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Development of decellularized medical materials for the anti-allergic agent search system in tissue engineering

Research Project

Project/Area Number 17K06899
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Properties in chemical engineering process/Transfer operation/Unit operation
Research InstitutionFukuoka University

Principal Investigator

MISHIMA KENJI  福岡大学, 工学部, 教授 (40190623)

Co-Investigator(Kenkyū-buntansha) シャーミン タンジナ  福岡大学, 工学部, 助教 (00794182)
井上 俊孝  西九州大学, 健康福祉学部, 教授 (20274615)
志村 英生  福岡大学, 医学部, 教授 (80178996)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2018: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2017: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Keywords超臨界流体 / 二酸化炭素 / 超音波 / 再生医療 / 化学工学 / 生体材料 / 反応・分離工学 / ナノ材料
Outline of Final Research Achievements

This is a study to decellularize organs and reconstruct the structural information of the extracellular matrix in order to create decellularized medical materials that can be used for the anti-allergic agent search system in tissue engineering. The implication of these antiallergic agents varied greatly depending on the individual, and there is a demand for regenerative medicine. There is a separate "model organ that reflects biological characteristics" that replaces drug testing, which places a heavy burden on patients. As a regenerative medical material, a cell-removed extracellular matrix derived from a living body is suitable for a scaffold for cell proliferation. We have developed a method for producing bioscaffold organs decellularized from organs of different mammals such as, pigs, etc. by using ultrasonic waves together with supercritical carbon dioxide, which is harmless to the living body and whose solvent properties are easy to control.

Academic Significance and Societal Importance of the Research Achievements

本研究は、脱化石資源が求められる国際社会で、高齢化社会における持続可能な高度技術を利用した高付加価値製品生産の基盤技術の創製である。生体に害がなく溶媒特性の制御が容易である超臨界二酸化炭素と超音波を併用し、生体複合材料調整に係わるナノ構造制御技術として、超臨界ナノ制御、ナノバブル、ナノ界面制御技術を開発した。従来の技術では、実用製品の機能・価格競争力の証明が課題となっている。本研究では、その課題解決策として、二酸化炭素と水が作り出すナノサイズの気液界面により、ナノメートルオーダーの微細構造制御を容易にし、有機溶媒を使用せず、安価で高機能性材料の創製を可能にする装置技術を提供した。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (101 results)

All 2020 2019 2018 2017

All Journal Article (39 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 27 results) Presentation (53 results) (of which Int'l Joint Research: 7 results,  Invited: 3 results) Patent(Industrial Property Rights) (9 results)

  • [Journal Article] Rapid Production of Liposomes Using High Pressure Carbon Dioxide and Direct Ultrasonication2020

    • Author(s)
      Shinichi Tokunaga, Hiroyuki Tashiro, Kento Ono, Tanjina Sharmin, Takafumi Kato, Keiichi Irie, Kenichi Mishima, Tomomitsu Satho, Taku M. Aida, Kenji Mishima,
    • Journal Title

      J. Supercritical Fluids

      Volume: 160 Pages: 104782-104782

    • DOI

      10.1016/j.supflu.2020.104782

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Extraction of Nobiletin and Tangeretin with Antioxidant Activity from Peels of Citrus Poonensis Using Liquid Carbon Dioxide and Ethanol Entrainer2020

    • Author(s)
      Ryunosuke Mitani, Hiroyuki Tashiro, Eito Arita, Kento Ono, Masashi Haraguchi, Shinichi Tokunaga, Tanjina Sharmin, Taku M. Aida, Kenji Mishima
    • Journal Title

      Sep. Sci. Technol

      Volume: - Issue: 2 Pages: 290-300

    • DOI

      10.1080/01496395.2020.1713813

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Generation of High Concentration Ultra-Fine Bubbles Using High Pressure Gas-Water Two-Phase System2019

    • Author(s)
      yunosuke Mitani, Kenji Mishima, Taku M. Aida, Tanjina Sharmin, Miyuki Nakamura
    • Journal Title

      The 32nd International Symposium on Chemical Engineering (ISChE 2019)

      Volume: -

    • Related Report
      2019 Annual Research Report
  • [Journal Article] Production of Liposomes Using Microphase Separation by Direct Ultrasonic Irradiation in Water-Liquid Carbon Dioxide System2019

    • Author(s)
      Hiroyuki Tashiro, Kenji Mishima, Taku M. Aida, Tanjina Sharmin, Shinichi Tokunaga, Miyuki Nakamura
    • Journal Title

      Proceedings of the 32nd International Symposium on Chemical Engineering (ISChE 2019)

      Volume: -

    • Related Report
      2019 Annual Research Report
  • [Journal Article] Reactions of Extracellular Matrix Biomaterials and Their Reaction Kinetics Under Hydrothermal Conditions2019

    • Author(s)
      Kento Ono, Shunsuke Matsunaga, Shinichi Tokunaga, Tanjina Sharmin, Miyuki Nakamura, Taku M. Aida, Kenji Mishima
    • Journal Title

      Proceedings of the 32nd International Symposium on Chemical Engineering (ISChE 2019)

      Volume: -

    • Related Report
      2019 Annual Research Report
  • [Journal Article] Preparation of Microcapsules Coated with Enteric Polymers by Particles from Gas Saturated Solution (PGSS) Method2019

    • Author(s)
      Shinichi Tokunaga, Kenji Mishima, Tanjina Sharmin, Taku M. Aida, Miyuki Nakamura
    • Journal Title

      Proceedings of the 32nd International Symposium on Chemical Engineering (ISChE 2019)

      Volume: -

    • Related Report
      2019 Annual Research Report
  • [Journal Article] Comparison of Ultrasonically Assisted Liquid CO2 Extraction of Mangiferin from Mangifera indica L. Seeds and Peels2019

    • Author(s)
      Wakana Ito, Taku M. Aida, Tanjina Sharmin, Miyuki Nakamura, Kenji Mishima
    • Journal Title

      Proceedings of the 32nd International Symposium on Chemical Engineering (ISChE 2019

      Volume: -

    • Related Report
      2019 Annual Research Report
  • [Journal Article] Extraction of Crocin from Gardenia Jasminoides Ellis Using Ultrasound and Liquid Carbon Dioxide2019

    • Author(s)
      Hiroki Sakai, Kenji Mishima, Taku M. Aida, Tanjina Sharmin, Miyuki Nakamura
    • Journal Title

      Proceedings of the 32nd International Symposium on Chemical Engineering (ISChE 2019

      Volume: -

    • Related Report
      2019 Annual Research Report
  • [Journal Article] Microcoating of Drugs with Enteric Polymers Using High Pressure Technology2019

    • Author(s)
      Shinichi Tokunaga, Kenji Mishima, Taku M. Aida, Tanjina Sharmin, Miyuki Nakamura
    • Journal Title

      Proceedings of the 4th Conference of Asia-Pacific Undersea & Hyperbaric Medical Society (APUHMS) in Nakatsu

      Volume: - Pages: 121-121

    • Related Report
      2019 Annual Research Report
  • [Journal Article] Application of Medical Materials with Using High Pressure Technology2019

    • Author(s)
      Hiroyuki Tashiro, Ryunosuke Mitani, Taku M. Aida, Tanjina Sharmin, Kenji Mishima
    • Journal Title

      Proceedings of the 4th Conference of Asia-Pacific Undersea & Hyperbaric Medical Society (APUHMS) in Nakatsu

      Volume: - Pages: 42-42

    • Related Report
      2019 Annual Research Report
  • [Journal Article] Modified Gas-Saturated Solution Process for Masking Microcomposite Particles of Alpha Lipoicacid/Hydrogenated Colza Oil in Supercritical Carbon Dioxide2019

    • Author(s)
      Eito Arita, Tanjina Sharmin, Taku M. Aida, Miyuki Nakamura, Kenji Mishima
    • Journal Title

      Proceedings of the 4th Conference of Asia-Pacific Undersea & Hyperbaric Medical Society (APUHMS) in Nakatsu

      Volume: - Pages: 10-10

    • Related Report
      2019 Annual Research Report
  • [Journal Article] Decomposition of Biocompatible Polymer in High Temperature Water2019

    • Author(s)
      Taku M. Aida, Minori Oshima, Richard Lee SMITH Jr., Shunsuke Matsunaga, Kento Ono, Shinichi Tokunaga, Tanjina Sharmin, Kenji Mishima
    • Journal Title

      Proceedings of the 18th Asisan Pacific Confederation of Chemical Engineering Congress (APCChE 2019)

      Volume: - Pages: 157-157

    • Related Report
      2019 Annual Research Report
  • [Journal Article] Control of Interface of Micro- and Nano-Composite Particles and Bubbles by High Pressure Technique2019

    • Author(s)
      Shinichi Tokunaga, Tanjina Sharmin, Taku AIDA, Kenji Mishima
    • Journal Title

      Proceedings of the 18th Asisan Pacific Confederation of Chemical Engineering Congress (APCChE 2019)

      Volume: - Pages: 184-184

    • Related Report
      2019 Annual Research Report
  • [Journal Article] Characterization and pharmacokinetic evaluation of microcomposite particles of alpha lipoic acid/hydrogenated colza oil obtained in supercritical carbon dioxide2019

    • Author(s)
      Honjo Masatoshi、Yasuhide Okuhara、Yamada Masayoshi、Higuchi Sei、Mishima Kenji、Tanjina Sharmin、Aida Taku Michael、Kato Takafumi、Misumi Makoto、Suetsugu Tadashi、Orii Hideaki、Irie Keiichi、Sano Kazunori、Mishima Kenichi、Satho Tomomitsu、Harada Takunori
    • Journal Title

      Pharmaceutical Development and Technology

      Volume: 11 Issue: 3 Pages: 1-29

    • DOI

      10.1080/10837450.2019.1567760

    • Related Report
      2019 Annual Research Report 2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] The role of chemical engineering in the application process of carbon dioxide2018

    • Author(s)
      Kenji MISHIMA
    • Journal Title

      Proc. on International Meeting On Collaboration Technologies 2018 (IMCT2018)

      Volume: - Pages: 23-23

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Development of automatic phase separation recognition method by image processing2018

    • Author(s)
      Eito Arita, Daiki Nakamura, Makoto Misumi, Hideaki Orii, Kenji Mishima, Tanjina Sharmin, Taku M. Aida, Miyuki Nakamura
    • Journal Title

      Proceedings of the 8th International Symposium on Molecular Thermodynamics and Molecular Simulation(MTMS’18)

      Volume: - Pages: 133-133

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Novel method for Screening hypertension suppressing substance from soybean milk protein2018

    • Author(s)
      Ryunosuke Mitani, Kenji Mishima, Tanjina Sharmin, Taku M. AIDA, Miyuki Nakamura
    • Journal Title

      Proceedings of the 8th International Symposium on Molecular Thermodynamics and Molecular Simulation(MTMS’18)

      Volume: - Pages: 93-93

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Encapsulation of silica hollow microspheres with pH responsive polymer by pressureinduced phase separation of CO2 Solution2018

    • Author(s)
      Kento Ono, Shinichi Tokunaga, Kenji Mishima, Tanjina Sharmin, Taku Aida, Miyuki Nakamura
    • Journal Title

      Proceedings of the 8th International Symposium on Molecular Thermodynamics and Molecular Simulation(MTMS’18)

      Volume: - Pages: 127-127

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Antioxidant activity of nobiletin and tangeretin extracted from Genkou peels by optimized liquid carbon dioxide2018

    • Author(s)
      Hiroyuki Tashiro, Ryunosuke Mitani, Shinichi Tokunaga, Masashi Haraguchi, Kenji Mishima, Tanjina Sharmin, Taku Michael Aida, Miyuki Nakamura
    • Journal Title

      Proceedings of the 8th International Symposium on Molecular Thermodynamics and Molecular Simulation(MTMS’18)

      Volume: - Pages: 108-108

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Measuring the Effects of Citrus Fruits on Cerebral blood flow by using fNIRS2018

    • Author(s)
      Masashi Haraguchi, Kenji Mishima, Taku M. Aida, Tanjina Sharmin, Miyuki Nakamura, Hiroyuki Tashiro
    • Journal Title

      Proceedings of the 8th International Symposium on Molecular Thermodynamics and Molecular Simulation(MTMS’18)

      Volume: - Pages: 119-119

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] pH-responsive polymer microcoating of drug by PGSS method using supercritical CO22018

    • Author(s)
      Shinichi Tokunaga, Kenji Mishima, Tanjina Sharimin, Taku Michael Aida, Miyuki Nakamura
    • Journal Title

      Proceedings of the 8th International Symposium on Molecular Thermodynamics and Molecular Simulation(MTMS’18)

      Volume: - Pages: 121-121

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Supercritical Fluid Technology in Pharmaceutical Research2018

    • Author(s)
      Kenji MISHIMA
    • Journal Title

      Proc. the 4th International Pharmaceutical Research Conference, Malaysia (4thiPRC’18)

      Volume: - Pages: 14-14

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Production of Nano-devices for cancer therapy using ultra sonication in liquid carbon dioxide2018

    • Author(s)
      Eito Arita, Kenji Mishima, Tanjina Sharmin, Taku M. Aida, Miyuki Nakamura
    • Journal Title

      Proceedings of the 15th International Symposium on Functionally Graded Materials (ISFGMs 2018)

      Volume: - Pages: 140-140

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Production of liposome using ultrasonic irradiation and high pressure cell2018

    • Author(s)
      Hiroyuki Tashiro, Kenji Mishima, Taku M. Aida, Tanjina Sharimin, Miyuki Nakamura
    • Journal Title

      Proceedings of the 15th International Symposium on Functionally Graded Materials (ISFGMs 2018)

      Volume: - Pages: 142-142

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Microencapsulation of drugs with pH-responsive polymer for controlled release of drug by PGSS process of CO22018

    • Author(s)
      Ryunosuke Mitani, Kenji Mishima, Tanjina Sharimin, Taku M. Aida, Miyuki Nakamura
    • Journal Title

      Proceedings of the 15th International Symposium on Functionally Graded Materials (ISFGMs 2018)

      Volume: - Pages: 141-141

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Preparation of Microcapsules coated with Styrene-modified CNF using Supercritical Carbon dioxide2018

    • Author(s)
      Shinichi Tokunaga, Kenji Mishima, Taku M. Aida, Tanjina Sharmin, Miyuki Nnakamura
    • Journal Title

      Proceedings of the 15th International Symposium on Functionally Graded Materials (ISFGMs 2018)

      Volume: - Pages: 73-73

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] デジタルイメージプロセッシングによる水性二相系分離挙動の認識2018

    • Author(s)
      三島健司、Tanjina SHARMIN、相田卓、三角真、折居英章
    • Journal Title

      福岡大学工学集報

      Volume: - Pages: 23-26

    • NAID

      120006619950

    • Related Report
      2018 Research-status Report
  • [Journal Article] .Bringing Research to Industry Environmentally Benign Supercritical Fluid Technology for Nano and Micro Composite Materials,2018

    • Author(s)
      K. Mishima
    • Journal Title

      Proceedings of Inteanational Symposium of Science and Technology For Better Future

      Volume: 1 Pages: 20-20

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Basic Spectroscopic Study for Effect of Alubumin for Drug Delivery System,2017

    • Author(s)
      M. Haraguchi, S. Tokunaga, S. Ito, K. Mishima, T. Sharmin, M. Nakamura, T. Kato, M. Misumi, T. Suetsugu, H. Orii, T. Harada
    • Journal Title

      Proceedings of the 15th Korea / Japan International Symposium on Resources Recycling and Materials Science, 2017

      Volume: 1 Pages: 281-281

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effective Utilization of CO2 in Manufacturing pH-Responsive Microparticle,2017

    • Author(s)
      S. Tokunaga, M. Haraguchi, S. Ito, K. Mishima, T. Sharmin, M. Nakamura, T. Kato, M. Misumi, T. Suetsugu, H. Orii, T. Harada,
    • Journal Title

      Proceedings of the 15th Korea / Japan International Symposium on Resources Recycling and Materials Science, 2017

      Volume: 1 Pages: 283-283

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Novel Production Method of pH-Responsive Microcapsules for DDS2017

    • Author(s)
      S. Tokunaga, M. Haraguchi, S. Ito, K. Mishima, T. Sharmin, M. Nakamura, T. Kato, M. Misumi, T. Suetsugu, H. Orii, T. Harada,
    • Journal Title

      Proceedings of the 7th Asian Particle Technology Symposium (Chang Gung University,Taiwan)

      Volume: 1 Pages: 115-120

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Production of pH-responsive composite microcapsules and sustained release rate2017

    • Author(s)
      S.Tokunaga, M. Haraguchi, S. Ito, K. Mishima, T. Sharmin, Mi. Nakamura, T. Kato, M. Misumi, T. Suetsugu, H. Orii, T. Harada
    • Journal Title

      Proceedings of the 5th International Symposium & Exhibition on Aqua Science and Water Resources (ISASWR’17)

      Volume: 1 Pages: 173-178

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Ethanol modified liquid carbon dioxide extraction of nobiletin and tangeretin with antioxidant activity from peels of Citrus poonensis2017

    • Author(s)
      R. Mitani, S. Tokunaga, M. Haraguchi, K. Mishima, T. Sharmin, M. Nakamura, Takafumi Kato, M. Misumi, T. Suetsugu, H. Orii, K. Irie, T. Satho, T. Harada
    • Journal Title

      Proceedings of the 5th International Symposium & Exhibition on Aqua Science and Water Resources (ISASWR’17)

      Volume: 1 Pages: 258-261

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Coacervation Microencapsulation of Particles with Polymer by Pressure-induced Phase Separation of Supercritical Carbon Dioxide Solutions2017

    • Author(s)
      K. Mishima
    • Journal Title

      Proceedings of the 5th International Symposium & Exhibition on Aqua Science and Water Resources (ISASWR’17)

      Volume: 1 Pages: 34-34

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] .Microcoating of Silica Hollow Microsphers with Polymer by Pressure-Induced Phase Separation of CO2 Solution2017

    • Author(s)
      Kenton Ono, K. Mishima, T. Sharmin, M. Nakamura
    • Journal Title

      Proceedings of the 5th International Symposium & Exhibition on Aqua Science and Water Resources (ISASWR’17)

      Volume: 1 Pages: 188-191

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effects of Smell of the Citrus Fruit Peel Fragrance on Cerebral Blood Oxygenation during Relaxation Measured by fNIRS2017

    • Author(s)
      H. Tasiro, E. Arita, K. Mishima, T. Sharmin, M. Nakamura
    • Journal Title

      Proceedings of the 5th International Symposium & Exhibition on Aqua Science and Water Resources (ISASWR’17)

      Volume: 1 Pages: 183-187

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Screening of Angiotensin Converting Enzyme (ACE) Inhibitor from Soybean Milk Protein Hydrolysate by Means of Synthesized Fluorescent Peptide Substrates,2017

    • Author(s)
      E. Arita, H. Tashiro, K. Mishima, T. Sharmin, M. Nakamura
    • Journal Title

      Proceedings of the 5th International Symposium & Exhibition on Aqua Science and Water Resources (ISASWR’17)

      Volume: 1 Pages: 179-182

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Simultaneous Determination of Chloride, Lactate and Acetate in Pharmaceuticals Formulations by HPLC Method Considering Green Analytical Chemistry Concept,2017

    • Author(s)
      T. Parimal, K. Mishima, T. Sharmin,
    • Journal Title

      Proceedings of the 5th International Symposium & Exhibition on Aqua Science and Water Resources (ISASWR’17)

      Volume: 1 Pages: 94-94

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Formation of Functional Microcapsules Using Pressure-Induced Phase Separation of CO2 Solution,2017

    • Author(s)
      K. Mishima, S. Tokunaga, M. Haraguchi, T. Sharmin, M. Nakamura, T. Kato, M. Misumi, T. Suetsugu, H. Orii, T. Harada
    • Journal Title

      Proceedings of the 17th Congress, Asian Pacific Confederation of Chemical Engineering(APPCE)

      Volume: 1 Pages: 78-78

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Presentation] 超臨界流体技術の医療・医薬・化粧品・食品への応用2020

    • Author(s)
      三島健司
    • Organizer
      第28回超臨界流体委員会~超臨界流体を用いた応用技術
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 【依頼講演】高温高圧水および高圧二酸化炭素を用いた生体材料の調製2020

    • Author(s)
      相田 卓・シャーミン タンジナ・三島健司・スミス リチャード
    • Organizer
      化学工学会第85年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] SFEE法を用いた機能性ナノカプセルの調製2020

    • Author(s)
      徳永真一・シャーミンタンジナ・相田卓・三島健司
    • Organizer
      化学工学会第85年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 生分解性高分子によるマイクロコーティング2020

    • Author(s)
      伊藤 稚菜、田代 裕之、堺 洸稀、シャーミンタンジナ、相田 卓、三島健司
    • Organizer
      化学工学会第85年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] pH応答性高分子を用いた乳酸菌のマイクロカプセル製造2020

    • Author(s)
      堺洸稀、有田栄人、相田卓、シャーミンタンジナ、中村美由紀、三島健司
    • Organizer
      化学工学会第85年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Development of Rapidly Preparation for Drug-Encapsulated Liposomes2020

    • Author(s)
      Shinichi Tokunaga, Tanjina Sharmin, Taku M. Aida, Kenji Mishima
    • Organizer
      International Chemical Engineering Symposia 2020 (IChES 2020)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Rosmarinic Acid Extraction Using Ultra-Fine Bubbles from Perilla Frutescens Leaves2019

    • Author(s)
      Ryunosuke Mitani, Kenji Mishima, Taku M. Aida, Tanjina Sharmin, Miyuki Nakamura
    • Organizer
      2019 Japan/Taiwan/Korea Chemical Engineering Conference(2019, 11)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effects of Ultrasonication on the Production of Drug-Encapsulated Liposomes in Liquid Carbon Dioxide2019

    • Author(s)
      Hiroyuki Tashiro, Kenji Mishima, Taku M. Aida, Tanjina Sharmin, Shinichi Tokunaga, Miyuki Nakamura
    • Organizer
      2019 Japan/Taiwan/Korea Chemical Engineering Conference(2019, 11)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Enteric Polymer Encapsulation and Survival of Probiotic Bacteria Using W/O Emulsion Method2019

    • Author(s)
      Eito Arita, Tanjina Sharmin, Taku AIDA, Miyuki Nakamura, Yukihiko NAKASHIMA, Kenji Mishima
    • Organizer
      2019 Japan/Taiwan/Korea Chemical Engineering Conference(2019, 11)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effects of Surfactants on The Formation of Liposomes2019

    • Author(s)
      Wakana ITO, Taku M. Aida, Tanjina Sharmin, Miyuki Nakamura, Kenji Mishima
    • Organizer
      2019 Japan/Taiwan/Korea Chemical Engineering Conference(2019, 11)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A Green Extraction Method for Crocin Extraction from Gardenia Jasminoides Ellis Using Liquid Carbon Dioxide2019

    • Author(s)
      Hiroki SAKAI, Kenji Mishima, Taku M. Aida, Tanjina Sharmin, Miyuki Nakamura
    • Organizer
      2019 Japan/Taiwan/Korea Chemical Engineering Conference(2019, 11)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Preparation of DSPE-PEG Modified Liposomes with Ultrasonication2019

    • Author(s)
      Shinichi Tokunaga, Aida M. TAKU, Tanjina Sharmin, Miyuki Nakamura, Kenji Mishima
    • Organizer
      2019 Japan/Taiwan/Korea Chemical Engineering Conference (2019, 11)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 液体二酸化炭素を用いたマンゴー果皮からの抗酸化物質の抽出2019

    • Author(s)
      伊藤 稚菜、相田 卓、シャーミン タンジナ、中村 美由紀、三島健司
    • Organizer
      第38回溶媒抽出討論会
    • Related Report
      2019 Annual Research Report
  • [Presentation] エタノールと液体二酸化炭素によるクチナシの果実から天然色素の抽出2019

    • Author(s)
      堺 洸稀、三島健司、相田 卓、シャーミン タンジナ、中村 美由紀
    • Organizer
      第38回溶媒抽出討論会
    • Related Report
      2019 Annual Research Report
  • [Presentation] ロスマリン酸抽出率に及ぼすCO2ウルトラファインバブル濃度の効果2019

    • Author(s)
      三谷龍之介、三島健司、相田卓、シャーミン タンジナ、中村美由紀
    • Organizer
      第38回溶媒抽出討論会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 超音波照射併用液体二酸化炭素抽出率に及ぼす被抽出物構造の効果2019

    • Author(s)
      田代裕之、三谷龍之介、三島健司、相田卓、シャーミン・タンジナ
    • Organizer
      第38回溶媒抽出討論会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 光線免疫療法のためのSFEE法を用いたナノカプセルの開発2019

    • Author(s)
      三谷 龍之介、田代 裕之、三島健司、相田 卓、シャーミン タンジナ、中村 美由紀
    • Organizer
      2019年度秋期研究発表会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 超臨界二酸化炭素を用いたCNFを被膜物質としたマイクロカプセルの開発2019

    • Author(s)
      田代 裕之、 三島健司、 相田 卓、 シャーミン タンジナ、 中村 美由紀
    • Organizer
      2019年度秋期研究発表会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 超音波照射による高濃度マイクロ・ナノバブル水の新規製造技術2019

    • Author(s)
      徳永真一、三谷龍之介、三島健司、相田 卓、シャーミン タンジナ、中村美由紀
    • Organizer
      日本混相流学会 混相流シンポジウム2019
    • Related Report
      2019 Annual Research Report
  • [Presentation] ナノバブル水を用いたロスマリン酸の抽出2019

    • Author(s)
      小野堅登、三谷龍之介、田代裕之、有田栄人、三島健司、相田 卓、シャーミン タンジナ、中村美由紀
    • Organizer
      日本混相流学会 混相流シンポジウム2019
    • Related Report
      2019 Annual Research Report
  • [Presentation] 画像解析法によるバブル消失の自動認識2019

    • Author(s)
      伊藤 稚菜、堺 洸稀 、徳永 真一、相田 卓、シャーミン タンジナ、中村 美由紀、三島健司
    • Organizer
      日本混相流学会 混相流シンポジウム2019
    • Related Report
      2019 Annual Research Report
  • [Presentation] ウルトラファインバブルのシソ葉抽出に及ぼす効果2019

    • Author(s)
      三谷 龍之介、有田 栄人、伊藤 稚菜、相田 卓、シャーミン タンジナ、三島健司
    • Organizer
      分離技術会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 植物由来材料を用いたカプセルの形成2019

    • Author(s)
      徳永真一、河野利紀、三島健司、相田卓、シャーミンタンジナ、中村美由紀
    • Organizer
      第56回化学関連支部合同九州大会外国人研究者交流国際シンポジウム
    • Related Report
      2019 Annual Research Report
  • [Presentation] 高濃度ウルトラファインバブルの新規調整法とその応用2019

    • Author(s)
      三谷龍之介、秋山廉、三島健司、相田卓、シャーミン・タンジナ、中村美由紀
    • Organizer
      第56回化学関連支部合同九州大会外国人研究者交流国際シンポジウム
    • Related Report
      2019 Annual Research Report
  • [Presentation] 自吸式通気攪拌装置におけるナノバブルの発生と通常型との比較2019

    • Author(s)
      坂元俊介、徳永真一、三谷龍之介、三島健司、田代幸寛、酒井謙二
    • Organizer
      第56回化学関連支部合同九州大会外国人研究者交流国際シンポジウム
    • Related Report
      2019 Annual Research Report
  • [Presentation] 水-液体二酸化炭素系での超音波直接照射を用いたリポソームの製造2019

    • Author(s)
      田代裕之、榊原智紀、三島健司、シャーミン・タンジナ、相田卓、中村美由紀
    • Organizer
      第56回化学関連支部合同九州大会外国人研究者交流国際シンポジウム
    • Related Report
      2019 Annual Research Report
  • [Presentation] 腸内送達のためのLactobacillus casei S-1のpH応答性高分子マイクロコーティング2019

    • Author(s)
      有田栄人、野副桂右、三島健司、シャーミン・タンジナ、相田卓、中村美由紀
    • Organizer
      第56回化学関連支部合同九州大会外国人研究者交流国際シンポジウム
    • Related Report
      2019 Annual Research Report
  • [Presentation] レボフロキサシンの高分子マイクロコーティング法の開発2019

    • Author(s)
      小野堅登、柴田浩一朗、平野彰、三島健司、相田卓、シャーミン タンジナ、中村美由紀
    • Organizer
      第56回化学関連支部合同九州大会外国人研究者交流国際シンポジウム
    • Related Report
      2019 Annual Research Report
  • [Presentation] 細胞外マトリックスの熱水における分解反応2019

    • Author(s)
      伊藤 稚菜、相田 卓、松永 駿介、小野 堅登、シャーミン タンジナ、椎原 明希、由布 知弓、中村 美由紀、三島健司
    • Organizer
      第56回化学関連支部合同九州大会外国人研究者交流国際シンポジウム
    • Related Report
      2019 Annual Research Report
  • [Presentation] SFEE法を用いたフタロシアニン誘導体のナノコーティング2019

    • Author(s)
      堺洸稀、田尻雄大、三島健司、相田卓、シャーミンタンジナ、中村美由紀
    • Organizer
      第56回化学関連支部合同九州大会外国人研究者交流国際シンポジウム
    • Related Report
      2019 Annual Research Report
  • [Presentation] 液二酸化炭素中での超音波照射によるリポソームの調製2019

    • Author(s)
      田代 裕之,小野 堅登,徳永 真一,タンジナ シャーミン,相田 卓,三島 健司
    • Organizer
      化学工学会 第84回年会
    • Related Report
      2018 Research-status Report
  • [Presentation] マイクロ・ナノバブルを用いたシソ葉からの有用物質の抽出2019

    • Author(s)
      三谷 龍之介,有田 栄人,徳永 真一, タンジナ シャーミン,相田 卓,三島 健司
    • Organizer
      化学工学会 第84回年会
    • Related Report
      2018 Research-status Report
  • [Presentation] マイクロ・ナノバブルの高濃度化2018

    • Author(s)
      三島健司
    • Organizer
      第7回日本マイクロ・ナノバブル学会学術総会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 超音波を用いたCO2ナノバブルの調製と新規DDSの開発2018

    • Author(s)
      原口雅史,三島健司,徳永真一
    • Organizer
      第7回日本マイクロ・ナノバブル学会学術総会
    • Related Report
      2018 Research-status Report
  • [Presentation] 炭酸ガスナノバブルを用いた気液系でのリポソームの調製2018

    • Author(s)
      徳永真一,三島健司,原口雅史
    • Organizer
      第7回日本マイクロ・ナノバブル学会学術総会
    • Related Report
      2018 Research-status Report
  • [Presentation] 分離現象に対する画像認識評価の適応性2018

    • Author(s)
      有田栄人,三島健司,相田 卓,シャーミン タンジナ,中村美由紀,
    • Organizer
      化学工学会 第50回秋季大会
    • Related Report
      2018 Research-status Report
  • [Presentation] 有害な有機溶剤を用いないリポソーム調製2018

    • Author(s)
      田代裕之・三島健司・相田 卓,シャーミン タンジナ,中村美由紀
    • Organizer
      化学工学会 第50回秋季大会
    • Related Report
      2018 Research-status Report
  • [Presentation] アンジオテンシンI 変換酵素に対するペプチドの影響2018

    • Author(s)
      三谷龍之介,三島健司,相田 卓,シャーミン タンジナ,中村美由紀
    • Organizer
      化学工学会 第50回秋季大会
    • Related Report
      2018 Research-status Report
  • [Presentation] 超臨界二酸化炭素を用いたセルロースナノファイバーマイクロカプセルの生成2018

    • Author(s)
      徳永真一,三島健司,相田卓,シャーミン タンジナ,中村美由紀
    • Organizer
      化学工学会 第50回秋季大会
    • Related Report
      2018 Research-status Report
  • [Presentation] 画像認識法による自動相分離認識方法の開発2018

    • Author(s)
      有田栄人,山下翔平,三角真,折居英章,三島健司,シャーミン タンジナ,相田卓,中村美由紀
    • Organizer
      第55回化学関連支部合同九州大会外国人研究者交流国際シンポジウム
    • Related Report
      2018 Research-status Report
  • [Presentation] ジメチルエーテルを用いたDNAの抽出2018

    • Author(s)
      小野堅登,佐伯雄一郎,三島健司,相田卓,シャーミン タンジナ,中村美由紀,
    • Organizer
      第55回化学関連支部合同九州大会外国人研究者交流国際シンポジウム
    • Related Report
      2018 Research-status Report
  • [Presentation] 難水溶性薬剤の可溶化方法の開発2018

    • Author(s)
      田代裕之,西村優希,三島健司,相田卓,シャーミン タンジナ,中村美由紀
    • Organizer
      第55回化学関連支部合同九州大会外国人研究者交流国際シンポジウム
    • Related Report
      2018 Research-status Report
  • [Presentation] 大豆たんぱく質を用いた高血圧抑制成分の開発2018

    • Author(s)
      三谷龍之介,山田泰士,三島健司,相田卓,シャーミン タンジナ,中村美由紀
    • Organizer
      第55回化学関連支部合同九州大会外国人研究者交流国際シンポジウム
    • Related Report
      2018 Research-status Report
  • [Presentation] fNIRSによるリモネンが脳血流に与える効果の測定2018

    • Author(s)
      原口雅史,三島健司,シャーミン タンジナ,相田卓,田代裕之,中村美由紀
    • Organizer
      第55回化学関連支部合同九州大会外国人研究者交流国際シンポジウム
    • Related Report
      2018 Research-status Report
  • [Presentation] 超臨界二酸化炭素のPGSS法を用いたpH応答型マイクロカプセルの生成2018

    • Author(s)
      徳永真一,三島健司,相田卓,シャーミン タンジナ,中村美由紀,
    • Organizer
      第55回化学関連支部合同九州大会外国人研究者交流国際シンポジウム
    • Related Report
      2018 Research-status Report
  • [Presentation] 有害有機溶媒を用いないナノデバイス創製2018

    • Author(s)
      .三島健司
    • Organizer
      日本超音波医学会研究会平成29年度第4回超音波分子診断治療研究会
    • Related Report
      2017 Research-status Report
  • [Presentation] 22.機能性材料創製のための超臨界二酸化炭素を用いた分離技術・複合化技術2017

    • Author(s)
      .三島健司
    • Organizer
      分離技術会年会オープンイノベーション2017
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] 二酸化炭素溶液の圧力誘起分離を利用した薬剤のpH応答性高分子によるマイクロカプセル化2017

    • Author(s)
      徳永真一・原口雅史・伊藤祥太・三島健司・シャーミンタンジナ・加藤貴史・三角真・末次正・折居英章・原田拓典
    • Organizer
      第、54回化学関連支部合同九州大会外国人研究者交流国際シンポジウム
    • Related Report
      2017 Research-status Report
  • [Presentation] アピゲニンに対する牛血清アルブミの相互作用分光学的研究2017

    • Author(s)
      原口雅史・徳永真一・伊藤祥太・三島健司・シャーミンタンジナ・加藤貴史・三角真・末次正・折居英章・原田拓典・Hilyatuz Zahroh・Agus Salim
    • Organizer
      第54回化学関連支部合同九州大会外国人研究者交流国際シンポジウム
    • Related Report
      2017 Research-status Report
  • [Presentation] エタノール添加液体二酸化炭素によるポンカン果皮からのノビレチンならびにタンゲレチンの抽出2017

    • Author(s)
      三谷龍之介・徳永真一・原口雅史・三島健司・シャーミンタンジナ・中村美由紀・加藤貴史・三角真・末次正・折居英章・原田拓典
    • Organizer
      第54回化学関連支部合同九州大会外国人研究者交流国際シンポジウム
    • Related Report
      2017 Research-status Report
  • [Presentation] 超臨界二酸化炭素を用いた薬剤のpH応答性高分子によるマイクロコーティング2017

    • Author(s)
      徳永真一・シャーミンタンジナ・中村美由紀・三島健司
    • Organizer
      化学工学会 第49回秋季大会(2017,9)
    • Related Report
      2017 Research-status Report
  • [Presentation] イメージプロセッシングによる相分離挙動の認識2017

    • Author(s)
      三島健司・タンジナシャーミン・中村美由紀・中村大気・徳永真一・三谷龍之介・三角真
    • Organizer
      化学工学会金沢大会2017年
    • Related Report
      2017 Research-status Report
  • [Presentation] イメージプロセッシングによるマイクロバブル挙動の認識2017

    • Author(s)
      三島健司・タンジナシャーミン・中村美由紀・中村大気・徳永真一・三谷龍之介・三角真
    • Organizer
      日本マイクロナノバブル学会2017年度第6回学術総会
    • Related Report
      2017 Research-status Report
  • [Patent(Industrial Property Rights)] オゾンバブル水の製造方法およびそれを用いたオゾンバブル水製造装置2020

    • Inventor(s)
      三島 健司、徳永 真一、小野 堅登
    • Industrial Property Rights Holder
      三島 健司、徳永 真一、小野 堅登
    • Industrial Property Rights Type
      特許
    • Filing Date
      2020
    • Related Report
      2019 Annual Research Report
  • [Patent(Industrial Property Rights)] コーティング粒子の製造方法2020

    • Inventor(s)
      三島 健司、徳永 真一、小野 堅登
    • Industrial Property Rights Holder
      三島 健司、徳永 真一、小野 堅登
    • Industrial Property Rights Type
      特許
    • Filing Date
      2020
    • Related Report
      2019 Annual Research Report
  • [Patent(Industrial Property Rights)] マイクロカプセルの製造方法2020

    • Inventor(s)
      三島 健司、徳永 真一、小野 堅登
    • Industrial Property Rights Holder
      三島 健司、徳永 真一、小野 堅登
    • Industrial Property Rights Type
      特許
    • Filing Date
      2020
    • Related Report
      2019 Annual Research Report
  • [Patent(Industrial Property Rights)] セルロースナノファイバーカプセルの製造方法2020

    • Inventor(s)
      三島 健司、徳永 真一、小野 堅登
    • Industrial Property Rights Holder
      三島 健司、徳永 真一、小野 堅登
    • Industrial Property Rights Type
      特許
    • Filing Date
      2020
    • Related Report
      2019 Annual Research Report
  • [Patent(Industrial Property Rights)] マイクロ・ナノバブルの製造方法2018

    • Inventor(s)
      三島健司、相田卓、シャーミンタンジナ、徳永真一
    • Industrial Property Rights Holder
      三島健司、相田卓、シャーミンタンジナ、徳永真一
    • Industrial Property Rights Type
      特許
    • Filing Date
      2018
    • Related Report
      2018 Research-status Report
  • [Patent(Industrial Property Rights)] リポソームの製造方法2018

    • Inventor(s)
      三島健司、シャーミンタンジナ、徳永真一
    • Industrial Property Rights Holder
      三島健司、シャーミンタンジナ、徳永真一
    • Industrial Property Rights Type
      特許
    • Filing Date
      2018
    • Related Report
      2018 Research-status Report
  • [Patent(Industrial Property Rights)] セルロースナノファイバーを用いたマイクロカプセルおよび複合粒子ならびその製造方法2018

    • Inventor(s)
      三島健司、徳永真一
    • Industrial Property Rights Holder
      三島健司、徳永真一
    • Industrial Property Rights Type
      特許
    • Filing Date
      2018
    • Related Report
      2018 Research-status Report
  • [Patent(Industrial Property Rights)] セルロースナノファイバーを用いたマイクロカプセルおよび複合粒子ならびその製造方法2018

    • Inventor(s)
      三島健司、徳永真一
    • Industrial Property Rights Holder
      三島健司、徳永真一
    • Industrial Property Rights Type
      特許
    • Filing Date
      2018
    • Related Report
      2017 Research-status Report
  • [Patent(Industrial Property Rights)] リポソームの製造方法2018

    • Inventor(s)
      三島健司、シャーミン・タンジナ徳永真一
    • Industrial Property Rights Holder
      三島健司、シャーミン・タンジナ徳永真一
    • Industrial Property Rights Type
      特許
    • Filing Date
      2018
    • Related Report
      2017 Research-status Report

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Published: 2017-04-28   Modified: 2021-02-19  

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