| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
The underlying principles that allow axons to compete with each other to mature their connections to target cells during developmental neural reorganization are still poorly understood. To experimentally test the hypothesis that the number of targets dominated by each axon depend on the number of competitors, we used ciliary ganglion synapses as a model system in which presynaptic connections converge from one-to-many to one-to-one during development. We quantitatively assessed axon projection patterns when the number of presynaptic neurons is genetically thinned out. As a result, halving the number of presynaptic neurons did not change the number of synapses formed by axons, and the number of postsynaptic neurons also decreased. This result suggests that the number of targets dominated by each axon may be destined by endogenous molecular/cellular mechanisms, rather than by the number of competitors.
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