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Simulation study on functional roles of morphological strucutre of neurons in cerebellar learning

Research Project

Project/Area Number 17K07049
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Neurophysiology / General neuroscience
Research InstitutionThe University of Electro-Communications

Principal Investigator

Yamazaki Tadashi  電気通信大学, 大学院情報理工学研究科, 准教授 (40392162)

Co-Investigator(Kenkyū-buntansha) 五十嵐 潤  国立研究開発法人理化学研究所, 情報システム本部, 上級研究員 (60452827)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2019: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2018: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2017: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Keywords小脳 / シミュレーション / スパイキングニューロン / マルチコンパートメント / 数値シミュレーション / マルチコンパートメントモデル / 並列計算 / GPU / 学習 / 細胞形状 / 計算論的神経科学 / 細胞形態 / 高性能神経計算
Outline of Final Research Achievements

Neurons have characterstic morphotogical structures, yet how the structures affect information processing in the brain remains unknown. In this study, we built a spiking network model of the cerebellar cortex composed of Purkinje cells, granule cells, and Golgi cells, that have detailed and realistic morphological shapes. We employed a graphics processing unit (GPU) for parallel computing and achieved 24 times faster numerical simulation than a standard CPU. The network exhibited synchronous oscillatory firing of granule cells and Golgi cells at around 14 Hz, whereas Purkinje cells also emitted spikes with the correlated firing rate. We found that when the dendrites of the Purkinje cells were shrinked, which was observed in animals with neuronal / genetic disorders, the synchronized firing among the Purkinje cells was disrupted. These results suggest that morphological structure of neurons play important roles in normal brain functions.

Academic Significance and Societal Importance of the Research Achievements

ニューロンの空間形状が脳の情報処理に及ぼす影響を解明するためには、実際に形状を変化させることが必要だが、それを実験的に行うことは極めて難しい。一方、計算機シミュレーションではそれは容易である。ニューロンの空間形状の変化は神経疾患・遺伝子疾患でしばしば見られる現象であり、そのような深刻な病気に何らかの影響を与えているはずである。本研究はそのような病気の原因解明に資するツールとして神経回路シミュレーションを提案するものである。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (9 results)

All 2019 2017 Other

All Int'l Joint Research (1 results) Presentation (8 results) (of which Int'l Joint Research: 5 results,  Invited: 2 results)

  • [Int'l Joint Research] University of Pavia(イタリア)

    • Related Report
      2019 Annual Research Report
  • [Presentation] Dendritic discrimination of temporal input sequences in cerebellar Purkinje cells2019

    • Author(s)
      Yuki Yamamoto, Tadashi Yamazaki
    • Organizer
      Computational Neuroscience (CNS*2019)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Large-scale simulation of the little brain2019

    • Author(s)
      Tadashi Yamazaki
    • Organizer
      RIKEN Workshop on Neuromorphic Computing
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Parallel numerical simulation of a multicompartment network model of the cerebellum on GPU2019

    • Author(s)
      Taira Kobayashi, Tadashi Yamazaki
    • Organizer
      第29回日本神経回路学会全国大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Dendritic discrimination of temporal input sequences in cerebellar Purkinje cells2019

    • Author(s)
      Yuki Yamamoto, Tadashi Yamazaki
    • Organizer
      Computational Neuroscience 2019 (CNS*2019)
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] 小脳顆粒層のマルチコンパートメントモデルシミュレーション2017

    • Author(s)
      露木 吏, 山本 祐輝, 山﨑 匡
    • Organizer
      第27 回日本神経回路学会全国大会
    • Related Report
      2017 Research-status Report
  • [Presentation] Implementing synaptic plasticity on a cat-scale artificial cerebellum2017

    • Author(s)
      Tadashi Yamazaki, Wataru Furusho
    • Organizer
      第40回日本神経科学大会,
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Implementation of Learning Mechanisms on a Cat-scale Cerebellar Model and its Simulation2017

    • Author(s)
      Wataru Furusho, Tadashi Yamazaki
    • Organizer
      26th International Conference on Artificial Neural Networks (ICANN) 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] ヒト規模の脳神経回路シミュレーションを目指して: 小脳の場合2017

    • Author(s)
      山﨑 匡
    • Organizer
      科学技術計算分科会2017年度会合「拡がるHPC ~新たな鼓動~」
    • Related Report
      2017 Research-status Report
    • Invited

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Published: 2017-04-28   Modified: 2021-02-19  

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