Technical Univ.(トルコ)

    • Related Report
      2018 Research-status Report
  • [Int'l Joint Research] Univ. of Shanghai for Sci. and Technol.(中国)

    • Related Report
      2018 Research-status Report
  • [Journal Article] Low Springback and Low Young’s Modulus in Ti–29Nb–13Ta–4.6Zr Alloy Modified by Mo Addition2019

    • Author(s)
      Qiang Li, Qiang Qi, Junjie Li, Masaaki Nakai, Mitsuo Niinomi, Yuichro Koizumi, Kenta Yamanaka, DaiXiu Wei, Takayuki Nakano, Akihiko Chiba, Xuyan Liu, and Deng Pan
    • Journal Title

      MATERIALS TRANSACTIONS

      Volume: 60 Issue: 9 Pages: 1755-1762

    • DOI

      10.2320/matertrans.ME201912

    • NAID

      130007695396

    • ISSN
      1345-9678, 1347-5320
    • Year and Date
      2019-09-01
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Development of low-Young's modulus Ti-Nb-based alloys with Cr addition2019

    • Author(s)
      Q. Li, G. Ma, J. Li, M. Niinomi, M. Nakai, Y. Koizumi, D. Wei, T. Kakeshita, T. Nakano, A. Chiba, X. Liu, K. Zhou and D. Pan
    • Journal Title

      J. Mater. Sci.

      Volume: 54 Issue: 11 Pages: 8675-8683

    • DOI

      10.1007/s10853-019-03457-0

    • Related Report
      2019 Annual Research Report 2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Effect of Nb Content on Microstructures and Mechanical Properties of Ti-xNb-;2Fe Alloys2019

    • Author(s)
      Qiang Li, Pu Miao, Meifeng He, Junjie Li, Masaaki Nakai, Mitsuo Niinomi, Xuyan Liu, Takayoshi Nakano, Akihiko Chiba, Deng Pan
    • Journal Title

      Journal of Materials Engineering and Performance

      Volume: 28 Issue: 9 Pages: 5501-5508

    • DOI

      10.1007/s11665-019-04250-5

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Low Young’s Modulus Ti–Nb–O with High Strength and Good Plasticity2018

    • Author(s)
      Q. Li, D. Ma, J. Li, M. Niinomi, M. Nakai, Y. Koizumi, D. Wei, T. Kakeshita, T. Nakano, A. Chiba, K. Zhou and D. Pan
    • Journal Title

      MATERIALS TRANSACTIONS

      Volume: 59 Issue: 5 Pages: 858-860

    • DOI

      10.2320/matertrans.M2018021

    • NAID

      130006725928

    • ISSN
      1345-9678, 1347-5320
    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Deformation-induced ω-phase transformation in a β-type titanium alloy during tensile deformation2017

    • Author(s)
      Huihong Liu, MitsuoNiinomi, Masaaki Nakai, Ken Cho, Hidetoshi Fujii
    • Journal Title

      Scripta Materialia

      Volume: 130 Pages: 27-31

    • DOI

      10.1016/j.scriptamat.2016.10.036

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Change in Mechanical Properties of Biomechanical Ti–12Cr Subjected to Heat Treatment and Surface Modification Processing2017

    • Author(s)
      K. Niwa, T. Akahori, M. Niinomi, T. Hattori and M. Nakai
    • Journal Title

      MATERIALS TRANSACTIONS

      Volume: 58 Issue: 6 Pages: 951-957

    • DOI

      10.2320/matertrans.M2016432

    • NAID

      130005679047

    • ISSN
      1345-9678, 1347-5320
    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Metastable Zr-Nb alloys for spinal fixation rods with tunable Young’s modulus and low magnetic resonance susceptibility2017

    • Author(s)
      X.L. Zhao, L. Li, M. Niinomi, M. Nakai, D.L. Zhang and C. Suryanarayana
    • Journal Title

      Acta Biomater.

      Volume: 62 Pages: 372-384

    • DOI

      10.1016/j.actbio.2017.08.026

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] The Deformation Behavior of Oxygen-Modified Ti-29Nb-13Ta-4.6Zr(wt.%)2019

    • Author(s)
      V. Khademi, H.H. Liu, M. Nakai, M. Niinomi and C.J. Boehlert
    • Organizer
      The 14th World Conference on Titanium (Ti-2019)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effect of Titanium Plate Fixation on Bone Healing2019

    • Author(s)
      N.B. Abdullah, M. Nakai, Y. Kawamura, E. Yamamoto and M. Niinomi
    • Organizer
      The 14th World Conference on Titanium (Ti-2019)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Fatigue properties of beta-type Ti-Cr alloy with changeable Young's modulus2019

    • Author(s)
      M. Nakai and M. Niinomi
    • Organizer
      The 14th World Conference on Titanium (Ti-2019)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 共振式疲労試験法による生体用β型チタン合金の疲労特性の評価2019

    • Author(s)
      長峯昂平, 仲井正昭
    • Organizer
      軽金属学会第136回春期大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Effects of Young's modulus difference of titanium alloys and bone on bone formation2019

    • Author(s)
      ノルアインビンティアブドラー, 仲井正昭, 植木洸輔, 川村勇樹, 山本衛, 新家光雄
    • Organizer
      日本金属学会2019年秋期(第165回)大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Influence of titanium plate fixation on bone formation during healing period2019

    • Author(s)
      N.B. Abdullah, M. Nakai, Y. Kawamura, E. Yamamoto and M. Niinomi
    • Organizer
      日本金属学会2019年春期(第164回)大会
    • Related Report
      2018 Research-status Report
  • [Presentation] Fatigue strength of beta-type Ti-12Cr alloy under solutionized condition for biomedical applications2018

    • Author(s)
      M. Nakai, M. Niinomi and H.H. Liu
    • Organizer
      THERMEC'2018
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Role of oxygen in titanium alloys for biomedical applications2018

    • Author(s)
      M. Niinomi, Q. Li, T. Akahori, M. Nakai, T. Nakano and D. Pan
    • Organizer
      The 9th International Conference on Advanced Materials Processing (ICAMP-9)
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Influence of Young's modulus difference of titanium alloys on bone healing2018

    • Author(s)
      N.B. Abdullah, M. Nakai, Y. Kawamura, E. Yamamoto and M. Niinomi
    • Organizer
      日本金属学会2018年秋期(第163回)大会
    • Related Report
      2018 Research-status Report
  • [Presentation] 生体用β型チタン合金の整形外科用インプラントへの応用2018

    • Author(s)
      仲井正昭
    • Organizer
      第1回日本金属学会第4分野講演会「金属系バイオマテリアルサイエンスの新展開(Ⅰ)」
    • Related Report
      2018 Research-status Report
  • [Presentation] 生体用低弾性率チタン合金の特徴と生体組織との整合性2018

    • Author(s)
      仲井正昭, 山本衛, 新家光雄
    • Organizer
      第45回日本臨床バイオメカニクス学会
    • Related Report
      2018 Research-status Report
  • [Presentation] Development of biomedical beta-titanium alloys with deformation-induced changeable elastic modulus2018

    • Author(s)
      M. Nakai
    • Organizer
      1st International Symposium on Light Alloys and Composite Materials (ISLAC'18)
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Development of metallic biomaterials with changeable elastic modulus using deformation-induced phase transformation2017

    • Author(s)
      M. Nakai and M. Niinomi
    • Organizer
      Japan-Korea International Symposium on Materials Science and Technology 2017 (JKMST2017)
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Controlling mechanical property by deformation-induced omega phase in biomedical beta-titanium alloys2017

    • Author(s)
      M. Nakai
    • Organizer
      KIM-JIM symposium -Interplay between,phase transformation and deformation in advanced structural materials-
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 生体用弾性率可変型チタン合金の化学組成最適化2017

    • Author(s)
      仲井正昭, 新家光雄
    • Organizer
      第56回日本生体医工学会大会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] 生体用チタン合金のヤング率制御と合金開発2017

    • Author(s)
      仲井正昭, 新家光雄
    • Organizer
      日本学術振興会鋳物第24委員会鋳造プロセス分科会第19回会議
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] 医療用チタン合金間で生じる摩擦摩耗の特徴2017

    • Author(s)
      仲井正昭, 新家光雄, 李允碩
    • Organizer
      日本真空学会機能薄膜部会ナノ構造機能創成専門部会第8回研究会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Remarks] 近畿大学理工学部機械工学科

    • URL

      http://www.mec.kindai.ac.jp/

    • Related Report
      2019 Annual Research Report

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Published: 2017-04-28   Modified: 2021-02-19  

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