| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
It has long been reported that adult neural stem cells (NSCs) possess significant plasticity. Interestingly, the plasticity of NSCs is also observed in lower organisms such as invertebrates. We have elucidated the molecular basis of how quiescent neural stem cells are reactivated by using powerful Drosophila genetics. We found that an evolutionarily conserved metabolic enzyme, whose function is required for the lipid metabolism, is required for the proper reactivation of NSCs. We found that this cell death is induced by cholinergic neuron-dependent manner. In addition, the acetylcholine level was increased in the mutant animals. The inhibition of the degradation of acetylcholine also attenuated the reactivation of wild-type quiescent neural stem cells ex vivo.
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