Development of decellularized medical materials for the anti-allergic agent search system in tissue engineering
| Project/Area Number |
17K06899
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Properties in chemical engineering process/Transfer operation/Unit operation
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| Research Institution | Fukuoka University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
シャーミン タンジナ 福岡大学, 工学部, 助教 (00794182)
井上 俊孝 西九州大学, 健康福祉学部, 教授 (20274615)
志村 英生 福岡大学, 医学部, 教授 (80178996)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2018: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2017: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
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| Keywords | 超臨界流体 / 二酸化炭素 / 超音波 / 再生医療 / 化学工学 / 生体材料 / 反応・分離工学 / ナノ材料 |
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| Outline of Final Research Achievements |
This is a study to decellularize organs and reconstruct the structural information of the extracellular matrix in order to create decellularized medical materials that can be used for the anti-allergic agent search system in tissue engineering. The implication of these antiallergic agents varied greatly depending on the individual, and there is a demand for regenerative medicine. There is a separate "model organ that reflects biological characteristics" that replaces drug testing, which places a heavy burden on patients. As a regenerative medical material, a cell-removed extracellular matrix derived from a living body is suitable for a scaffold for cell proliferation. We have developed a method for producing bioscaffold organs decellularized from organs of different mammals such as, pigs, etc. by using ultrasonic waves together with supercritical carbon dioxide, which is harmless to the living body and whose solvent properties are easy to control.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究は、脱化石資源が求められる国際社会で、高齢化社会における持続可能な高度技術を利用した高付加価値製品生産の基盤技術の創製である。生体に害がなく溶媒特性の制御が容易である超臨界二酸化炭素と超音波を併用し、生体複合材料調整に係わるナノ構造制御技術として、超臨界ナノ制御、ナノバブル、ナノ界面制御技術を開発した。従来の技術では、実用製品の機能・価格競争力の証明が課題となっている。本研究では、その課題解決策として、二酸化炭素と水が作り出すナノサイズの気液界面により、ナノメートルオーダーの微細構造制御を容易にし、有機溶媒を使用せず、安価で高機能性材料の創製を可能にする装置技術を提供した。
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Report
(4 results)
Research Products
(101 results)
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[Journal Article] Rapid Production of Liposomes Using High Pressure Carbon Dioxide and Direct Ultrasonication2020
Author(s)
Shinichi Tokunaga, Hiroyuki Tashiro, Kento Ono, Tanjina Sharmin, Takafumi Kato, Keiichi Irie, Kenichi Mishima, Tomomitsu Satho, Taku M. Aida, Kenji Mishima,
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Journal Title
J. Supercritical Fluids
Volume: 160
Pages: 104782-104782
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Basic Spectroscopic Study for Effect of Alubumin for Drug Delivery System,2017
Author(s)
M. Haraguchi, S. Tokunaga, S. Ito, K. Mishima, T. Sharmin, M. Nakamura, T. Kato, M. Misumi, T. Suetsugu, H. Orii, T. Harada
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Journal Title
Proceedings of the 15th Korea / Japan International Symposium on Resources Recycling and Materials Science, 2017
Volume: 1
Pages: 281-281
Related Report
Peer Reviewed
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[Journal Article] Effective Utilization of CO2 in Manufacturing pH-Responsive Microparticle,2017
Author(s)
S. Tokunaga, M. Haraguchi, S. Ito, K. Mishima, T. Sharmin, M. Nakamura, T. Kato, M. Misumi, T. Suetsugu, H. Orii, T. Harada,
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Journal Title
Proceedings of the 15th Korea / Japan International Symposium on Resources Recycling and Materials Science, 2017
Volume: 1
Pages: 283-283
Related Report
Peer Reviewed
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[Journal Article] Novel Production Method of pH-Responsive Microcapsules for DDS2017
Author(s)
S. Tokunaga, M. Haraguchi, S. Ito, K. Mishima, T. Sharmin, M. Nakamura, T. Kato, M. Misumi, T. Suetsugu, H. Orii, T. Harada,
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Journal Title
Proceedings of the 7th Asian Particle Technology Symposium (Chang Gung University,Taiwan)
Volume: 1
Pages: 115-120
Related Report
Peer Reviewed
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[Journal Article] Production of pH-responsive composite microcapsules and sustained release rate2017
Author(s)
S.Tokunaga, M. Haraguchi, S. Ito, K. Mishima, T. Sharmin, Mi. Nakamura, T. Kato, M. Misumi, T. Suetsugu, H. Orii, T. Harada
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Journal Title
Proceedings of the 5th International Symposium & Exhibition on Aqua Science and Water Resources (ISASWR’17)
Volume: 1
Pages: 173-178
Related Report
Peer Reviewed
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[Journal Article] Ethanol modified liquid carbon dioxide extraction of nobiletin and tangeretin with antioxidant activity from peels of Citrus poonensis2017
Author(s)
R. Mitani, S. Tokunaga, M. Haraguchi, K. Mishima, T. Sharmin, M. Nakamura, Takafumi Kato, M. Misumi, T. Suetsugu, H. Orii, K. Irie, T. Satho, T. Harada
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Journal Title
Proceedings of the 5th International Symposium & Exhibition on Aqua Science and Water Resources (ISASWR’17)
Volume: 1
Pages: 258-261
Related Report
Peer Reviewed
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[Journal Article] Formation of Functional Microcapsules Using Pressure-Induced Phase Separation of CO2 Solution,2017
Author(s)
K. Mishima, S. Tokunaga, M. Haraguchi, T. Sharmin, M. Nakamura, T. Kato, M. Misumi, T. Suetsugu, H. Orii, T. Harada
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Journal Title
Proceedings of the 17th Congress, Asian Pacific Confederation of Chemical Engineering(APPCE)
Volume: 1
Pages: 78-78
Related Report
Peer Reviewed
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