| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
The cerebral cortex is composed of hundreds of different subtypes of neurons, which are sequentially generated from common neural progenitor cells. This sequential specification has been interpreted as a result from the sequential changes of differentiation potential of progenitor cells. However, the molecular mechanisms regulating this sequential changes have been poorly understood. We focused on transcription factors Neurog1/2, which are expressed by neural progenitor cells throughout cortical neurogenesis but only participate in subtype specification of deep layer neurons. We found the importance of the temporal regulation of transcriptional activity of Neurog1/2 and the epigenetic regulation by polycomb repressive complexes.
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