| Project/Area Number |
17K06930
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biofunction/Bioprocess
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| Research Institution | University of Miyazaki |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
山崎 正夫 宮崎大学, 農学部, 教授 (80381060)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 難水溶性 / 消化ペプチド / 水溶化 / 分散 / コロイド / 難水溶性薬物 / 経口吸収性 |
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| Outline of Final Research Achievements |
The structural requirements for digestive peptides that form complexes with poorly water-soluble ingredients to improve the water dispersibility and oral absorption. As a result, digested peptides with high molecular weight and high hydrophobicity were found to be effective to improve the dispersibility of poorly water-soluble ingredients. On the other hand, the water solubility and water dispersibility of the complexes between various poorly water-soluble substances with different molecular weights and hydrophobicity and digested peptides were investigated. The molecular weight and hydrophobicity of the poorly water-soluble substance are the dominant factors to determine the dispersion state of the complex. Furthermore, enhancement of cell-permeability of poorly water-soluble ingredients by the complexation with digested peptides was confirmed by cell permeation tests using cell monolayer membrane using Caco-2 cell membrane.
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| Academic Significance and Societal Importance of the Research Achievements |
新規に見出される薬物候補化合物が難水溶性だと血中投与および経口投与の障害となり実用化が断念されることも多い。他方、健康機能性のある生理活性物質の多くは難水溶性で、食品等から単離すると経口吸収性が著しく低下する。本研究はこうした難水溶性物質と複合化することで、水分散性および経口吸収性の改善に寄与する消化ペプチドの構造的要件を明らかにした。このような可溶化技術により機能性成分の吸収性と薬理効果の改善、処方量減による副作用低減、薬価の低下などに貢献しうる。
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