How does a single neural network generate multiple patterns of motions?
| Project/Area Number |
17K07042
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Neurophysiology / General neuroscience
|
|---|
| Research Institution | The University of Tokyo |
|---|
Principal Investigator |
Kohsaka Hiroshi 東京大学, 大学院新領域創成科学研究科, 講師 (20431900)
|
|---|
| Project Period (FY) |
2017-04-01 – 2020-03-31
|
| Project Status |
Completed (Fiscal Year 2019)
|
| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
|---|
| Keywords | 運動回路 / 神経回路 / コネクトミクス / 運動制御 / ショウジョウバエ / 遺伝学 / オプトジェネティクス / 介在神経細胞 / 軸性伝播 |
|---|
| Outline of Final Research Achievements |
Animals are able to move in multiple locomotion patterns. In this study, we examined mechanisms how a single neural circuit generates multiple motion patterns by using the motor systems of Drosophila larvae as a model. We identified two novel interneurons: Ifb-Fwd (which is activated in forward but not backward crawling) and Ifb-Bwd (which is activated in backward but not forward crawling). These findings suggest that distinct circuit modules for distinct motor patterns are implemented in the central nervous system.
|
| Academic Significance and Societal Importance of the Research Achievements |
動物は、多様な運動パターンで動くことができます。例えば、ヒトは前歩きと後ろ歩きができます。しかし、ヒトには一つの中枢神経系しかありません。一つの神経回路がどのようにして異なる運動パターンを生み出すのか、その仕組みは不明でした。本研究では、ショウジョウバエを実験モデルとして用いて、運動に関わる神経回路を詳しく調べました。その結果、異なる運動を生み出すために、それぞれの運動専用の神経細胞があることを発見しました。このことから、神経回路の中には、異なる運動パターンを生み出すためにそれぞれの専用回路が組み込まれていることが明らかになりました。
|
Report
(4 results)
Research Products
(32 results)
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] Divergent connectivity of homologous command-like neurons mediates segment-specific touch responses in Drosophila2017
Author(s)
Suguru Takagi, Benjamin T. Cocanougher, Sawako Niki, Dohjin Miyamoto, Hiroshi Kohsaka, Hokto Kazama, Richard D. Fetter, James W. Truman, Marta Zlatic, Albert Cardona, Akinao Nose.
Organizer
Cold Spring Harbor Laboratry, USA
Related Report
Int'l Joint Research
-
-
[Presentation] Divergent connectivity of command-like neurons mediates segment-specific touch responses in Drosophila larvae2017
Author(s)
高木優, Benjamin Cocanougher, 二木佐和子, 宮本道人, 高坂洋史, 風間北斗, Richard Fetter, James Truman, Marta Zlatic, Albert Cardona, 能瀬聡直
Organizer
第17回東京大学生命科学シンポジウム
Related Report
-
-
[Presentation] Bidirectional feedback circuits regulate propagation of motor activity in opposite directions.2017
Author(s)
Kohsaka, H., Zwart, M.F., Fushiki, A., Fetter, R. D., Truman, J. W., Cardona, A. and Nose A.
Organizer
第40回日本神経科学大会
Related Report
-
-
[Presentation] A segment-specific sensorimotor pathway mediates touch-triggered backward escape response in Drosophila larvae2017
Author(s)
Suguru Takagi, Benjamin T. Cocanougher, Sawako Niki, Dohjin Miyamoto, Hiroshi Kohsaka, Hokto Kazama, Richard D. Fetter, James W. Truman, Marta Zlatic, Albert Cardona, Akinao Nose
Organizer
第40回日本神経科学大会
Related Report
-
-
-
-
