| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
Immunohisatochemistry for prion protein (PrP) on some prion diseases (sporadic Creutzfeldt-Jakob diseases and Gerstmann-Strussler-Scheinker diseases) revealed positive findings of PrP in in many adenohypophyseal cells. Proteomics analysis also revealed PrP in pituitary samples. Western blots showed excessive glycosylation was attached to pituitary PrP, and protease-resistant PrP (PrPres) was also detected. In addition, PrP deposition was also identified histologically in the islets of Langerhans, skin, muscle and peripheral nerves. It was suggested that PrP is involved in human endocrine mechanism, and it was also shown that pituitary tissue of prion disease cases contains PrPres and may be a source of infection.
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