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Origin and diversification of the vertebrate telencephalon

Research Project

Project/Area Number 17K07059
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Neurophysiology / General neuroscience
Research InstitutionEhime University

Principal Investigator

Murakami Yasunori  愛媛大学, 理工学研究科(理学系), 教授 (50342861)

Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords脳 / 進化 / 遺伝子 / 脊椎動物 / 発生 / 発生・分化 / 終脳
Outline of Final Research Achievements

Vertebrate brains have evolved a variety of morphology. Recent studies have revealed that some signaling molecules and transcription factors play a fundamental role in the regionalization of the telencephalon. Our recent study using cyclostomes (lampreys and hagfishes) suggested that combinatory expression of regulatory genes may have been established before the split of cyclostomes and gnathostomes (jawed vertebrates). On the other hand, the size and functions of integrative centers are thought to have been modified in vertebrate lineages. To identify the molecular mechanism underlying brain diversification, we studied the development of catfish facial lobe, a center for the gustatory system. We found that FGF and WNT signal-inhibitor treated embryos resulted in the reduction of the facial lobe. Therefore, the modification of expression domains of signaling molecules may play a key role in the lineage-specific morphological change of the brain regions.

Academic Significance and Societal Importance of the Research Achievements

我々の意識の源であり、自分自身そのものともいえる脳がどのようにして進化してきたのかは、一般の人々にとってもたいへん興味深いテーマである。本研究では脳の起源と多様化の仕組みを明らかにすることで、一般の人々の興味にも応えられる研究成果を得た。この結果について、その他の動物の脳の知見もまとめつつ、高校生以上を対象にした書籍「遺伝子から解き明かす脳の不思議な世界(一色出版)」として出版することで、国民に脳の進化過程についてわかりやすく紹介することができた。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (25 results)

All 2019 2018 2017

All Journal Article (6 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 6 results,  Open Access: 2 results,  Acknowledgement Compliant: 1 results) Presentation (16 results) (of which Int'l Joint Research: 3 results,  Invited: 7 results) Book (3 results)

  • [Journal Article] FGF- and SHH-based molecular signals regulate barbel and craniofacial development in catfish.2019

    • Author(s)
      Itoyama T, Fukui M, Kawaguchi M, Kaneko S, Sugahara F, Murakami Y
    • Journal Title

      Zoological letters

      Volume: 5 Issue: 1 Pages: 19-19

    • DOI

      10.1186/s40851-019-0135-1

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Atlas of the telencephalon based on cytoarchitecture, neurochemical markers, and gene expressions in Rhinogobius flumineus [Mizuno, 1960].2019

    • Author(s)
      Kawaguchi M, Hagio H, Yamamoto N, Matsumoto K, Nakayama K, Akazome Y, Izumi H, Tsuneoka Y, Suto F, Murakami Y, Ichijo H.
    • Journal Title

      J Comp Neurol.

      Volume: 527 Issue: 4 Pages: 874-900

    • DOI

      10.1002/cne.24547

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Egg structure and outline of embryonic development of the basal mantodean, Metallyticus splendidus Westwood, 1835 (Insecta, Mantodea, Metallyticidae).2018

    • Author(s)
      Fukui M, Fujita M, Tomizuka S, Mashimo Y, Shimizu S, Lee CY, Murakami Y, Machida R.
    • Journal Title

      Arthropod Struct Dev.

      Volume: 47(1) Issue: 1 Pages: 64-73

    • DOI

      10.1016/j.asd.2017.11.001

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Expression patterns of Sema3A in developing amniote limbs: With reference to the diversification of peripheral nerve innervation.2017

    • Author(s)
      Noguchi K, Ishikawa R, Kawaguchi M, Miyoshi K, Kawasaki T, Hirata T, Fukui M, Kuratani S, Tanaka M, Murakami Y.
    • Journal Title

      Dev Growth Differ.

      Volume: 59(4) Issue: 4 Pages: 270-285

    • DOI

      10.1111/dgd.12364

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Reconstructing the ancestral vertebrate brain.2017

    • Author(s)
      Sugahara F, Murakami Y, Pascual-Anaya J, Kuratani S.
    • Journal Title

      Dev Growth Differ.

      Volume: 59(4) Issue: 4 Pages: 163-174

    • DOI

      10.1111/dgd.12347

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Evolutionary mechanisms that generate morphology and neural-circuit diversity of the cerebellum.2017

    • Author(s)
      Hibi M, Matsuda K, Takeuchi M, Shimizu T, Murakami Y.
    • Journal Title

      Development, Growth & Differentiation

      Volume: 印刷中 Issue: 4 Pages: 228-243

    • DOI

      10.1111/dgd.12349

    • NAID

      120006406681

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] The role of signaling molecules in the evolution of the vertebrate brain2019

    • Author(s)
      Murakami Y
    • Organizer
      52nd Annual Meeting of the Japanese Society of Developmental Biologists
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 脊椎動物の脳における新規構造の獲得2019

    • Author(s)
      村上安則
    • Organizer
      日本動物学会 第90回大阪大会シンポジウム 動物形態のパターン形成:アロモルフォーゼ再考
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 脊椎動物の高次中枢の起源2019

    • Author(s)
      村上安則
    • Organizer
      日本進化学会シンポジウム こころの進化の神経基盤
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 脊椎動物の脳の起源と新規領域の獲得2019

    • Author(s)
      村上安則
    • Organizer
      121回日仏生物学会例会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 鰓弓神経の起源と進化2019

    • Author(s)
      村上安則
    • Organizer
      第124回日本解剖学会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] ナマズ目の顔面葉形成に関わる分子機構2018

    • Author(s)
      金子紗希, 舞田穂波, 川中寅生, 糸山達哉, 村上安則.
    • Organizer
      第8回Tokyo Vertebrate Morphology Meeting
    • Related Report
      2018 Research-status Report
  • [Presentation] 円口類ヤツメウナギの脳に関する進化発生学的研究2018

    • Author(s)
      村上安則
    • Organizer
      動物進化研究集会
    • Related Report
      2018 Research-status Report
  • [Presentation] ナマズ(Silurus Asotus)の顔面葉の発生起源とその形成機構2018

    • Author(s)
      金子紗希, 糸山達哉, 川中寅生, 村上安則.
    • Organizer
      日本動物学会 第89回 札幌大会
    • Related Report
      2018 Research-status Report
  • [Presentation] Origin and evolution of the cerebellum.2018

    • Author(s)
      Yasunori Murakami
    • Organizer
      The 75th FUJIHARA seminar
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 円口類の神経発生から解き明かす脳の起源と多様化2017

    • Author(s)
      村上安則
    • Organizer
      日本動物学会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] 脊椎動物における終脳発生機構の進化的変遷2017

    • Author(s)
      河原萌恵, 奥村光祐, 楠原佑基, 菅原文昭, 工樂樹洋, 倉谷滋, 村上安則
    • Organizer
      日本動物学会
    • Related Report
      2017 Research-status Report
  • [Presentation] 爬虫類の終脳発生と軸索投射に関わる分子機構:羊膜類の終脳形成機構の進化2017

    • Author(s)
      有田光宏, 原田千春, 平尾綾子, 土佐靖彦, 村上安則
    • Organizer
      日本動物学会
    • Related Report
      2017 Research-status Report
  • [Presentation] ナマズ目の顔面葉形成におけるシグナル分子の役割:菱脳の多様化に関わる分子機構2017

    • Author(s)
      金子紗希, 川中寅生, 舞田穂波, 糸山達哉, 村上安則
    • Organizer
      日本動物学会
    • Related Report
      2017 Research-status Report
  • [Presentation] ナマズ(Silurus asotus)の脳形成に関わるシグナル分子の役割2017

    • Author(s)
      金子紗希, 川中寅生, 舞田穂波, 糸山達哉, 村上安則
    • Organizer
      第38回菅平動物学セミナー
    • Related Report
      2017 Research-status Report
  • [Presentation] ソメワケササクレヤモリ(Paroedura picta)の終脳形成に関わる分子基盤;羊膜類の終脳発生機構の起源と進化2017

    • Author(s)
      有田光宏, 今井ひとみ, 平尾綾子, 土佐靖彦, 村上安則
    • Organizer
      第38回菅平動物学セミナー
    • Related Report
      2017 Research-status Report
  • [Presentation] トラザメ(Scyliorhinus torazame) とナマズ(Silurus asotus)の終脳形成機構とその進化的変遷2017

    • Author(s)
      河原萌恵, 菅原文昭, 菅原由貴, 倉谷滋,村上安則
    • Organizer
      第38回菅平動物学セミナー
    • Related Report
      2017 Research-status Report
  • [Book] 脊椎動物の小脳の起源と構造 Clinical Neuroscience 小脳学習説 Marr-Albus-Ito理論の50年2019

    • Author(s)
      村上安則
    • Total Pages
      4
    • Publisher
      中外医学社
    • Related Report
      2019 Annual Research Report
  • [Book] ストラスブールでの生活 日仏生物学会誌第58巻2019

    • Author(s)
      村上安則
    • Total Pages
      2
    • Publisher
      日仏生物学会
    • Related Report
      2019 Annual Research Report
  • [Book] 遺伝子から解き明かす脳の不思議な世界2019

    • Author(s)
      滋野修一(編著)、野村真(編著)、村上安則(編著)
    • Total Pages
      520
    • Publisher
      一色出版
    • ISBN
      4909383050
    • Related Report
      2018 Research-status Report

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Published: 2017-04-28   Modified: 2021-02-19  

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