| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
Collagen XXV has been identified as a component of senile plaques in Alzheimer’s disease. In this study, we demonstrated that collagen XXV affects the compaction of amyloid plaques and consequently the brain dynamics of Aβ.
We also revealed the molecular mechanism of binding of collagen XXV to its interactor RPTPσ/δ, which are implicated in synaptic organization and axon guidance. To elucidate further the pathological mechanism of a congenital cranial dysinnervation disorder (CCDD) caused by mutations in the COL25A1 gene, the effect of mutant collagen XXV on motor innervation was examined. Analysis of muscle-specific Col25a1 KO mice showed that muscle-derived collagen XXV is important for the development of cranial motor neurons. We also showed that CCDD mutations in collagen XXV impair the binding to RPTPσ/δ, resulting in reduced interaction with motor axons.
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