| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
|---|
| Outline of Final Research Achievements |
The supramammillary nucleus (SuM) of the hypothalamus projects to the dentate gyrus and the CA2 region of the hippocampus. Although the SuM to hippocampus circuits have been implicated in spatial and emotional memory formation, little is known about precise neural connections between the SuM and hippocampus. By using optogenetics and electrophysiology, we found that the SuM neurons project to both granule cells and GABAergic interneurons and co-release glutamate and GABA. We also found that SuM inputs potentiate granule cell firing when temporally associated with perforant path inputs. These results indicate that the SuM modulates dentate gyrus activity by modulating granule cell outputs.
|
