| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
During the brain development, newborn neurons derived from neural progenitor cells undergo neuronal migration. The process (neurogenesis and neuronal migration) is essential for neurodevelopment. However, the cell-extrinsic signals that govern neurogenesis and neuronal migration are poorly understood. In the present study, we find that lysophosphatidic acid acts as an important extrinsic signal that direct neuronal migration. In detail, lysophosphatidic acid contributes to the morphological transformation of newborn neurons to undergo neuronal migration through LPA receptor 4 expressed in migratory neurons. The present study thus uncovered the molecular machinery and role of the interface between migratory neurons and their extracellular environment.
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