Long-range Surface Plasmon Based Sensitive Biosensor Using Moth-eye Structure Having Large Surface Area

• Project/Area Number: 17K06375
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Electron device/Electronic equipment
• Research Institution: Niigata University
• Principal Investigator: Shinbo Kazunari 新潟大学, 自然科学系, 教授 (80272855)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2017: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 表面プラズモン / バイオセンサ / モスアイ構造 / 長距離伝搬表面プラズモン / センサ / 異常透過光 / テフロン / サイトップ

Outline of Final Research Achievements

In this study, we attempted to develop sensitive long-range surface plasmon resonance (LRSPR) sensors by preparing large-area surface using moth-eye structure and/or small particles with nanometer size. The sensors exhibited a remarkable peak shift for a LbL film deposition, compared to a sensor without the structure. Furthermore, the nano structures with fluorinated polymers resulted in sharp LRSPR peaks and were useful for development of practical sensors.

Academic Significance and Societal Importance of the Research Achievements

様々な疾病の診断や健康管理のために、高感度なバイオセンサが求められている。高感度化の方法の一つとして、表面積を大きくして物質の吸着量を増やす手法があげられる。本研究では、大きさ数百ナノメートルの突起の配列からなるモスアイ（蛾の目）構造が大きな表面積を持つことに着目した。基礎実験として安価なポリマー膜の吸着で調べたところ、モスアイ構造の適用で3倍程度、また微小球構造の適用で６倍程度感度を向上できた。また周囲の水溶液に近い屈折率を持つフッ素樹脂でナノ構造を作製することにより鋭い共鳴となり、高感度となることも明らかになった。本手法は多くのバイオセンサに適用でき、高感度化に寄与できると考える。

Research Products

• [Journal Article] Simultaneous detection of ammonia and humidity using transmission surface plasmon resonance technique (2019)
  • Author(s): Takano Tomohiro、Lertvachirapaiboon Chutiparn、Ohdaira Yasuo、Baba Akira、Shinbo Kazunari、Kato Keizo
  • Journal Title: Molecular Crystals and Liquid Crystals Volume: 685 Issue: 1 Pages: 93-99
  • DOI: 10.1080/15421406.2019.1645466
  • Peer Reviewed
• [Journal Article] Controlling the Luminescence of Gold Quantum Dots by the Plasmonic Effect of Silver Nanoprisms (2019)
  • Author(s): Lertvachirapaiboon Chutiparn、Kiyokawa Itaru、Baba Akira、Shinbo Kazunari、Kato Keizo
  • Journal Title: Plasmonics Volume: 15 Issue: 1 Pages: 3-9
  • DOI: 10.1007/s11468-019-01006-8
  • Peer Reviewed
• [Journal Article] Long-range Surface Plasmon Excitation and Photoisomerization of Azobenzene Dye (2018)
  • Author(s): Hiroshi Nakajo, Chutiparn Lertvachirapaiboon, Yasuo Ohdaira, Akira Baba, Keizo Kato, Futao Kaneko, and Kazunari Shinbo
  • Journal Title: Molecular Crystals and Liquid Crystals Volume: 660 Issue: 1 Pages: 156-162
  • DOI: 10.1080/15421406.2018.1456146
  • Peer Reviewed
• [Presentation] Surface Plasmon Transmission Light in Nanostructured Organic Thin Films on Metallic Gratings and Application to High-Sensitivity Sensors (2020)
  • Author(s): Keizo Kato, Chutiparn Lertvachirapaiboon, Akira Baba, Kazunari Shinbo
  • Organizer: 4th Japan-Thailand Joint Symposium on Advanced Nanomaterials and Devices for Electronics and Photonics
  • Int'l Joint Research
• [Presentation] Controlling the luminescent intensity of gold quantum dots by the plasmonic effect of silver nanoprisms (2020)
  • Author(s): Chutiparn Lertvachirapaiboon, Itaru Kiyokawa, Akira Baba, Kazunari Shinbo, Keizo Kato
  • Organizer: 4th Japan-Thailand Joint Symposium on Advanced Nanomaterials and Devices for Electronics and Photonics
  • Int'l Joint Research
• [Presentation] Preparation and Characteristics of Phototransistor and Organic Solar Cell on Grating Structure (2020)
  • Author(s): Kazunari Shinbo, Akira Baba, Keizo Kato
  • Organizer: 4th Japan-Thailand Joint Symposium on Advanced Nanomaterials and Devices for Electronics and Photonics
  • Int'l Joint Research
• [Presentation] モスアイ/金属構造の光学特性と光熱電変換への利用 (2020)
  • Author(s): 巻野 晋太郎，C. ラートバチラパイボーン，大平 泰生，馬場 暁，加藤 景三，新保 一成
  • Organizer: 第67回応用物理学会春季学術講演会
• [Presentation] Chemical mixture identification using transmission surface plasmon resonance based metallic grating sensor chip and pattern-recognition technique (2020)
  • Author(s): Chutiparn Lertvachirapaiboon, Akira Baba, Kazunari Shinbo, Keizo Kato
  • Organizer: The 67th Japan Society of Applied Physics Spring Meeting 2020
• [Presentation] 革新的高機能・高感度センサ開発と超高性能薄膜構造評価 (2020)
  • Author(s): 新保一成，ラートバチラパイボーン チュティパーン，馬場 暁，加藤 景三
  • Organizer: 令和2年電気学会全国大会
• [Presentation] QCM・T-SPR複合センサによるグリセリン水溶液の評価 (2019)
  • Author(s): 星井 歩夢 ，亀井 翼，ラートバチパイボ―ン ラートバチパイボ―ン ラートバチパイボ―ン チュティパ―ン チュティパ―ン ，大平 泰生 ，馬場 暁， 新保 一成 ，加藤 景三
  • Organizer: 令和元年度応用物理学会北陸・信越支部学術講演会
• [Presentation] Hybrid Sensors Using a Quartz Crystal Microbalance and Surface Plasmon Resonance for Evaluating Thin Film Structure and Liquid Properties (2019)
  • Author(s): Kazunari Shinbo, Chutiparn Lertvachirapaiboon, Yasuo Ohdaira, Akira Baba, Keizo Kato
  • Organizer: Asia Communications and Photonics Conference (ACP) 2019
  • Int'l Joint Research / Invited
• [Presentation] 水晶振動子および表面プラズモン共鳴を用いた複合センサの作製と薄膜・溶液評価 (2019)
  • Author(s): 新保一成，ラートバチラパイボーン チュティパーン，大平泰生，馬場 暁，加藤景三
  • Organizer: 令和元年電気学会基礎・材料・共通部門大会
• [Presentation] Fabrication of a quartz-crystal microbalance/ surface-plasmon-resonance hybrid sensor and taking advantage of their responses for evaluation of thin films and liquids (2019)
  • Author(s): Kazunari Shinbo, Chutiparn Lertvachirapaiboon, Yasuo Ohdaira, Akira Baba, Keizo Kato
  • Organizer: The 26th International Workshop on Active-Matrix Flatpanel Displays and Devices -TFT Technologies and FPD Materials-
  • Int'l Joint Research / Invited
• [Presentation] Transmission Light and Photoisomerization of Azobenzene Dye Induced by Long-Range Surface Plasmon Excitation (2018)
  • Author(s): Kazunari SHINBO, Hiroshi NAKAJO, Naoki OBATA, Yasuo OHDAIRA, Akira BABA, Keizo KATO
  • Organizer: 3rd Japan-Thailand Joint Symposium on Advanced Nanomaterials and Devices for Electronics and Photonics (JT-AND 2018)
  • Int'l Joint Research
• [Presentation] Simultaneous observation of ammonia and humidity using transmission surface plasmon resonance technique (2018)
  • Author(s): Tomohiro Takano, Yasuo ohdaira, Akira Baba, Kazunari Shinbo* and Keizo Kato
  • Organizer: 2018 KJF International Conference on Organic Materials for Electronics and Photonics
  • Int'l Joint Research
• [Presentation] Optical Properties of Vacuum Evaporated Metal Films on Moth-Eye Structure (2017)
  • Author(s): Kazunari Shinbo, Yu Tsumura, Chutiparn Lertvachirapaiboon, Yasuo Ohdaira, Akira Baba, Keizo Kato, Futao Kaneko
  • Organizer: The 6th International Symposium on Organic and Inorganic Electronic Materials and Related Nanotechnologies
• [Presentation] Photoisomerization of azobenzene dye and transmission long-range surface plasmon resonance properties (2017)
  • Author(s): Hiroshi Nakajo, Chutiparn Lertvachirapaiboon, Yasuo Ohdaira, Akira Baba, Kazunari Shinbo, Keizo Kato, and Futao Kaneko
  • Organizer: 9th International Conference on Molecular Electronics and Bioelectronics