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Research on highly-luminous, water-soluble dyes with rapid response against external environmental changes

Research Project

Project/Area Number 17K06850
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Structural/Functional materials
Research InstitutionNational Institute for Materials Science

Principal Investigator

ISAGO Hiroaki  国立研究開発法人物質・材料研究機構, エネルギー・環境材料研究拠点, 主幹研究員 (40343850)

Project Period (FY) 2017-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords分子スイッチ / 蛍光プローブ / 化学プローブ / フタロシアニン / 水溶性 / 高原子価銀 / リン / 水溶性フタロシアニン / 分子イメージング / 蛍光 / バイオイメージング / 発光 / amphoteric / 機能材料 / 合成化学 / 光物性 / バイオセンサー / 機能性色素
Outline of Final Research Achievements

Noble water-soluble chemical probes that emit deep-red/near-infrared light (650-900 nm) with high brightness (the product of molar extinction constant and fluorescence quantum yield) in response to external stimuli have been developed to engage deep-tissue molecular imaging. This study has elucidated the following findings. Firstly, a phosphorous-phthalocyanine complex rapidly pH-responsive that reversibly changes its fluorescence characteristics (the optical emission looks disappeared under acidic conditions) has been synthesized. Secondly, water-soluble phthalocyanine complexes of silver in a high oxidation state (+2) emit intense red fluorescence upon rapid and quantitative reaction with biothiols such as cysteine and glutathione.

Academic Significance and Societal Importance of the Research Achievements

当該研究成果の意義は、外部環境に応じて速やかに発光或いは発光/消光する水溶性フタロシアニン(Pc)色素を開発したことにある。本研究で取り扱ったPcは赤い蛍光(発光極大波長700nm付近)を発するため、生体の他の組織(筋肉・血液等)による吸収や発光に妨害を受けることが少なく、緑色光を用いるが故に小動物や表層組織に限られた従来のイメージングを大型動物や組織深部への発展を可能とし、チオールと迅速かつ定量的に反応する銀錯体やpHによって可逆的に発光・消光するリンの錯体は、アルツハイマー病の予防・治療や癌の蛍光診断の実現と普及に貢献すると期待される。

Report

(5 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (17 results)

All 2021 2020 2019 2018 2017

All Journal Article (6 results) (of which Peer Reviewed: 6 results,  Open Access: 1 results) Presentation (11 results) (of which Int'l Joint Research: 4 results,  Invited: 1 results)

  • [Journal Article] Spectral investigation of phthalocyanine complexes of high-valence silver and their aggregates2021

    • Author(s)
      Isago Hiroaki、Fujita Harumi、Nakai Suzuko、Sugimori Tamotsu
    • Journal Title

      Journal of Inorganic Biochemistry

      Volume: 219 Pages: 111427-111427

    • DOI

      10.1016/j.jinorgbio.2021.111427

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Syntheses of Water-Soluble Silver(II)-Phthalocyanines toward Optical Sensing for Thiol Detection2021

    • Author(s)
      Isago Hiroaki、Fujita Harumi、Nakai Suzuko、Sugimori Tamotsu
    • Journal Title

      Inorganic Chemistry

      Volume: 60 Issue: 9 Pages: 6739-6745

    • DOI

      10.1021/acs.inorgchem.1c00567

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Soft chromophore featured liquid porphyrins and their utilization toward liquid electret applications2019

    • Author(s)
      Ghosh Avijit、Yoshida Manabu、Suemori Kouji、Isago Hiroaki、Kobayashi Nagao、Mizutani Yasuhisa、Kurashige Yuki、Kawamura Izuru、Nirei Masami、Yamamuro Osamu、Takaya Tomohisa、Iwata Koichi、Saeki Akinori、Nagura Kazuhiko、Ishihara Shinsuke、Nakanishi Takashi
    • Journal Title

      Nature Communications

      Volume: 10 Issue: 1 Pages: 1-9

    • DOI

      10.1038/s41467-019-12249-8

    • NAID

      120006898089

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Amphoteric phosphorous(V)-phthalocyanines as proton-driven switchable fluorescers toward deep-tissue bio-imaging2018

    • Author(s)
      Isago Hiroaki、Fujita Harumi、Sugimori Tamotsu
    • Journal Title

      Journal of Inorganic Biochemistry

      Volume: 180 Pages: 222-229

    • DOI

      10.1016/j.jinorgbio.2017.12.014

    • Related Report
      2018 Research-status Report 2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Solvent effects on molecular aggregation of highl ywater-soluble phthalocyanines2018

    • Author(s)
      Hiroaki Isago, Harumi Fujita
    • Journal Title

      Journal of Porphyrins and Phthalocyanines

      Volume: 22 Issue: 01n03 Pages: 102-111

    • DOI

      10.1142/s1088424618500141

    • Related Report
      2018 Research-status Report 2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Observation of the First Spin Crossover in an Iron(II) Complex with an S6 Coordination Environment: Tris[bis(N,N-diethylamino)carbeniumdithiocarboxylato]iron(II) Hexafluorophosphate2018

    • Author(s)
      Sugaya Tomoaki、Fujihara Takashi、Naka Takashi、Furubayashi Takao、Matsushita Akiyuki、Isago Hiroaki、Nagasawa Akira
    • Journal Title

      Chemistry A European Journal

      Volume: 24 Issue: 68 Pages: 17955-17963

    • DOI

      10.1002/chem.201803330

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Presentation] Water-soluble Silver(II)-Phthalocyanines toward Fluorescence Sensing of Biothiols. Part 22021

    • Author(s)
      Hiroaki Isago, Harumi Fujita, Suzuko Nakai, Tamotsu Sugimori
    • Organizer
      日本化学会第101回春季年会
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Water-soluble Silver(II)-Phthalocyanines toward Fluorescence Sensing of Biothiols2020

    • Author(s)
      Hiroaki Isago, Harumi Fujita, Tamotsu Sugimori
    • Organizer
      錯体化学会第70回討論会
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Syntheses and spectral investigation of water-soluble silver(II)-phthalocyanine complexes2020

    • Author(s)
      Hiroaki Isago, Harumi Fujita, Tamotsu Sugimori
    • Organizer
      日本化学会第100春季年会
    • Related Report
      2019 Research-status Report
  • [Presentation] Syntheses and Spectral Investigation of Phthalocyanine Complexes of Silver in Higher Oxidation States2019

    • Author(s)
      Hiroaki Isago, Harumi Fujita, Suzuko Nakai, and Tamotsu Sugimori
    • Organizer
      第69回錯体化学討論会
    • Related Report
      2019 Research-status Report
  • [Presentation] Spectral Investigation of Phthalocyanine Complexes of High-Valence Silver and their Aggregates2019

    • Author(s)
      Hiroaki Isago, Harumi Fujita, Suzuko Nakai, and Tamotsu Sugimori
    • Organizer
      CEMS International Symposium on Supramolecular Chemistry and Functional Materials
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] 銀フタロシアニン錯体の酸化ならびに生成物の分光学的性質2019

    • Author(s)
      砂金宏明,藤田晴美,杉森保
    • Organizer
      日本化学会年会
    • Related Report
      2018 Research-status Report
  • [Presentation] スメクタイトに吸着した銀フタロシアニン錯体の水溶液中における分光学的性質2019

    • Author(s)
      砂金宏明,藤田晴美,杉森保
    • Organizer
      日本化学会年会
    • Related Report
      2018 Research-status Report
  • [Presentation] Study on syntheses of silver(II)-phthalocyanines and effects of molecular aggregation on their spectral properties2018

    • Author(s)
      H. Isago, H. Fujita, T. Sugimori
    • Organizer
      日本化学会年会
    • Related Report
      2018 Research-status Report
  • [Presentation] Study on Syntheses of Silver(II)-Phthalocyanines and Effects of Molecular Aggregation on their Spectral Properties2018

    • Author(s)
      砂金宏明、藤田晴美、中居寿々子、杉森保
    • Organizer
      日本化学会年会
    • Related Report
      2017 Research-status Report
  • [Presentation] Phosphorous-Phthalocyanines as Amphoteric Phosphors2017

    • Author(s)
      Hiroaki Isago, Harumi Fujita, Tamotsu Sugimori
    • Organizer
      6th Georgian Bay International Conference on Bioinorganic Chemistry
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 三価アンチモン-フタロシアニン錯体と銀塩の反応2017

    • Author(s)
      砂金宏明、藤田晴美、杉森保
    • Organizer
      錯体化学討論会
    • Related Report
      2017 Research-status Report

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Published: 2017-04-28   Modified: 2022-01-27  

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