| Project/Area Number |
17K07052
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurophysiology / General neuroscience
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| Research Institution | University of Toyama |
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Principal Investigator |
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2019: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2018: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2017: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
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| Keywords | 聴覚系 / 随伴発射 / ラット / 超音波発声 / 統合失調症 / ドーパミン |
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| Outline of Final Research Achievements |
Auditory hallucinations in schizophrenia are suggested to be produced by misidentification of inner speech as external voices. However, detailed neural mechanisms underlying discrimination of self/other voices and its impairment in schizophrenia are unknown. In this study, we first investigated neural response to own and other’s vocalizations in the amygdala and the auditory cortex in rats. Then, we tested effects of methamphetamine administration, which causes auditory hallucinations in humans, on neural responses to vocalizations. The results indicated that methamphetamine specifically enhanced responses to own vocalizations, suggesting that this enhancement might be involved in impaired self/other distinction in the auditory cortex and auditory hallucination. The present results and the experimental paradigms should be useful to future studies to clarify neural mechanisms of auditory hallucinations using animals and contribute to development of treatments for schizophrenia.
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| Academic Significance and Societal Importance of the Research Achievements |
幻聴は内的な体験であり、言語を持たない動物ではその神経メカニズムを研究することがこれまで困難であった。本研究で開発した実験手法や得られた実験結果は、動物を用いた幻聴の詳しい神経メカニズムの研究の基礎となり、今後統合失調症の治療法の開発などに大いに貢献することが期待される。
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