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How does a single neural network generate multiple patterns of motions?

Research Project

Project/Area Number 17K07042
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Neurophysiology / General neuroscience
Research InstitutionThe University of Tokyo

Principal Investigator

Kohsaka Hiroshi  東京大学, 大学院新領域創成科学研究科, 講師 (20431900)

Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords運動回路 / 神経回路 / コネクトミクス / 運動制御 / ショウジョウバエ / 遺伝学 / オプトジェネティクス / 介在神経細胞 / 軸性伝播
Outline of Final Research Achievements

Animals are able to move in multiple locomotion patterns. In this study, we examined mechanisms how a single neural circuit generates multiple motion patterns by using the motor systems of Drosophila larvae as a model. We identified two novel interneurons: Ifb-Fwd (which is activated in forward but not backward crawling) and Ifb-Bwd (which is activated in backward but not forward crawling). These findings suggest that distinct circuit modules for distinct motor patterns are implemented in the central nervous system.

Academic Significance and Societal Importance of the Research Achievements

動物は、多様な運動パターンで動くことができます。例えば、ヒトは前歩きと後ろ歩きができます。しかし、ヒトには一つの中枢神経系しかありません。一つの神経回路がどのようにして異なる運動パターンを生み出すのか、その仕組みは不明でした。本研究では、ショウジョウバエを実験モデルとして用いて、運動に関わる神経回路を詳しく調べました。その結果、異なる運動を生み出すために、それぞれの運動専用の神経細胞があることを発見しました。このことから、神経回路の中には、異なる運動パターンを生み出すためにそれぞれの専用回路が組み込まれていることが明らかになりました。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (32 results)

All 2019 2018 2017 Other

All Int'l Joint Research (5 results) Journal Article (6 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 5 results,  Open Access: 5 results) Presentation (19 results) (of which Int'l Joint Research: 7 results,  Invited: 2 results) Remarks (2 results)

  • [Int'l Joint Research] HHMI Janelia Research Campus/Columbia University/University of Washington(米国)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] University of St. Andrews/University of Cambridge(英国)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] Janelia research campus/University of Washington(米国)

    • Related Report
      2018 Research-status Report
  • [Int'l Joint Research] University of St. Andrews/University of Cambridge(英国)

    • Related Report
      2018 Research-status Report
  • [Int'l Joint Research] HHMI Janelia research campus(米国)

    • Related Report
      2017 Research-status Report
  • [Journal Article] Regulation of forward and backward locomotion through intersegmental feedback circuits in Drosophila larvae2019

    • Author(s)
      Kohsaka Hiroshi、Zwart Maarten F.、Fushiki Akira、Fetter Richard D.、Truman James W.、Cardona Albert、Nose Akinao
    • Journal Title

      Nature Communications

      Volume: 10 Issue: 1 Pages: 1-11

    • DOI

      10.1038/s41467-019-10695-y

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] System level analysis of motor-related neural activities in larval Drosophila2019

    • Author(s)
      Yoon Youngteak、Park Jeonghyuk、Taniguchi Atsushi、Kohsaka Hiroshi、Nakae Ken、Nonaka Shigenori、Ishii Shin、Nose Akinao
    • Journal Title

      Journal of Neurogenetics

      Volume: 33 Issue: 3 Pages: 179-189

    • DOI

      10.1080/01677063.2019.1605365

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Data-driven analysis of motor activity implicates 5-HT2A neurons in backward locomotion of larval Drosophila2018

    • Author(s)
      Park Jeonghyuk、Kondo Shu、Tanimoto Hiromu、Kohsaka Hiroshi、Nose Akinao
    • Journal Title

      Scientific Reports

      Volume: 8 Issue: 1 Pages: 1-15

    • DOI

      10.1038/s41598-018-28680-8

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] ショウジョウバエ幼虫を動かす神経回路機構2018

    • Author(s)
      高坂洋史
    • Journal Title

      比較生理生化学

      Volume: 35(2) Pages: 93-99

    • NAID

      130007435530

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Data-driven analysis of motor activity implicated 5-ht2a neurons in backward locomotion of larval Drosophila.2018

    • Author(s)
      Park, J., Kondo, S., Tanimoto, H., Kohsaka, H., Nose, A.
    • Journal Title

      bioRxiv

      Volume: 257568

    • Related Report
      2017 Research-status Report
    • Open Access
  • [Journal Article] Divergent Connectivity of Homologous Command-like Neurons Mediates Segment-Specific Touch Responses in Drosophila2017

    • Author(s)
      Takagi Suguru、Cocanougher Benjamin Thomas、Niki Sawako、Miyamoto Dohjin、Kohsaka Hiroshi、Kazama Hokto、Fetter Richard Doty、Truman James William、Zlatic Marta、Cardona Albert、Nose Akinao
    • Journal Title

      Neuron

      Volume: 96 Issue: 6 Pages: 1373-1387.e6

    • DOI

      10.1016/j.neuron.2017.10.030

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] A neuromechanical model for forward locomotion of Drosophila larvae.2019

    • Author(s)
      Sun X., Nose A. and Kohsaka H.
    • Organizer
      東大-浙江大合同シンポジウム
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Regulation of forward and backward locomotion through intersegmental feedback circuits in Drosophila larvae.2019

    • Author(s)
      Kohsaka H., Zwart M.F., Fushiki A., Fetter R.D., Truman J.W., Cardona A. and Nose A.
    • Organizer
      The 26th European Drosophila research conference EDRC 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Dynamic modules underlying multiple motor patterns in Drosophila CNS revealed by populational synapse imaging.2019

    • Author(s)
      Fukumasu K., Nose A. and Kohsaka H.
    • Organizer
      第42 回日本神経科学大会
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Neural activities related to axial locomotion in the terminal segments of Drosophila larval CNS2019

    • Author(s)
      Y. Liu, A. Nose and H. Kohsaka
    • Organizer
      2019 ASIA-PACIFIC DROSOPHILA NEUROBIOLOGY CONFERENCE
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Analysis of populational synapse activity in Drosophila nervous system revealed dynamic modules underlying multiple behaviors2019

    • Author(s)
      K. Fukumasu, A. Nose and H. Kohsaka
    • Organizer
      SNSS2019
    • Related Report
      2018 Research-status Report
  • [Presentation] A modular structure in premotor circuits for bidirectional axial locomotion2018

    • Author(s)
      H. Kohsaka, M.F. Zwart, A. Fushiki, R.D. Fetter, J.W. Truman, A. Cardona, and A. Nose
    • Organizer
      Behavioral neurogenetics of Drosophila larva
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Motor circuits in Drosophila larvae2018

    • Author(s)
      H. Kohsaka
    • Organizer
      Developmental Neurobiology Course 2018
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] Analysis of spontaneous neural activity patterns in the fly embryos2018

    • Author(s)
      H. Kohsaka, R.K. Chhetri, W.C. Lemon, P.J. Keller and A. Nose
    • Organizer
      The Joint Research Area Meeting Scientific Research on Innovative Areas. “Artificial Intelligence and Brain Science ”and“ Adaptive Circuit Shift ”
    • Related Report
      2018 Research-status Report
  • [Presentation] Analysis of neural network by machine learning aided Gal4 line screening and neural activity visualization in the terminal segments of Drosophila larval CNS2018

    • Author(s)
      Y. Liu, A. Nose and H. Kohsaka
    • Organizer
      第41 回日本分子生物学会年会
    • Related Report
      2018 Research-status Report
  • [Presentation] 運動神経回路発達における神経活動遷移のCa2+ イメージングによる解析2018

    • Author(s)
      戸松一貴、能瀬聡直、高坂洋史
    • Organizer
      第41 回日本分子生物学会年会
    • Related Report
      2018 Research-status Report
  • [Presentation] Divergent connectivity of homologous command-like neurons mediates segment-specific touch responses in Drosophila2017

    • Author(s)
      Suguru Takagi, Benjamin T. Cocanougher, Sawako Niki, Dohjin Miyamoto, Hiroshi Kohsaka, Hokto Kazama, Richard D. Fetter, James W. Truman, Marta Zlatic, Albert Cardona, Akinao Nose.
    • Organizer
      Cold Spring Harbor Laboratry, USA
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Ca imaging and electrophysiological recording from Drosophila larvae2017

    • Author(s)
      Kohsaka, H.
    • Organizer
      Developmental Neurobiology Course 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Divergent connectivity of command-like neurons mediates segment-specific touch responses in Drosophila larvae2017

    • Author(s)
      高木優, Benjamin Cocanougher, 二木佐和子, 宮本道人, 高坂洋史, 風間北斗, Richard Fetter, James Truman, Marta Zlatic, Albert Cardona, 能瀬聡直
    • Organizer
      第17回東京大学生命科学シンポジウム
    • Related Report
      2017 Research-status Report
  • [Presentation] Identication and imaging of interneurons related to the motor control of Drosophila larvae2017

    • Author(s)
      Kohsaka, H., Xiangsunze, Z., Kawasaki, T. and Nose A.
    • Organizer
      新学術領域研究「適応回路シフト」第5回領域班会議
    • Related Report
      2017 Research-status Report
  • [Presentation] Bidirectional feedback circuits regulate propagation of motor activity in opposite directions.2017

    • Author(s)
      Kohsaka, H., Zwart, M.F., Fushiki, A., Fetter, R. D., Truman, J. W., Cardona, A. and Nose A.
    • Organizer
      第40回日本神経科学大会
    • Related Report
      2017 Research-status Report
  • [Presentation] Identication of interneurons that regulate backward locomotion during light-avoidance behavior in Drosophila larvae.2017

    • Author(s)
      Shoya Ohura, Hiroshi Kohsaka, Akinao Nose
    • Organizer
      第40回日本神経科学大会
    • Related Report
      2017 Research-status Report
  • [Presentation] A segment-specific sensorimotor pathway mediates touch-triggered backward escape response in Drosophila larvae2017

    • Author(s)
      Suguru Takagi, Benjamin T. Cocanougher, Sawako Niki, Dohjin Miyamoto, Hiroshi Kohsaka, Hokto Kazama, Richard D. Fetter, James W. Truman, Marta Zlatic, Albert Cardona, Akinao Nose
    • Organizer
      第40回日本神経科学大会
    • Related Report
      2017 Research-status Report
  • [Presentation] ショ ウジョウバエ幼虫の光逃避行動において後退運動を制御する介在神経細胞の同定2017

    • Author(s)
      Shoya Ohura, Hiroshi Kohsaka, Akinao Nose
    • Organizer
      第40回日本分子生物学会年会
    • Related Report
      2017 Research-status Report
  • [Presentation] ショウジョウバエ近縁種における幼虫行動特性の比較解析2017

    • Author(s)
      松尾悠司、能瀬聡直、高坂洋史
    • Organizer
      第40回日本分子生物学会
    • Related Report
      2017 Research-status Report
  • [Remarks] 前に行ったり、後ろに行ったり:1つの神経回路が異なる動きを効率よく生み出すしくみ

    • URL

      http://www.k.u-tokyo.ac.jp/info/entry/22_entry747/

    • Related Report
      2019 Annual Research Report
  • [Remarks] 「臨機応変」を配線する:動物の行動選択を担う神経回路メカニズムの解明

    • URL

      http://www.k.u-tokyo.ac.jp/info/entry/22_entry618/

    • Related Report
      2017 Research-status Report

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Published: 2017-04-28   Modified: 2022-02-21  

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